Characterization of endovascular ablative therapies with computational modeling

通过计算模型表征血管内消融治疗

基本信息

批准号：
10629321
负责人：
David Fuentes
金额：
$ 18.56万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-26 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10629321
关键词：
Ablation Acids Acute Aliquot Area Behavior Biochemistry Biological Blood flow Bolus Infusion Calibration Catheters Cell Death Characteristics Chemicals Chlorides Clinical Computer Models Convection Data Diameter Diffusion Disease Environment Equilibrium Goals Hydrochloric Acid Hydrolysis Hyperthermia Image Image Enhancement Inflammation Intervention Interventional radiology Intuition Investigation Ischemia Left Liver Mathematics Measurement Measures Methods Modality Modeling Monitor Neoplasm Metastasis Outcome Parents Patients Physics Porosity Primary carcinoma of the liver cells Procedures Process Property Protocols documentation Reaction Reagent Recurrence Reflexology Research Risk Route Solvents Techniques Temperature Therapeutic Embolization Thermal Ablation Therapy Thermal Conductivity Thermometry Tissues Translating Transport Process Validation Vascular blood supply Veterinary Pathology Viscosity chemical reaction clinical translation contrast enhanced curative treatments in vivo insight liver ablation liver function liver preservation mathematical model minimally invasive model development neoplastic cell novel novel strategies patient population porcine model preclinical study predictive modeling pressure prospective quantitative imaging risk minimization simulation tumor vascular bed virtual experiments

项目摘要

Curative therapies are not available to greater than 80% of the patient population with hepatocellular carcinoma (HCC). There is a well-recognized need for novel methods that can intricately balance (1) treatment of the disease extent with (2) preservation of liver function and minimizing risk of recurrence and metastasis. Thermoemboliza- tion provides a novel conceptual platform for minimally invasive interventions in which an acid chloride reagent is delivered through an endovascular route via transarterial catheter. The reagent is dissolved in an inert oily solvent and sandwiched between two aliquots of the inert solvent at the leading and trailing edges. Hydrolysis of the acid chloride within the target tissue simultaneously releases the parent acid and an equivalent of hy- drochloric acid. The localized release of acid combined with disruption of the blood supply as well as the heat energy from the exothermic reaction synergistically causes tumor cell death. Current challenges in translating this exciting therapy to patients are a lack of characterization of the mechanisms for a controlled delivery. Project efforts focus on integrating imaging measurements with mathematical model developments to provide key insight in developing this novel thermoembolization treatment approach. The use of high-ﬁdelity predictive models will characterize fundamental mass, thermal, and chemical transport processes needed for control of an effective thermoembolization delivery without unwanted tissue damage. A highly interdisciplinary team with expertise in imaging physics, mathematical modeling, interventional radiology, veterinary pathology, and biochemistry has been assembled to accomplish this goal.

超过 80% 的肝细胞癌患者无法获得治愈性治疗（HCC）。人们普遍认识到需要能够复杂地平衡（1）疾病治疗的新方法。 (2) 保留肝功能并最大限度地减少热栓塞的风险。化为微创干预提供了一个新颖的概念平台，其中酰氯试剂通过经动脉导管通过血管内途径输送。该试剂溶解在惰性油中。溶剂并夹在水解前缘和后缘的两份惰性溶剂之间。目标组织内的酰基氯同时释放母体酸和等量的氢盐酸的局部释放与血液供应和热量的破坏相结合。放热反应产生的能量协同导致肿瘤细胞死亡。这种对患者来说令人兴奋的疗法缺乏控制递送机制的表征。专注于将成像与数学工作相结合模型开发以提供测量关键见解在开发这种新型热栓塞治疗方法时，将使用高保真度预测模型。描述有效控制所需的基本质量、热和化学传输过程热栓塞治疗不会造成不必要的组织损伤，这是一个具有专业知识的高度跨学科团队。成像物理学、数学建模、介入放射学、兽医病理学和生物化学为实现这一目标而聚集。