VALIDATION OF MRI IMAGES OF THE TONGUE TO STUDY DYSTHAGIA

验证舌头 MRI 图像以研究吞咽困难

• 批准号: 7716472
• 负责人: JOANNE ROBBINS
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716472
• 关键词: Adult; Anatomy; Animals; Anterior; Area; Brain imaging; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Deglutition; Deglutition Disorders; Electronics; Functional Magnetic Resonance Imaging; Funding; Grant; Hand; Human; Image; Imaging Techniques; Institution; Magnetic Resonance Imaging; Methods; Modeling; Monkeys; Motor; Muscle; Numbers; Participant; Primates; Research; Research Design; Research Personnel; Resources; Review, Systematic (PT); Sensory; Services; Source; Tongue; United States National Institutes of Health; Validation; Work; cingulate cortex; improved; neurophysiology; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To study swallowing in humans, using a nonhuman primate model, to improve treatments of dysthagia (swallowing problems). About 18 million adults and many more millions of children have swallowing problems in the U.S. This may be due to changes in the tongue, weaker muscles and fewer muscles, so we are using a nonhuman primate model to more closely study primate anatomy to explore new avenues to treating dysthagia. We are validating the MRI work we are doing in humans and monkeys. Unknowns about the neurophysiology of normal and disordered swallowing have stimulated exciting and important research questions. Previously, these questions were answered using clinical and animal studies. However, recent technologic advances have moved brain-imaging techniques such as functional magnetic resonance imaging (fMRI) to the forefront of swallowing neurophysiology research. This systematic review has summarized the methods and results of studies of swallowing neurophysiology of healthy adults using fMRI. A comprehensive electronic and hand search for original research was conducted, including few search limitations to yield the maximum possible number of relevant studies. The participants, study design, tasks, and brain image acquisition were reviewed and the results indicate that the primary motor and sensory areas were most consistently active in the healthy adult participants across the relevant studies. Other prevalent areas of activation included the anterior cingulate cortex and insular cortex. This research uses WNPRC Animal Services.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 使用非人类灵长类动物模型研究人类的吞咽，以改善心脏治疗方法（吞咽问题）。 在美国，约有1800万成年人和数百万儿童吞咽问题，这可能是由于舌头变化，肌肉较弱和肌肉较少的原因，因此我们使用非人类的灵长类动物模型来更仔细地研究灵长类动物解剖结构，以探索治疗心痛的新途径。我们正在验证我们在人类和猴子所做的MRI工作。 关于正常和无序吞咽的神经生理学的未知数刺激了令人兴奋而重要的研究问题。以前，使用临床和动物研究回答了这些问题。然而，最近的技术进步已将诸如功能磁共振成像（fMRI）之类的脑成像技术转移到吞咽神经生理学研究的最前沿。这项系统评价总结了使用fMRI的健康成年人吞咽神经生理学的方法和结果。进行了全面的电子和手工搜索原始研究，其中包括很少有搜索限制，以产生最大可能的相关研究数量。审查了参与者，研究设计，任务和大脑图像的获取，结果表明，在相关研究的健康成人参与者中，主要运动和感觉领域最始终如一。其他普遍的激活区域包括前扣带回皮层和岛状皮质。 该研究使用WNPRC动物服务。