AREA I BIOMOLECULAR STRUCTURE & FUNCTION: AIDS

I 区生物分子结构

• 批准号: 7959166
• 负责人: DAVID CALHOUN
• 金额: $ 72.27万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959166
• 关键词: Acquired Immunodeficiency Syndrome; Area; Biochemistry; Bioinformatics; Biological Process; Biotechnology; Complement; Computer Retrieval of Information on Scientific Projects Database; Computer-Assisted Image Processing; Development; Electron Microscopy; Equipment; Event; Faculty; Funding; Genetic Transcription; Goals; Grant; Institution; Molecular; New York City; Pathway interactions; Recruitment Activity; Research; Research Personnel; Resources; Roentgen Rays; Secure; Source; Structure; Techniques; United States National Institutes of Health; Work; X ray diffraction analysis; X-Ray Diffraction; base; college; macromolecular assembly; macromolecule; member; molecular assembly/self assembly; new technology; protein folding; protein structure; research and development; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major Area I goals are to elucidate the structures and functions of biological molecules with the aim of understanding and explaining their functions in development and in cellular events. A major new initiative for the five-year renewal is to recruit a new faculty member in the area of X-ray diffraction for the determination of protein structure and to provide startup funds to equip this facility. Our request for the hire of an X-ray crystallographer is motivated by the need to complement and enhance the ongoing structural work carried out by NMR. We have also secured X-ray crystalography equipment which was donated by Novartis and set up through funds from the college in the new Pathways Bioinformatics and Biotechnology Center at CCNY. Recent developments in biochemistry and structural biology allow members of Area I to further expand their areas of study into large macromolecules and macromolecular assemblies. To be more productive and competitive, they must exploit the new technologies and turn to increased use of NMR techniques in conjunction with the NMR facilities that are integral to the New York City Structural Biology Center. In accord with this goal we have added Dr. Sacha De Carlo whose research focuses on 3D electron microscopy and computer-assisted image processing to study the structure, function and dynamics of molecular assemblies involved in fundamental biological processes such as protein folding and transcription.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 第一领域的主要目标是阐明生物的结构和功能 分子的目的是理解和解释它们在发育中的功能 以及细胞事件中。 五年更新的一项重大新举措是招募新的 用于确定蛋白质结构的 X 射线衍射领域的教员 并提供启动资金来装备该设施。 我们要求租用 X 光检查 晶体学家的动机是需要补充和增强正在进行的 通过NMR进行结构工作。 我们还获得了 X 射线晶体学 设备由诺华公司捐赠并由学院资助建立 CCNY 的新 Pathways 生物信息学和生物技术中心。 生物化学和结构生物学的最新发展使 I 区成员能够 进一步将研究领域扩展到大分子和大分子 组件。 为了提高生产力和竞争力，他们必须利用新的 技术，并转向增加将 NMR 技术与 NMR 结合使用 纽约市结构生物学中心不可或缺的设施。 按照这个目标 我们添加了 Sacha De Carlo 博士，他的研究重点是 3D 电子显微镜和计算机辅助 图像处理以研究相关分子组装体的结构、功能和动力学 蛋白质折叠和转录等基本生物过程。