The Effects of Sleep Deprivation on Drug Craving and Cue-Reactivity

睡眠不足对药物渴望和提示反应的影响

• 批准号: 7511801
• 负责人: GEORGE H TRKSAK
• 金额: $ 12.37万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7511801
• 关键词: Acute; Area; Attention; Behavior; Behavioral; Brain; Brain imaging; Chronic; Clinical; Cues; Dependence; Drug Addiction; Drug abuse; Drug usage; EP300 gene; Electroencephalogram; Event-Related Potentials; Exhibits; Functional Magnetic Resonance Imaging; Goals; Heart Rate; Imaging technology; Incidence; Individual; Investigation; Laboratory Research; Literature; Magnetic Resonance; Magnetic Resonance Imaging; Marijuana; Measurement; Measures; Medicine; Mentored Research Scientist Development Award; Mentors; Methods; Participant; Patient Self-Report; Patients; Pattern; Persons; Pharmaceutical Preparations; Physiological; Population; Rate; Relapse; Reporting; Research; Research Personnel; Research Training; Signal Transduction; Skin Temperature; Sleep; Sleep Deprivation; Sleep Disorders; Techniques; Testing; Training; blood oxygen level dependent; brain electrical activity; craving; design; drug abstinence; drug craving; indexing; insight; response; reward circuitry; skills; treatment program

DESCRIPTION (provided by applicant): This 5-year K01 Mentored Research Scientist Development Award integrates an extensive Training and Research Plan. The candidate is in need of additional mentored training to become an independent researcher in the area of brain imaging, sleep medicine and drug abuse. Hence, the Training Plan combines comprehensive training in clinical laboratory research, sleep recording techniques, and functional magnetic resonance imaging (fMRI) technology. The Research Plan is designed to help the candidate implement the skills outlined in the training plan and proposes to examine the effects of sleep deprivation on cue-reactivity and subjective drug craving by collecting electroencephalogram measures of event-related potentials and fMRI blood-oxygen-level-dependent brain activation patterns in a population of marihuana-dependent persons. Both the acute and chronic use and abuse of drugs impact sleep, but the literature currently lacks reports of rigorous investigations of the impact of sleep deprivation on indices of drug use, craving, and relapse. The experimental goals would test the hypothesis that sleep deprivation in marihuana-dependent subjects results in enhanced cue-reactivity and/or subjective drug craving and subsequent differences in regional activation patterns in specific brain reward circuitry. This is an important research objective as enhanced drug cue-reactivity and craving following sleep deprivation may perpetuate drug-taking behavior and/or increase the incidence of relapse. The implications of these findings may suggest that more attention may need to be paid to a patient's sleep disorders in developing effective treatments for drug dependence. Drug craving and the physiological response to drug-related cues are contributing factors to drug taking behavior and relapse in drug abstinence. The proposed Research Plan would test whether sleep deprivation in marihuana-dependent individuals increases their response to marihuana-related pictures using electroencephalogram (EEG) measurements of brain electrical activity and functional magnetic resonance brain imaging. The findings would show the strong relationship between sleep loss and drug craving that is of great importance in developing effective drug treatment strategies and may provide insight to those struggling with drug abuse and/or dependence in understanding the contribution of sleep/wake patterns to their drug-taking behavior.

描述（由申请人提供）：这项为期5年的K01指导研究科学家发展奖将广泛的培训和研究计划整合在一起。候选人需要额外的指导培训，以成为脑成像，睡眠医学和药物滥用领域的独立研究人员。因此，培训计划结合了临床实验室研究，睡眠记录技术和功能磁共振成像（fMRI）技术的全面培训。该研究计划旨在帮助候选人实施培训计划中概述的技能，并提议通过收集与事件相关潜力的电脑透明图测量和FMRI血液氧气级依赖性依赖于Marihuana依赖人依赖的人群的依赖于事件相关的潜力的电脑相关潜力的电脑相关潜力和FMRI血氧级依赖性大脑激活模式，以研究睡眠剥夺对提示反应性和主观药物的渴望的影响。急性和长期使用和滥用药物都会影响睡眠，但目前文献缺乏对睡眠剥夺对吸毒，渴望和复发指数的影响进行严格调查的报道。实验目标将检验以下假设：大麻依赖性受试者中的睡眠剥夺导致提高提示反应性和/或主观药物渴望以及随后在特定脑奖励电路中区域激活模式的差异。这是一个重要的研究目标，因为在睡眠不足之后增强的药物提示反应性和渴望可能会使吸毒行为永久化和/或增加复发的发生率。这些发现的含义可能表明，可能需要更多注意患者的睡眠障碍，以开发有效的药物依赖治疗方法。药物渴望和对药物相关提示的生理反应是药物服用行为和药物戒烟复发的因素。提出的研究计划将使用脑电图（EEG）测量大脑电活动和功能磁共振脑成像的测量结果来测试大麻依赖性个体的睡眠剥夺是否会增加对与大麻相关图片的反应。这些发现将表明睡眠丧失与渴望药物之间的牢固关系，这在制定有效的药物治疗策略中非常重要，并可能为那些在了解毒品滥用和/或依赖性方面的洞察力，以理解睡眠/唤醒模式对其吸毒行为的贡献。