Metabolic/gas exchange system

代谢/气体交换系统

• 批准号: 10629673
• 负责人: KENNETH K KWONG
• 金额: $ 16.12万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10629673
• 关键词: Area; Boston; Brain; Cardiovascular system; Clinical; Clinical Research; Devices; Diagnostic Imaging Program; Ensure; Equipment; Funding; Future; Gases; Image; Institution; Long COVID; Lung; Magnetic Resonance Imaging; Magnetoencephalography; Metabolic; Monitor; Physiological; Positron-Emission Tomography; Rehabilitation therapy; Request for Applications; Research; Research Subjects; Safety; System; biomedical imaging; imaging modality; imaging platform; optical imaging; pandemic disease; pulmonary function; research and development; software development; success; tool

PROJECT SUMMARY This application requests funding to purchase a Metabolic/Gas Exchange system. The state-of- the-art Metabolic Gas Exchange system is the only system with accessories made compatible with magnetic resonance imaging (MRI) to acquire a wide range of breath-by-breath gas exchange and pulmonary function parameters. In addition, a set of comprehensive vital monitoring tools will be equipped to ensure the safety of the research subjects and the needs of physiological recordings in different clinical and hardware/software development research at the Martinos Center, across different departments at MGH, as well as different institutions in the Boston area. The proposed Metabolic/Gas Exchange system is especially important to ensure the continuity of the existing funded projects and the synergistic research in the future. The system not only serves as a replacement of the existing equipment constructed with separate pieces of outdated devices that are nearly worn out but also provides a wider opportunity for synergizing research in the study of brain activity in association with pulmonary function and gas exchange. For example, one major area in the near future is mechanistic and clinical research for the potential upcoming rehabilitation pandemic of long COVID, which involves studying the interaction between the brain, pulmonary system, and cardiovascular system. The proposed Metabolic/Gas Exchange system will be located within the Athinoula A. Martinos Center for Biomedical Imaging, MGH. The Martinos Center has a renowned biomedical imaging program, consistently producing successes with imaging modalities such as MRI, magnetoencephalography (MEG), positron emission tomography (PET), and optical imaging. The proposed system will be fully utilized in the existing and future imaging research on this successful imaging platform for the users at Martinos Center and the other institutions in Boston.

项目概要 该申请需要资金来购买代谢/气体交换系统。现状—— 最先进的代谢气体交换系统是唯一具有兼容的配件的系统 磁共振成像（MRI）可获取广泛的每次呼吸气体交换和 肺功能参数。此外，还将提供一套全面的生命监测工具。 配备确保研究对象的安全和生理记录的需要 马蒂诺斯中心的不同临床和硬件/软件开发研究，跨越不同领域 MGH 部门以及波士顿地区的不同机构。 拟议的代谢/气体交换系统对于确保代谢/气体交换的连续性尤其重要 现有资助项目及未来协同研究。该系统不仅可以作为 更换由单独的过时设备构成的现有设备 几乎已经耗尽，但也为大脑研究的协同研究提供了更广泛的机会 与肺功能和气体交换相关的活动。例如，一个主要区域 不久的将来是针对即将到来的康复大流行的机制和临床研究 长期新冠肺炎的研究，涉及研究大脑、肺系统和 心血管系统。 拟议的代谢/气体交换系统将位于 Athinoula A. Martinos 内 麻省总医院生物医学成像中心。马蒂诺斯中心拥有著名的生物医学成像 计划，通过 MRI 等成像方式不断取得成功， 脑磁图 (MEG)、正电子发射断层扫描 (PET) 和光学成像。这 所提出的系统将在现有和未来的成像研究中得到充分利用 为马蒂诺斯中心和波士顿其他机构的用户提供成像平台。