Training Program in Reproductive & Developmental Biology

生殖培训计划

• 批准号: 9079274
• 负责人: William Francis Crowley
• 金额: $ 12.22万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-15 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9079274
• 关键词: Developmental Biology; Reproductive Biology; Training Programs; Developmental Biology; Reproductive Biology; Training Programs

DESCRIPTION (provided by applicant): The long term goals of this T32 post-doctoral Training Program are twofold: 1). To recruit the best and brightest young physicians and basic science trainees interested in successful academic careers in biomedical research operating at the translational interface between bench and bedside using the contemporary tools of Reproduction, Development, and Genetics; and 2). To provide these high quality trainees with a secure period of stable funding so they can be exposed to: a) a rich spectrum of competitively funded and challenging biomedical problems; b) the most contemporary tools with which to attack them; c) optimal didactic experiences; and d) carefully mentored research experiences during periods of increasing autonomy. Taken together, this tight matrix of interwoven experiences equips our trainees with the foundational experiences necessary to achieve independence in research as is attested to by this program's track record of previous trainees. The key elements of success in meeting these goals are a rich pool of talented applicants and an exciting context within an Academic Medical Center. Our parent institution, the Massachusetts General Hospital (MGH), has a strong focus on human disease/disease models with a rich tradition of inter-disciplinary collaboration across a broad mix of talented training faculty (Tables 1 & 2). Each faculty member has been carefully selected by the Program Directors (PDs) on the basis of their demonstrated commitment to the independence of their trainees, exciting and important biologic problems on which to work, and stable funding. The spectrum of our program's planned research projects occurs in the laboratories of 11 mid- and senior level faculty members (Tables 1-4), each focused on key questions in human development, reproduction, systems and molecular biology, and/or genetics. Our Training Program taps into an exciting blend of basic and clinical researchers who have chosen to focus their interdisciplinary skills on human disease targets, i.e. the genetics of Mendelian development disorders like Isolated GnRH Deficiency, fetal congenital lung and diaphragmatic anomalies, neurologic disorders, as well as complex genetic disorders such as polycystic ovarian syndrome (PCOS). Given our nation's pressing need and expressed priorities for training translational researchers pointed out by the Institute of Medicine's Clinical Research Roundtable (References Cited: 1 & 2) as well as the powerful synergies emerging in reproduction, development and genetics, we propose to continue our current level of training 4 physicians and/or basic scientists for the next 5 years of this competing renewal application.

描述（由申请人提供）：该T32博士后培训计划的长期目标是双重：1）。使用当代的复制，发展和遗传学工具，招募了对在长凳和床边之间的转化界面上运作的生物医学研究中成功学术职业感兴趣的最佳和最聪明的年轻医生和基础科学学员；和2）。为了为这些高质量的学员提供稳定的稳定资金时期，因此可以接触到：a）丰富的竞争性资助和具有挑战性的生物医学问题； b）攻击它们的最现代工具； c）最佳的教学经验； d）在增加自主权期间，精心指导的研究经验。 综上所述，这种交织的经验的紧密矩阵使我们的学员拥有实现研究独立性所必需的基本经验，这是该计划对以前的受训者的往绩所证明的。 实现这些目标的成功的关键要素是一群才华横溢的申请人和学术医疗中心中令人兴奋的背景。我们的家长机构马萨诸塞州综合医院（MGH）强烈关注人类疾病/疾病模型，具有丰富的跨学科合作的传统，构成了广泛的才华横溢的培训学院（表1＆2）。计划董事（PDS）仔细选择了每个教职员工，因为他们表现出对学员独立的承诺，令人兴奋的重要生物学问题以及稳定的资金。 我们计划计划的研究项目的范围发生在11名中级和高级教职员工（表1-4）的实验室中，每个教师的范围都集中在人类发展，繁殖，系统和分子生物学和/或遗传学的关键问题上。我们的培训计划融入了基本和临床研究人员的激动人心的融合，他们选择将其跨学科技能集中在人类疾病目标上，即Mendelian发育障碍的遗传学，例如孤立的GNRH缺乏症，胎儿先天性肺肺和肿瘤异常，神经系统疾病，神经系统疾病，以及复杂的基因综合综合综合症）。 鉴于我们国家的迫切需求并表示了培训培训转化研究人员的优先级，并由医学研究所的临床研究圆桌会议（参考文献：1＆2）以及在复​​制，发展和遗传学方面出现的强大协同作用，我们建议继续我们目前的培训4次培训4年的物理学家和/或基础科学家，以实现这一竞争竞争的培训。