METHYLPHENIDATE-ETHANOL INTERACTIONS IN ADHD AND CO-ABUSE

哌醋甲酯-乙醇在多动症和共同滥用中的相互作用

• 批准号: 7719605
• 负责人: KENNERLY Sexton PATRICK
• 金额: $ 0.08万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719605
• 关键词: Alcohol consumption; Alcohols; Attention deficit hyperactivity disorder; Blood Circulation; Computer Retrieval of Information on Scientific Projects Database; Ethanol; Funding; Grant; Human; Institution; Isomerism; Marketing; Medical; Methylphenidate; Pharmaceutical Preparations; Purpose; Research; Research Personnel; Resources; Ritalin; Schedule; Source; United States National Institutes of Health; Woman; dexmethylphenidate; drinking; ethylphenidate; men; prescription document; prescription procedure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to determine if there are differences in the amount of Ritalin or Focalin absorbed depending on whether alcohol is also administered. Recently, an MUSC study has found that when the prescription Attention Deficit/Hyperactivity Disorder (ADHD) medication Ritalin (generically called dl-methylphenidate) is combined with a drink containing ethyl alcohol (drinking alcohol), the alcohol increases the amount of Ritalin absorbed from the gut into the bloodstream. Also, humans were found to form a Ritalin -alcohol product called ethylphenidate. The Drug Enforcement Administration classifies both Ritalin , and the pure d-isomer form of methylphenidate marketed as Focalin (generically called dexmethylphenidate), as Schedule II drugs. This means that these drugs have a high abuse potential while still being recognized as possessing beneficial medical uses, e.g., to treat ADHD. Further, the extent of ethylphenidate formation will be established, as well as potential differences between men and women.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是确定基于是否也给予酒精的利他蛋白素或焦点蛋白吸收的量是否存在差异。最近，一项MUSC研究发现，当处方注意力不足/多动障碍（ADHD）药物利他蛋白（通常称为DL-甲基苯甲酸酯）与含有乙醇酒精（饮酒饮酒）的饮料相结合时，酒精会增加从肠道吸收的利他蛋白素的量。同样，发现人类形成一种称为乙甲甲酯的利他蛋白 - 酒精产物。药物执法局将利他蛋白归类为二甲甲化物的纯d-异构体形式，称为focalin（通常称为右甲基苯甲酯），为附表II药物。这意味着这些药物具有很高的滥用潜力，同时仍被认为具有有益的医疗用途，例如治疗多动症。 此外，将建立乙二甲酯形成的程度，以及男性和女性之间的潜在差异。