INNATE IMMUNE SYSTEM IN SIV INFECTION

SIV 感染中的先天免疫系统

• 批准号: 7716164
• 负责人: Luis David Giavedoni
• 金额: $ 0.29万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716164
• 关键词: Affect; Animal Model; Anti-Inflammatory Agents; Anti-inflammatory; Cells; Cellular Immunity; Chronic; Computer Retrieval of Information on Scientific Projects Database; Containment; Cytokine Signaling; Disease; Disease Progression; Event; Funding; Grant; HIV Infections; Human; Immune; Immune system; Immunity; Individual; Infection; Institution; Macaca mulatta; Mediating; Outcome; Patients; Production; Research; Research Personnel; Resources; Role; SIV; Source; Time; United States National Institutes of Health; Upper arm; Vaccines; Viral; Virus; cytokine; pathogen

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although cell-mediated immunity is associated with viral control in HIV-infected humans and in the SIV/rhesus macaque animal model, we still do not exactly know what allows some HIV-exposed individuals to resist infection, HIV-infected patients to remain disease free for several years, or the type of immunity needed for vaccine-mediated protection against disease. The outcome of a pathogen-host interaction seems to depend mainly on events that occur at times of the initial contact, and signals and cytokines produced by the innate immune system affect the actions of the adaptive immune system. Our hypothesis is that both arms of the immune system participate in the initial containment of viral replication and in vaccine protection. We will demonstrate the role of the innate and adaptive immune systems during chronic infection with SIV in rhesus macaques. These studies will determine if changes in immune cells, or production of virus-specific anti-inflammatory cytokines are associated with disease progression during chronic infection.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 尽管细胞介导的免疫与HIV感染的人类和SIV/恒河猴动物模型中的病毒控制有关，但我们仍然不完全知道是什么允许某些艾滋病毒暴露的人抵抗感染，HIV感染的患者可以免于疾病，或者是疫苗介导的免疫类型，用于疫苗介导的疾病的免疫类型。病原体宿主相互作用的结果似乎主要取决于最初接触时发生的事件，而先天免疫系统产生的信号和细胞因子会影响适应性免疫系统的作用。我们的假设是，免疫系统的两个臂都参与了病毒复制和疫苗保护的最初遏制。我们将证明在恒河猕猴中使用SIV慢性感染中先天和适应性免疫系统的作用。这些研究将确定免疫细胞的变化或病毒特异性抗炎细胞因子的产生是否与慢性感染过程中的疾病进展有关。