ROLE OF PPARA IN THE PREVENTION OF VASCULAR AGING BY HABITUAL EXERCISE

PPARA 在通过习惯锻炼预防血管老化中的作用

• 批准号: 7719561
• 负责人: DOUGLAS R SEALS
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719561
• 关键词: Affect; Aging; Blood Pressure; Blood Vessels; Blood flow; Cells; Computer Retrieval of Information on Scientific Projects Database; Elderly; Exercise; Fenofibrate; Functional disorder; Funding; Gene Expression; Grant; Heart Diseases; Inflammation; Institution; Oxidative Stress; PPAR alpha; Pharmaceutical Preparations; Prevention; Research; Research Personnel; Resources; Risk Factors; Role; Source; Stimulus; United States National Institutes of Health; age related; improved; prevent; receptor; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aging is a major risk factor for heart disease. Blood vessels should dilate or constrict in response to different stimuli, such as increased blood flow, to prevent drastic changes in blood pressure. When the blood vessels do not function properly this is usually the result of endothelial dysfunction. Increases in oxidative stress and inflammation are seen in aging and endothelial dysfunction. One way to lessen the age-related dysfunction is to exercise regularly. This study is looking at the role of peroxisome proliferator activated receptor alpha (PPARa) in dysfunction resulting from aging and physical inactivity. PPARa is a receptor in cells that affects expression of genes involved in oxidative stress and inflammation. We will increase PPARa activity with the drug fenofibrate. We expect that in older adults this increase in PPARa will improve endothelial function. The improvements in endothelial function will be related to reduced oxidative stress and inflammation. We also expect people who exercise regularly will have increased PPARa activity at baseline, and therefore their function will not be increased with fenofibrate.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 衰老是心脏病的主要危险因素。血管应响应不同的刺激（例如增加的血液流动）来扩张或收缩，以防止血压的急剧变化。 当血管无法正常工作时，这通常是内皮功能障碍的结果。在衰老和内皮功能障碍中可见氧化应激和炎症的增加。减少与年龄相关的功能障碍的一种方法是定期运动。这项研究正在研究过氧化物酶体增殖物激活受体α（PPARA）在衰老和身体不活跃引起的功能障碍中的作用。 PPARA是细胞中影响氧化应激和炎症基因表达的受体。我们将使用药物拟元型来增加PPARA活性。我们预计，在老年人中，PPARA的增加将改善内皮功能。内皮功能的改善将与减少氧化应激和炎症有关。我们还预计，定期运动的人会在基线时增加PPARA活动，因此，通过非诺贝特，他们的功能不会增加。