Mechanisms of Improved Endothelial Function with Regular Exerecise in Older Adult

老年人定期运动改善内皮功能的机制

基本信息

批准号：
7626368
负责人：
Anthony John Donato
金额：
$ 12.25万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-15 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7626368
关键词：
Acetylcholine Acute Acute-Phase Proteins Aerobic Exercise Aging Antioxidants Ascorbic Acid Attention Biological Availability Blood Vessels Blood flow Cardiovascular system Cells Colorado Disodium Salt Nitroprusside Doctor of Philosophy Elderly Endothelium Enzyme Gene Enzymes Exercise Forearm Genes Health Human Inflammation Inflammatory Infusion procedures Intervention Life Measurement Measures Mediating Messenger RNA Molecular Mononuclear Nitrates Nitric Oxide Nitrites Nuclear Oxidants Oxidative Stress Peripheral Physiological Physiology Plasma Production Reactive Oxygen Species Research Research Project Grants Role Superoxide Dismutase System Universities Vascular Endothelial Cell Vascular Endothelium Woman Work artery infusion brachial artery cytokine disorder risk extracellular human NOS3 protein improved inhibitor/antagonist middle age older men omega-N-Methylarginine primary outcome protein expression response secondary outcome sedentary transcription factor urinary

项目摘要

DESCRIPTION (provided by applicant): The candidate, Anthony J. Donate Ph.D., is a cardiovascular physiologist in the Department of Integrative Physiology at the University of Colorado at Boulder. Dr. Donato's research focuses on the mechanisms mediating vascular aging in humans and how habitual aerobic exercise can preserve and restore vascular health with aging. The aim of the research project is to establish the efficacy of a 12-week aerobic exercise intervention for restoring vascular endothelial function in middle-aged and older men and women by inducing reductions in oxidative stress and increases in nitric oxide bioavailability. The proposed research will use an "integrative" (system to gene) approach to identify the cellular and molecular mechanisms by which habitual exercise restores endothelial function in this group, including measurements of vascular endothelial expression of proteins influencing oxidative stress, inflammation and nitric oxide production. The expected results should provide clinically important information regarding the integrative physiological mechanisms by which habitual aerobic exercise improves vascular endothelial function in middle-aged and older adults.

描述（由申请人提供）：候选人 Anthony J. Donate 博士是科罗拉多大学博尔德分校综合生理学系的心血管生理学家。多纳托博士的研究重点是介导人类血管衰老的机制，以及习惯性有氧运动如何在衰老过程中保持和恢复血管健康。该研究项目的目的是确定为期 12 周的有氧运动干预通过诱导氧化应激减少和一氧化氮生物利用度增加来恢复中老年男性和女性血管内皮功能的功效。拟议的研究将使用“综合”（系统到基因）方法来确定习惯性运动恢复该组内皮功能的细胞和分子机制，包括测量影响氧化应激、炎症和一氧化氮产生的蛋白质的血管内皮表达。预期结果应提供关于习惯性有氧运动改善中老年人血管内皮功能的综合生理机制的临床重要信息。