Children of Depressed Mothers

抑郁母亲的孩子

• 批准号: 7684111
• 负责人: ZACHARY N STOWE
• 金额: $ 12.84万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7684111
• 关键词: Address; Adolescent; Age; Age-Months; Antidepressive Agents; Anxiety; Appointment; Area; Back; Behavior; Behavioral; Biological; Birth; Child; Comorbidity; Corticosterone; Data; Development; Diagnostic; Discipline of obstetrics; Early Intervention; Early-life trauma; Etiology; Event; Exhibits; Funding; Gender; Genetic Predisposition to Disease; Guidelines; HPSE gene; Heart Rate; Hippocampus (Brain); Hydrocortisone; Hyperactive behavior; Incidence; Infant; Intervention; Investigation; Laboratories; Laboratory Animals; Lactation; Life; Literature; Major Depressive Disorder; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Modeling; Mood Disorders; Morbidity - disease rate; Mothers; NIH Program Announcements; Neonatal; Neurosciences; Noise; Numbers; Participant; Perinatal; Personal Satisfaction; Pharmaceutical Preparations; Physiological; Population Study; Postpartum Period; Pregnancy; Pregnancy Complications; Pregnant Women; Problem behavior; Psychopathology; Psychophysiology; Psychosocial Stress; Rate; Rattus; Recording of previous events; Relapse; Reporting; Research; Research Design; Research Personnel; Risk; Role; Salivary; Sampling; Seminal; Sex Characteristics; Specialized Center; Stimulus; Stress; Stressful Event; Testing; Toxic Environmental Substances; Upper arm; Urination; Visit; Walkers; Woman; base; behavior measurement; biobehavior; biological adaptation to stress; cohort; depressive symptoms; design; environmental stressor; experience; fetal; follow-up; hypothalamic-pituitary-adrenal axis; infant outcome; maternal depression; novel; postnatal; prenatal; prenatal stress; prescription document; prescription procedure; programs; prospective; response; restraint; sex; statistics; stressor; therapy development

The primary focus of this project is to measure stress reactivity in infants of mothers' with major depression, a form of ELS, in a controlled laboratory setting. The literature is replete with studies of the effects of maternal depression, anxiety, and stress on infant well-being that includes >32,000 mother-infant pairs. Studies in infants with genetic vulnerability for affective disorders have been reported to have lower vagal tone, as well as higher salivary cortisol concentrations following lab tasks, when compared with control infants. There appears to be a mismatch between their passive or nonreactive behaviors, and their supersensitive physiological responses to stress. Remarkably, there are few investigations that have measured behavioral and psychophysiological functioning of infants of depressed mothers in response to controlled laboratory stress stimuli, and no study of this type has controlled for maternal co-morbid anxiety, maternal medications in pregnancy and/or lactation, obstetrical events, early life trauma and recent maternal stressful life events. This study is designed to further this important area of research by assessing behavioral and cortisol stress reactivity of infants of women with a history of major depression at six months of age. The prospective assessment of psychiatric morbidity during pregnancy and the postpartum period, comorbid anxiety, obstetric complications,early life trauma and maternal stressful life events will address the sparse date regarding maternal factors mediating infant reactivity. The study population will include 25 infants of women with no history of depression to serve as controls, that will be compared to infants from three age matched cohorts; 1) Women undergoing antidepressant treatment (monotherapy) for major depression during pregnancy and the postpartum period; 2) Women with a history of prenatal depression who choose not to take antidepressants; and 3) Women with a history of major depression who remain euthymic during pregnancy without antidepressant exposure. These later cohorts will be derived from ongoing NIH-funded investigations (Specialized Center of Research on Sex and Gender Effects focusing on PK/PD Modeling in Pregnancy and focusing on predictors of relapse of Depression during the Postpartum). At six months of age the infants will be exposed to laboratory stressors (noise burst, arm restraint), and their behavioral and physiological reactivity (heart rate variability, salivary cortisol) will be assessed. The novelty of these data is enhanced by the pre-natal and postnatal prospective assessment of variables that could influence response to these stressors.

该项目的主要重点是在受控的实验室环境中衡量患有严重抑郁症的母亲的婴儿的压力反应性。文献充满了对母亲抑郁，焦虑和压力对婴儿健康的影响的研究，其中包括> 32,000个母亲。据报道，与对照婴儿相比，在实验室任务后，对具有情感障碍遗传脆弱性的婴儿的研究较低，唾液皮质醇浓度较高。他们的被动或无反应行为与他们对压力的超敏感反应之间似乎是不匹配的。值得注意的是，很少有研究测量了抑郁母亲的婴儿对受控的实验室压力刺激的行为和心理生理学功能，并且对这种类型的研究没有任何研究控制着母亲的孕妇焦虑，孕妇的孕妇药物，妊娠和/或哺乳，哺乳，早期的生命，早期的孕产妇和孕产妇的压力生活。这项研究旨在通过评估六个月大的患有严重抑郁症的妇女的婴儿的行为和皮质醇应激反应性来进一步研究这一重要的研究领域。怀孕期间和产后期间精神病发病率的预期评估，合并症，产科并发症，早期生命创伤和孕产妇压力的生活事件将解决稀疏的日期 关于介导婴儿反应性的母体因素。该研究人群将包括25名没有抑郁史的女性，可以作为对照，这将与三个年龄段的同伙的婴儿进行比较。 1）在怀孕期间和产后期间接受抗抑郁药治疗（单一疗法）的妇女； 2）有产前抑郁症的妇女选择不服用抗抑郁药； 3）具有严重抑郁史的妇女在怀孕期间仍然没有抗抑郁药暴露。这些后来的人群将来自正在进行的NIH资助的研究（有关性别和性别效应的专业研究中心，重点是妊娠中PK/PD建模，并着重于产后抑郁症复发的预测指标）。在六个月大时，婴儿将暴露于实验室压力源（噪声爆发，手臂约束），并评估其行为和生理反应性（心率变异性，唾液皮质醇）。这些数据的新颖性通过对可能影响对这些压力源的反应的变量的前瞻性评估增强。