COMBINED PHARMACO/BEHAVIOR THERAPY IN ADOLESCENT SMOKERS

青少年吸烟者的药物/行为联合治疗

• 批准号: 7719575
• 负责人: KATHLEEN T. BRADY
• 金额: $ 2.79万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719575
• 关键词: Adolescent; Adult; Age; American; Area; Behavior Therapy; Bupropion; Cause of Death; Cigarette Smoker; Combination Medication; Computer Retrieval of Information on Scientific Projects Database; Daily; Funding; Grant; Health; Illicit Drugs; Individual; Institution; Morbidity - disease rate; Nicotine; Outcome; Pharmaceutical Preparations; Public Health; Rate; Research; Research Personnel; Resources; Smoke; Smoker; Smoking; Social Welfare; Source; Testing; Tobacco; United States; United States National Institutes of Health; cigarette smoking; contingency management; day; high school; improved; mortality; smoking cessation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cigarette smoking is the most common form of nicotine use, causes significant morbidity and mortality and has been described as the single most preventable cause of death in the United States (US Department of Health and Welfare, 1979; 1990). Even though rates of smoking have declined among adolescents recently, it is an area of considerable public health concern since about 17% of high-school seniors smoke daily (Johnston et al., 2002). It has been estimated that 3,000 adolescents start to smoke every day. Tobacco is often one of the first drugs tried by individuals who later use illicit drugs (Kandel et al., 1978; Kandel and Yamaguchi, 1993), and 80% of adult smokers become addicted to tobacco by age 18 (American Health Association, 1995). In the current proposal, we intend to study the efficacy of bupropion SR with or without combined contingency management (CM) among adolescent cigarette smokers. The proposed study will test not only medication (bupropion SR), but also combination of medication and CM in potentially improving smoking cessation outcomes AND retention of adolescent smokers in the study.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 吸烟是尼古丁使用的最常见形式，引起了大量的发病率和死亡率，并被描述为美国唯一可预防的死亡原因（美国卫生与福利部，1979年； 1990年）。 尽管最近青少年的吸烟率下降了，但由于大约17％的高中生每天吸烟，这是一个相当大的公共卫生问题的领域（Johnston等，2002）。 据估计，每天有3,000名青少年开始吸烟。 烟草通常是后来使用非法药物的个体尝试的最早的药物之一（Kandel等，1978; Kandel and Yamaguchi，1993），而80％的成年吸烟者到18岁时就会上瘾（美国健康协会，1995年）。 在当前的提案中，我们打算研究青少年吸烟者中有或没有合并应急管理（CM）的安非他酮SR的功效。 拟议的研究不仅将测试药物（安非他酮SR），还将在研究中可能改善吸烟结果和保留青春期吸烟者的保留率，在研究中的药物和CM结合。