Physical Activity and Pelvic Floor Disorders

体力活动和盆底疾病

• 批准号: 7798490
• 负责人: INGRID E NYGAARD
• 金额: $ 31.45万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7798490
• 关键词: Address; Adult; Affect; Aftercare; Age; American; Body mass index; Case-Control Studies; Clinic; Cohort Studies; Data; Disease; Drops; Exercise; Extravasation; Foundations; Frequencies; Future; Health; Health Benefit; Hour; Household; Incidence; Lead; Leisure Activities; Long-Term Effects; Longitudinal Studies; Measures; Metabolic; Methods; Obesity; Occupational; Operative Surgical Procedures; Organ; Outcome; Outcome Measure; Participant; Pelvic Examination; Pelvic Floor Disorders; Pelvic floor structure; Pelvis; Physical activity; Population; Prevention; Primary Health Care; Prospective Studies; Ptosis; Questionnaire Designs; Questionnaires; Recurrence; Registries; Reporting; Research Personnel; Risk; Risk Factors; Scientist; Site; Strenuous Exercise; Stress Urinary Incontinence; Structure; Urinary Incontinence; Urine; Uterus; Vagina; Woman; Work; base; cohort; design; indexing; modifiable risk; public health relevance; urinary

DESCRIPTION (provided by applicant): Physical activity is crucial in maintaining health. Understanding how physical activity impacts pelvic floor disorders is important: half of American women have urinary incontinence or pelvic organ prolapse and one in nine undergoes surgery for these conditions. Studies to date find both protective and harmful effects of physical activity on pelvic floor disorders. The investigators, a multi-disciplinary team of urogynecologists, exercise scientists and statistician, believe this discrepancy is in large part due to inadequate ascertainment of both physical activity data and pelvic floor outcome measures. The primary aims of this study, addressed in two carefully designed case-control studies, are to determine, after adjusting for confounders, whether 1) moderate to severe stress urinary incontinence, defined by a validated questionnaire, and 2) pelvic organ prolapse, defined by structured pelvic examination, are associated with increased or decreased a) current leisure activity and b) total lifetime activity (leisure, household, and occupational). Participants will include 650 women, largely from primary care clinics: 175 with moderate to severe stress urinary incontinence, 175 with pelvic organ prolapse and 300 controls with neither condition frequency matched for age, body mass index and site. A secondary aim of this study is to establish, from the population screened for these studies, a registry of approximately 1,500 women with neither prolapse nor urinary incontinence; this will provide a foundation for future studies on the incidence of these conditions. Physical activity will be measured using validated questionnaires designed to assess current and cumulative lifetime activity in women; activity items will be supplemented with additional loading and impact physical activities. Lifetime physical activity amongst women with and without each condition will be compared using both MET hours/week (the most widely used and traditionally accepted method) and strenuous activity hours/week. PUBLIC HEALTH RELEVANCE: Pelvic floor disorders including urinary leakage and pelvic organ prolapse (dropping of pelvic organs such as the uterus into or out of the vagina) are very common. Limited data to date suggest that physical activity may be both helpful and harmful in terms of its effect on the pelvic floor. We will study the long-term effects of different levels of activity on pelvic floor disorders. Given the health benefits of activity, we believe that women should be encouraged to be active unless there is scientific evidence to the contrary.

描述（由申请人提供）：体育活动对于维持健康至关重要。了解体育锻炼如何影响骨盆底疾病很重要：一半的美国妇女患有尿失禁或骨盆器官脱垂，而九分之九的人在这些情况下接受了手术。迄今为止，研究发现体育活动对骨盆底疾病的保护性和有害影响。研究人员是泌尿妇女学家，运动科学家和统计学家的多学科团队，认为这种差异在很大程度上是由于确定了体育活动数据和骨盆底层结果指标。 The primary aims of this study, addressed in two carefully designed case-control studies, are to determine, after adjusting for confounders, whether 1) moderate to severe stress urinary incontinence, defined by a validated questionnaire, and 2) pelvic organ prolapse, defined by structured pelvic examination, are associated with increased or decreased a) current leisure activity and b) total lifetime activity (leisure, household, and occupational).参与者将包括650名女性，主要来自初级保健诊所：175个中度至重度尿液尿失禁，骨盆器官脱垂和300个对照，既不适合年龄，体重指数和现场的条件频率。 这项研究的次要目的是，从筛选的这些研究的人群中确定约1,500名既没有脱垂也不尿失禁的妇女的注册表；这将为未来研究这些疾病的发病率提供基础。将使用旨在评估女性当前和累积寿命活动的经过验证的问卷来衡量体育活动；活动项目将补充额外的负载和影响体育活动。使用MET小时/周（最广泛使用和传统上接受的方法）和每周剧烈的活动时间，将比较有或没有每种状况的女性的终身体育活动。公共卫生相关性：包括尿液泄漏和骨盆器官脱垂在内的骨盆底疾病（子宫等骨盆器官降低或从阴道降低）非常普遍。迄今为止，有限的数据表明，就其对骨盆底的影响而言，体育活动可能既有帮助又有害。我们将研究不同水平的活动对骨盆底疾病的长期影响。鉴于活动的健康益处，我们认为应该鼓励妇女保持活跃，除非有相反的科学证据。