Behavior Core

行为核心

基本信息

批准号：
10631137
负责人：
TAMARA E KING
金额：
$ 26.62万
依托单位：
UNIVERSITY OF NEW ENGLAND
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10631137
关键词：
Academia Affective Animal Experimentation Anxiety Area Behavior Behavioral Behavioral Assay Biological Biomedical Research Breeding Businesses Caliber Centers of Research Excellence Client Cognitive Communities Consultations Contracts Core Facility Cost Sharing Data Analyses Dedications Department chair Development Educational workshop Endowment Ensure Equipment Experimental Designs Extramural Activities Faculty Fee-for-Service Plans Feedback Fees Fostering Foundations Funding Genotype Goals Grant Growth Human Resources Impaired cognition Income Industry Institution Investments Island Laboratories Letters Maine Maintenance Marketing Measures Medical Research Mental Depression Modeling Mus Neurons New England Operative Surgical Procedures Osteopathic Medicine Pain Phase Procedures Protocols documentation Publications Rattus Reproducibility Research Research Institute Research Personnel Research Support Resources Rodent Sensory Services Standardization Strategic Planning Stream Structure Students Technical Expertise Techniques Technology Testing Time Training Transgenic Mice United States National Institutes of Health Universities Validation Work addiction austin base behavior test behavioral study chronic pain cohort college comorbidity cost drug development drug discovery equipment acquisition experimental study faculty support field study in vivo evaluation industry partner innovation instrumentation model development mouse model neural circuit nociceptive response optogenetics pain model pharmacologic pre-clinical programs sustainable resource tool training opportunity voucher

项目摘要

The Behavior Core is built on a strong foundation of expertise in the fields of rodent sensory testing, pharmacological and optogenetic manipulation of neurons, preclinical early-stage drug discovery and development, and genotyping and colony management. The BC has become a critical resource for both COBRE and non-COBRE-affiliated investigators at the University of New England (UNE), regional and national academic users, and industry partners. Across Phase 3, the Core will continue to build on this diverse user base to create a stable and reliable revenue stream with the goal of becoming a sustainable resource for users requiring high quality in vivo testing. The BC will continue to provide (a) a centralized space for many behavioral assays and surgical procedures; (b) standardized protocols and training between laboratories to reduce variability and increase reproducibility and validity of behavioral assays; (c) advanced training and model development and validation (e.g., alternatives to reflexive nociceptive responses such as affective, cognitive, and pain- suppressed readouts). New developments include expanded space and equipment for independent testing areas for rats and mice to increase throughput and diminish potential confounds of testing both species in the same areas, expanded breeding and genotyping services to support the increased utilization of genetically-modified mouse and rat models, and support for investigators’ utilization of optogenetic approaches in behavioral studies. Continued training of Core research staff will be provided to ensure that the highest level of innovation and support can be provided to Behavior Core users. User feedback from internal and external users has consistently been highly positive. Core personnel have been included as authors on publications and Behavior Core services have been included in NIH grant submissions. Continued investments in its capabilities will allow the Core to provide the latest experimental tools in animal research and help the Core transition to fiscal independence. Noting the value that the COBRE research cores bring to UNE, the institution has outlined a commitment to support the Behavior Core for at least 5 years beyond the end of the Phase 3 funding period. Institutional commitments include dedicated laboratory space and shared costs for equipment purchase, maintenance, and upgrades, a voucher program for Behavior Core use and training, and support of dedicated effort for Core Directors. Such support will foster the growth and expansion of Behavior Core resources required to maintain the high-quality services currently appreciated by current users. The Behavior Core Director has worked closely with neighboring COBRE and INBRE supported research cores at the Maine Medical Research Institute and the Mount Desert Island Biological Laboratory to coordinate Behavior Core services with other regional research cores. This coordination will allow the Behavior Core to broaden its user base as it prepares for long-term sustainability.

行为核心建立在啮齿动物感官测试、药理学和神经元的光遗传学操作、临床前早期药物发现和开发以及基因分型和克隆 BC 已成为 COBRE 和非 COBRE 附属调查人员的重要资源。新英格兰大学 (UNE)、区域和国家学术用户以及跨阶段 3 的行业合作伙伴。将继续以多元化的用户群为基础，创造稳定可靠的收入来源，目标是成为 BC 将继续为需要高质量体内测试的用户提供可持续资源。许多行为测定和外科手术的空间；(b) 实验室之间的标准化协议和培训 (c) 高级培训和模型，减少变异性并提高行为分析的可重复性和有效性；开发和验证（例如，反射性伤害性反应的替代方案，如情感、认知和疼痛）新的发展包括扩大大鼠和独立测试区域的空间和设备。小鼠以提高吞吐量并减少在同一区域测试两个物种的潜在混淆，扩大育种和基因分型服务，以支持增加转基因小鼠和大鼠模型的利用，以及支持研究人员在行为研究中利用光遗传学方法。继续培训核心研究。将配备工作人员，以确保为行为核心用户提供最高水平的创新和支持。内部和外部用户的用户反馈一直非常积极，核心人员也已包括在内。作为出版物和行为核心服务的作者已包含在 NIH 拨款申请中（继续）。对其能力的投资将使核心能够提供动物研究的最新实验工具，并帮助注意到 COBRE 研究核心给 UNE 带来的价值，该机构已经实现了向财政独立的核心过渡。概述了在第三阶段资助期结束后至少 5 年支持行为核心的承诺。机构承诺包括专用实验室空间和分担设备采购、维护和使用的成本升级、行为核心使用和培训的代金券计划以及对核心董事的专注努力的支持。支持将促进维持高质量服务所需的行为核心资源的增长和扩展目前，行为核心总监与邻近的 COBRE 和 COBRE 密切合作，受到当前用户的赞赏。 INBRE 支持缅因州医学研究所和山漠岛生物研究所的研究核心实验室与其他区域研究核心协调行为核心服务。 Behaviour Core 旨在扩大用户群，为长期可持续发展做好准备。