ROLE OF COMPLEMENT RECEPTOR 2 IN SYSTEMIC LUPUS ERYTHEMATOSUS

补体受体 2 在系统性红斑狼疮中的作用

• 批准号: 7719482
• 负责人: SUSAN A. BOACKLE
• 金额: $ 0.17万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719482
• 关键词: Animal Model; Antibody-Producing Cells; Blood Cells; Complement 3d Receptors; Computer Retrieval of Information on Scientific Projects Database; Funding; Gene Proteins; Grant; Institution; Lupus; Persons; Proteins; Research; Research Personnel; Resources; Role; Sorting - Cell Movement; Source; Systemic Lupus Erythematosus; United States National Institutes of Health; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Complement receptor 2 is a protein on antibody-producing cells believed to be important in lupus. We have shown that the gene for this protein is abnormal in an animal model of lupus, providing strong proof that it causes lupus. This receptor is also present at lower levels on the blood cells of people with lupus. In this study, we want to determine whether this change in the receptor is related to how sick a person with lupus is. We will look at the amount of this receptor on the blood cells of people with lupus at 3 month intervals for one year to see if the amount goes down when their lupus is more active. We will also try to sort out why the levels go down since this may help us understand what causes lupus and find better treatments.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 补体受体 2 是产生抗体的细胞上的一种蛋白质，被认为在狼疮中很重要。 我们已经证明，这种蛋白质的基因在狼疮动物模型中是异常的，这为它导致狼疮提供了强有力的证据。 这种受体在狼疮患者的血细胞中也存在较低水平。 在这项研究中，我们想要确定受体的这种变化是否与狼疮患者的病情有关。 我们将在一年内每隔 3 个月检查狼疮患者血细胞上这种受体的数量，看看当他们的狼疮更加活跃时，该受体的数量是否会下降。 我们还将尝试找出其水平下降的原因，因为这可能有助于我们了解狼疮的病因并找到更好的治疗方法。