Administrative core

行政核心

• 批准号: 10540796
• 负责人: Anita Sil
• 金额: $ 23.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10540796
• 关键词: Area; Arizona; Basic Science; Biological Models; Biology; Chronic; Clinical; Clinical Investigator; Coccidioides; Coccidioidomycosis; Collaborations; Communicable Diseases; Core Facility; Cytometry; Data; Development; Diagnostic; Disease Progression; Elements; Ensure; Feedback; Fostering; Funding; Genetic; Goals; Immune response; Immunology; Infection; Leadership; Meningitis; Mentors; Metabolic; Metagenomics; Microbiology; Molecular Biology; Mucosal Immunity; Neurologist; Occupational activity of managing finances; Participant; Pathogenesis; Pathway interactions; Patient Care; Patients; Persons; Physicians; Productivity; Research; Research Personnel; Sampling; Scientist; Seasons; Subgroup; Technology; Teleconferences; The science of Mycology; Therapeutic; Universities; Vaccine Design; Virulence; combat; fungus; infectious meningitis; insight; meetings; member; mutant; next generation sequencing; novel; pathogen; programs; recruit; single-cell RNA sequencing; success; synergism; transcriptomics

Project Summary (Core 1, Administrative Core, Sil) Our goal is to establish a vibrant and productive Coccidioidomycosis Collaboration Research Center (CCRC) entitled Molecules and Pathways at the Coccidioides Host-Pathogen Interface. We are bringing together a cadre of basic scientists, clinical investigators, and technologists who will interrogate the pathogenesis of Coccidioides and the nuances of the host response in model systems, in chronic coccidiomycosis, and in coccidioidal meningitis. Taken together, we will provide insights that will bridge gaps in diagnostics, therapeutics, and potentially vaccine design for coccidioidomycosis. The Administrative Core is key to integrating the findings of each project, fostering synergy between our groups, and recruiting junior investigators to the coccidioidomycosis field via the mentored Developmental Research Program initiative. We will provide scientific, organizational, and administrative leadership as well as financial oversight. Scientific progress will be fostered and evaluated by extensive review of data at quarterly meetings attended by all of the CCRC members. In addition, we will have an annual in-person meeting for all participants. All investigators affiliated with each project and core will evaluate the scientific progress of each group and give constructive feedback that will support trainee development while fostering scientific excellence. Additionally, if this CCRC is funded, we will establish an external scientific advisory board (SAB) comprised of experts in basic mycology, microbiology, immunology of fungi, infectious disease, and host response. Thus we expect a unique synergy between all elements of this proposal that will allow us to support both seasoned and junior investigators in the Coccidioides field and make novel and critical contributions to diagnostic and therapeutic strategies to combat coccidioidomycosis.

项目摘要（核心 1、管理核心、Sil） 我们的目标是建立一个充满活力和富有成效的球孢子菌病合作研究中心 （CCRC）题为球孢子菌宿主-病原体界面的分子和途径。我们带来 由基础科学家、临床研究人员和技术人员组成的骨干队伍将共同探讨发病机制 球孢子菌和模型系统、慢性球孢子菌病和在模型系统中宿主反应的细微差别 球孢子菌脑膜炎。总而言之，我们将提供弥合诊断、治疗、 以及球孢子菌病的潜在疫苗设计。 行政核心是整合每个项目的研究结果、促进我们之间的协同作用的关键 小组，并通过指导的发展招募初级研究人员进入球孢子菌病领域 研究计划倡议。我们将提供科学、组织和行政领导以及 财务监督。将通过每季度对数据进行广泛审查来促进和评估科学进步 CCRC全体委员参加的会议。此外，我们还将为所有人举行年度面对面会议 参与者。与每个项目和核心相关的所有研究人员将评估每个项目的科学进展 小组并提供建设性反馈，以支持受训者的发展，同时促进科学卓越。 此外，如果该 CCRC 得到资助，我们将建立一个外部科学顾问委员会 (SAB)，其成员包括 基础真菌学、微生物学、真菌免疫学、传染病和宿主反应方面的专家。因此我们 期望该提案的所有要素之间产生独特的协同作用，这将使我们能够支持经验丰富的和 球孢子菌领域的初级研究人员，为诊断和治疗做出了新颖且关键的贡献 对抗球孢子菌病的治疗策略。