Next-generation 3 Tesla Human MRI System

下一代 3 特斯拉人体 MRI 系统

• 批准号: 10630654
• 负责人: Susie Yi Huang
• 金额: $ 200万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630654
• 关键词: 16 year old; Acceleration; Area; Basic Science; Boston; Brain; Brain Mapping; Brain imaging; Childhood; Clinical; Clinical Research; Cognitive; Collaborations; Communities; Complement; Computer software; Computers; Custom; Development; Fostering; Funding; Grant; Heart; Hospitals; Human; Human body; Image; Imaging Techniques; Institution; Magnetic Resonance Imaging; Modernization; Neurosciences; Performance; Physiologic Monitoring; Physiologic pulse; Productivity; Prostate; Research; Research Personnel; Research Support; Resolution; Resources; Site; Standardization; Structure; Structure-Activity Relationship; System; Technology; Tissues; Translational Research; United States National Institutes of Health; Vendor; biomedical imaging; body system; cancer imaging; cardiovascular imaging; data quality; density; fetal; frontier; image reconstruction; improved; innovation; instrumentation; neuroimaging; next generation; novel; pressure; programs; system architecture; technology development; tractography; whole body imaging

PROJECT ABSTRACT This grant will support the purchase of a new Siemens 3 Tesla whole-body human MRI scanner to be used for basic, clinical and translational research at the Athinoula A. Martinos Center for Biomedical Imaging, serving investigators at Mass General Brigham and other Boston area hospitals and academic institutions. The next- generation 3T whole-body system will serve as an upgrade of our existing, 16-year-old obsolete 3 Tesla MRI scanner that is reaching imminent end-of-support status by the vendor and has seen diminishing usage over the last 5 years. The proposed next-generation 3T system with high performance gradients will enable very high gradient strengths and slew rates (up to 200 mT/m and 200 T/m/s on each axis) for whole-body imaging. It will offer a substantial increase of performance for the wide range of research performed at Mass General Brigham and the greater Boston area, justified on a shared-use basis by over 25 investigators and 30 projects, the vast majority of which are NIH-funded. The breadth of supported research spans clinical and translational neuroimaging, cardiovascular, body, and oncologic imaging; fetal and pediatric brain imaging; cognitive, psychiatric, and basic neuroscience and brain mapping studies; and novel instrumentation development. While the 3 Tesla MRI research program at the Martinos Center has been very successful, the system to be replaced uses outdated hardware and software, placing substantial pressure on our other 3 Tesla systems, which cannot accommodate the advanced technological needs of our expanding user community. Because of the unique capabilities of the new state-of-the-art 3T whole-body MRI, the proposed Next Generation 3 Tesla Human MRI upgrade will offer new features for improved performance and data quality that will benefit existing projects and complement the other scanners at the Martinos Center. This upgrade features: higher performance gradients for high spatial resolution tractography and delineation of tissue microstructure in the brain, heart and prostate; enhanced RF system architecture with 128 receive channels and higher density specialized coils; streamlined workflows for greater ease of use; standardized hardware and software for compatibility with other sites; a faster image reconstruction computer enabling modern imaging techniques; integrated physiological monitoring; new sequence and application packages for accelerated, multi-contrast exams; and an up-to-date testbed for the unique instrumentation and technology development performed at the Martinos Center, including the latest software platform for pulse sequence programming and custom on-scanner image reconstruction. By serving a highly productive interdisciplinary group of NIH-funded investigators, the proposed upgrade will offer a cutting- edge research resource that will push the frontiers of investigating structure-function relationships at finer scales and higher sensitivity, thereby enhancing existing research programs and fostering opportunities for new projects and collaborations. This instrumentation upgrade will provide our investigators with the technological edge required for innovative clinical, translational, and basic research.

项目摘要 这笔赠款将支持购买一台新的西门子 3 Tesla 全身人体 MRI 扫描仪，用于 Athinoula A. Martinos 生物医学成像中心的基础、临床和转化研究，服务于 麻省总医院和波士顿地区其他医院和学术机构的研究人员。接下来—— 第 3 代全身系统将作为我们现有的、已有 16 年历史的 3 Tesla MRI 的升级版 扫描仪即将达到供应商的支持终止状态，并且使用量正在减少 过去 5 年。拟议的具有高性能梯度的下一代 3T 系统将实现非常高的 用于全身成像的梯度强度和转换速率（每个轴上高达 200 mT/m 和 200 T/m/s）。它将 为麻省布里格姆总医院进行的广泛研究提供了显着的性能提升 和大波士顿地区，超过 25 名研究人员和 30 个项目在共享使用的基础上证明了这一点， 其中大部分是 NIH 资助的。支持研究的广度涵盖临床和转化 神经影像、心血管、身体和肿瘤成像；胎儿和儿童脑成像；认知的， 精神病学、基础神经科学和脑图研究；以及新型仪器仪表的开发。尽管 马蒂诺斯中心的 3 特斯拉 MRI 研究计划非常成功，系统即将更换 使用过时的硬件和软件，给我们的其他 3 个 Tesla 系统带来了巨大的压力，这些系统无法 满足我们不断扩大的用户群体的先进技术需求。因为独特 新的最先进的 3T 全身 MRI 的功能，即拟议的下一代 3 Tesla 人体 MRI 升级将提供改进性能和数据质量的新功能，这将有利于现有项目和 与马蒂诺斯中心的其他扫描仪相补充。此次升级的特点是：更高的性能梯度 高空间分辨率纤维束成像和大脑、心脏和前列腺组织微观结构的描绘； 增强型射频系统架构，具有 128 个接收通道和更高密度的专用线圈；精简的 工作流程更加易于使用；标准化硬件和软件以与其他站点兼容；更快的 支持现代成像技术的图像重建计算机；综合生理监测；新的 用于加速、多重对比检查的序列和应用程序包；以及最新的测试平台 马蒂诺斯中心进行了独特的仪器和技术开发，包括最新的 用于脉冲序列编程和定制扫描仪图像重建的软件平台。通过服务 由 NIH 资助的研究人员组成的高产跨学科小组，拟议的升级将提供尖端的 边缘研究资源，将推动更精细尺度上结构-功能关系研究的前沿 和更高的敏感性，从而加强现有的研究计划并为新项目创造机会 和合作。此次仪器升级将为我们的研究人员提供技术优势 创新临床、转化和基础研究所需。