FUNCTIONAL ANALYSIS OF COMPLEMENT RECEPTOR 2 AS A LUPUS SUSCEPTIBILITY GENE

补体受体2作为狼疮易感基因的功能分析

• 批准号: 7719540
• 负责人: SUSAN A. BOACKLE
• 金额: $ 0.03万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719540
• 关键词: Affect; Animal Model; Antibody-Producing Cells; Blood; Complement 3d Receptors; Computer Retrieval of Information on Scientific Projects Database; Funding; Gene Proteins; Genes; Grant; Individual; Institution; Lupus; Numbers; Proteins; Research; Research Personnel; Resources; Source; Susceptibility Gene; Testing; Tonsil; United States National Institutes of Health; Variant; receptor; receptor function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Complement receptor 2 is a protein on antibody-producing cells believed to be important in lupus. We have shown that the gene for this protein is abnormal in an animal model of lupus, providing strong proof that it causes lupus. We have also shown that certain variations in the gene for this protein are found more often in individuals who have lupus. In this study, we want to determine how the variations in the complement receptor 2 gene affect its function so that we can understand better how it might be involved in lupus. To do this, we will draw blood from different people who express different versions of the gene to test the function of the receptor in a number of different ways. In addition, we will obtain a small piece of the tonsils from some people to test the function of a form of the receptor that is expressed in the tonsils but not in the blood.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 补体受体 2 是产生抗体的细胞上的一种蛋白质，被认为在狼疮中很重要。 我们已经证明，这种蛋白质的基因在狼疮动物模型中是异常的，这为它导致狼疮提供了强有力的证据。 我们还表明，这种蛋白质基因的某些变异在狼疮患者中更常见。 在这项研究中，我们想要确定补体受体 2 基因的变异如何影响其功能，以便我们更好地了解它如何与狼疮有关。 为此，我们将从表达不同版本基因的不同人身上抽取血液，以多种不同的方式测试受体的功能。 此外，我们将从一些人身上获取一小块扁桃体，以测试在扁桃体中表达但在血液中不表达的受体形式的功能。