SEVEN DAYS OF EXOGENOUS PULSATILE GNRH, PITUITARY GONADAL AXIS/HYPOGONADOTROPIC

七天外源性脉动 GNRH、垂体性腺轴/促性腺激素低下

• 批准号: 7731228
• 负责人: William Francis Crowley
• 金额: $ 0.34万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731228
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Genetic; Goals; Gonadotropin Hormone Releasing Hormone; Grant; Hormonal Change; Individual; Institution; Kallmann Syndrome; Measures; Protocols documentation; Reproduction; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; day; hormone deficiency; human male; men; pituitary gonadal axis; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this protocol is to investigate the control of reproduction and to better understand the role of gonadotropin-releasing hormone (GnRH) in human male reproduction. In this study, men with GnRH deficiency (also known as Kallmann syndrome) are treated with pulsatile GnRH for 7 days and hormonal changes are measured. This provides information about an individual's response to GnRH and provides important information for our additional study looking into the genetic causes of this disease.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该方案的总体目标是研究繁殖的控制，并更好地了解促性腺激素释放激素（GNRH）在人类男性繁殖中的作用。 在这项研究中，用脉冲GNRH处理具有GNRH缺乏症的男性（也称为Kallmann综合征）7天，并测量激素变化。 这提供了有关个人对GNRH反应的信息，并为我们的额外研究提供了重要的信息，以了解这种疾病的遗传原因。