Glomerular and Tubular Function in the Recovering Kidney

肾脏恢复中的肾小球和肾小管功能

• 批准号: 10587898
• 负责人: SCOTT Culver THOMSON
• 金额: $ 43.76万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10587898
• 关键词: Ablation; Acute; Acute Renal Failure with Renal Papillary Necrosis; Affect; Amino Acids; Angiotensins; Animals; Area; Behavior; Blood Pressure; Chronic Kidney Failure; Clinical; Clinical Trials; Compensation; Coupling; Creatinine clearance measurement; Data; Diagnosis; Diet; Disease; Electrolytes; Equilibrium; Event; Evolution; Excretory function; Feedback; Future; Glomerular Capillary; Glucose Transporter; Heterogeneity; Homeostasis; Hospitals; Human; Hypersensitivity; Hypoxia; Impairment; Incidence; Individual; Infarction; Infusion procedures; Injury; Injury to Kidney; Intervention; Ischemia; Kidney; Knowledge; Left; Liquid substance; Mathematics; Measures; Medical; Meta-Analysis; Metabolic stress; Metabolism; Methods; Micropuncture; Microscopic; Modeling; Nephrons; Outcome; Patients; Physiological; Physiology; Predisposition; Randomized; Rattus; Recovery; Regulation; Renal Blood Flow; Renal Mass; Renal function; Renin-Angiotensin System; Reperfusion Therapy; Research; Research Personnel; Saline; Sodium-Restricted Diet; Stress Tests; Techniques; Testing; Time; Tubular formation; Urine; absorption; base; design; dietary; experimental study; healing; hemodynamics; human model; human subject; improved; inhibitor; injured; preservation; pressure; prevent; response

Project Summary Abstract This research will provide information on the inner working of the kidney as it recovers from acute injury. Recovery of the kidney from acute injury is often incomplete and leaves behind a kidney that is prone to subsequent permanent decline due to physical and metabolic stresses of trying to compensate for incomplete healing. Ideally, targeted intervention would hasten recovery from acute kidney injury and diminish its long- term consequences. However, major knowledge gaps in the area of renal recovery currently preclude a rational approach to treatment. Knowledge gaps include the physical reason why the injured kidney appears to filter less fluid, the vulnerability of the injured kidney to be further injured by changes in blood pressure, or whether standard medical treatments or prescribed diets are helpful or harmful in patients recovering from kidney injury. Kidney features that are observed at the whole-kidney level emerge from events at the microscopic level and treatments have their direct effect at the microscopic level. However, there can be multiple combinations of microscopic events that could account for a given observation at the whole-kidney level. Therefore, microscopic behavior cannot be deduced from whole-kidney behavior and must be observed directly. This cannot be done in humans but can be done in rat models of human kidney injury using specialized techniques uniquely available to the investigators. Through these methods, this research will determine the effects of simple maneuvers on multiple internal variables thereby establishing boundary conditions for efficient design of future clinical trials in the field of kidney recovery.

项目概要 摘要 这项研究将提供有关肾脏从急性损伤恢复过程中内部运作的信息。 肾脏从急性损伤中恢复通常是不完全的，并且容易留下一个肾脏 由于试图补偿不完全的身体和代谢压力，随后出现永久衰退 康复。理想情况下，有针对性的干预将加速急性肾损伤的恢复并减少其长期影响。 术语后果。然而，目前肾脏恢复领域的主要知识差距阻碍了合理的研究。 治疗方法。知识差距包括受伤肾脏过滤能力似乎较差的物理原因 液体、受伤肾脏因血压变化而进一步受伤的脆弱性，或者是否 标准医疗或规定饮食对于肾损伤患者的康复有帮助或有害。 在整个肾脏水平观察到的肾脏特征源自微观水平的事件，并且 治疗在微观层面上有直接影响。然而，可以有多种组合 可以解释整个肾脏水平的特定观察结果的微观事件。因此，微观 行为不能从整个肾脏的行为中推断出来，必须直接观察。这不能在 人类，但可以使用独特的专门技术在人类肾损伤的大鼠模型中完成 给调查人员。通过这些方法，本研究将确定简单的操作对 多个内部变量，从而为未来临床试验的有效设计建立边界条件 在肾脏康复领域。