Improving Effectiveness and Accuracy of Radiation Therapy

提高放射治疗的有效性和准确性

• 批准号: 7498507
• 负责人: Rebecca Maureen Howell
• 金额: $ 13.36万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-24 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498507
• 关键词: Address; Adverse effects; Algorithms; American Cancer Society; Area; Cancer Etiology; Cancer Patient; Cessation of life; Critiques; Diagnosis; Dose; Effectiveness; Goals; Individual; Intensity-Modulated Radiotherapy; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Measurement; Measures; Methods; Organ; Patients; Peripheral; Radiation; Radiation Oncologist; Radiation therapy; Rate; Reaction; Research; Research Methodology; Research Personnel; Skin; Therapeutic; Time; Tissues; Training Activity; United States; Work; anticancer research; base; cancer radiation therapy; cancer type; density; dosage; improved; interest; men; prescription document; prescription procedure; size

DESCRIPTION (provided by applicant): Introduction: Effectiveness of radiation therapy can be improved through increased accuracy in radiotherapy calculations. The proposed research will focus on two types of cancer, prostate and lung. The proposed prostate cancer research is an extension of earlier work while the lung cancer research is a new area of interest. Background: Treatment for prostate cancer is successful in most cases. Although 1 in 8 men will be diagnosed with prostate cancer, only 1 in 34 will die from prostate cancer (American Cancer Society). Research proposed in Specific Aims 1 and 2 focuses on decreasing adverse radiation side-effects by increasing the understanding of dose distributions and side effects from Intensity Modulated Radiation therapy (IMRT) for prostate cancer. The goal of this project is to provide Radiation Oncologists the necessary information to select the most appropriate beam energy for individual patients. Lung cancer is the leading cause of cancer death in the United States, approximately 6 out of 10 people with lung cancer die within 1 year of being diagnosed (American Cancer Society). Improving the therapeutic gains in lung cancer is imperative. Specific Aims 3 and 4 focus on improving the accuracy of dose calculations in lung cancer radiation therapy with the long term goal of understanding how much radiation dose is necessary to increase cure rates. Hypothesis: Increased accuracy in radiotherapy dose calculations can reduce adverse side effects from prostate cancer radiotherapy and can increase the therapeutic gain for lung cancer radiotherapy. Specific Aims: The following research aims will be addressed: (1) Perform skin dose measurements to evaluate skin reactions for prostate cancer patients treated with 6MV beam energy for IMRT; (2) Perform Monte Carlo calculations (in phantom) of dose to peripheral organs from IMRT, expandable to individual patient calculations; three years of protected time to facilitate her transition to an established cancer researcher. Her research plan is based on her previous work in improving the quantification of dosage effects for intensity-modulated radiotherapy (IMRT). The previous submission was primarily critiqued for lack of a full breadth of training activities and for brevity of research methods including a lack of statistical analyses methods and justification.

描述（由申请人提供）：简介：可以通过提高放射疗法计算的准确性来提高放射治疗的有效性。拟议的研究将侧重于两种类型的癌症，前列腺和肺。拟议的前列腺癌研究是早期工作的扩展，而肺癌研究是一个新的感兴趣领域。背景：在大多数情况下，前列腺癌的治疗成功。尽管八分之一的男性将被诊断出患有前列腺癌，但只有34分之一将死于前列腺癌（美国癌症协会）。特定目的1和2中提出的研究集中于通过增加对剂量分布的理解以及对前列腺癌的强度调制放射治疗（IMRT）的副作用来减少不良辐射副作用。该项目的目的是为辐射肿瘤学家提供必要的信息，以选择最适合个别患者的光束能量。肺癌是美国癌症死亡的主要原因，在被诊断后的1年内，有10人中约有6人死亡（美国癌症协会）。必须改善肺癌的治疗收益。具体目标3和4专注于提高肺癌放射治疗中剂量计算的准确性，其长期目标是了解增加辐射剂量以提高治疗速率。 假设：放疗剂量计算的准确性提高可以减少前列腺癌放射疗法的不良副作用，并可以增加肺癌放射疗法的治疗增加。具体目的：将解决以下研究目的：（1）进行皮肤剂量测量，以评估用IMRT治疗的6MV束能量治疗的前列腺癌患者的皮肤反应； （2）对IMRT的外围器官进行蒙特卡洛计算（幻影），可扩展到单个患者计算；三年的保护时间促进了她向已建立的癌症研究员的过渡。她的研究计划是基于她以前在改善强度调节放射疗法（IMRT）剂量效应定量的工作。先前的提交主要是因为缺乏全部培训活动以及简洁的研究方法，包括缺乏统计分析方法和理由。