Engineering Core

工程核心

基本信息

批准号：
10525431
负责人：
Jeff W Lichtman
金额：
$ 17.31万
依托单位：
HARVARD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10525431
关键词：
Animals Behavior Behavioral Brain Calcium Cardiovascular system Computer software Custom Data Analyses Devices Electron Microscopy Electrophysiology (science)Engineering Environment Equipment Generations Goals Heart Image Laboratories Maps Microscope Mind Modeling Movement Neurosciences Neurosciences Research Optics Oxygen Pathway interactions Postdoctoral Fellow Regulation Reproducibility Research Role Savings Science Scientist Stretching Students Swimming System Testing Training and Education United States National Institutes of Health Zebrafish base connectome cost effective cost effectiveness data acquisition design design and construction experimental study instrumentation laboratory experience machine vision meetings member microscopic imaging millimeter mind body interaction neural circuit novel prototype relating to nervous system student training two-photon

项目摘要

Engineering Core The goal of the Engineering Core is to enable our Team members to surmount their most challenging technological and engineering obstacles. There are many needs for engineering solutions in our proposal -- from behavioral apparatus to optical and electrophysiological rigs, to software for data acquisition and analyses. Even the most technologically sophisticated of the research groups in our Team require special assistance with engineering problems in order to achieve our ambitious aims. In the Center for Brain Science at Harvard there is an existing Engineering Core that consists of (a) an integrated laboratory to design, prototype, iterate, and produce custom devices for neuroscience experiments and (b) Dr. Brett Graham, an engineer-neuroscientist who solves the most challenging engineering problems in the user laboratories and trains young scientists to do this themselves. By adding a dedicated staff engineer, the Engineering Core is able to support the team-based neuroscience research proposed here. The specific aims are to implement engineering solutions to problems faced by the Projects and other Cores. The Engineering Core will (a) design and build apparatuses to image rapidly swimming larval zebrafish; (b) build rigs to record neural activity in larval zebrafish brains and hearts via calcium imaging; and (c) further automate the connectomics imaging pipeline.

工程核心工程核心的目标是使我们的团队成员能够克服最具挑战性的挑战技术和工程障碍。我们的提案中有很多工程解决方案的需求—— 从行为仪器到光学和电生理学装置，再到数据采集和分析软件分析。即使我们团队中技术最先进的研究小组也需要特殊的协助解决工程问题，以实现我们的宏伟目标。在脑科学中心在哈佛大学，现有的工程核心包括 (a) 一个综合实验室，用于设计、原型制作、迭代和生产神经科学定制设备实验和 (b) Brett Graham 博士，一位工程师兼神经科学家，解决了当今最具挑战性的工程问题用户实验室并培训年轻科学家自己做这件事。通过增加一名专门的工程师，工程核心能够支持基于团队的神经科学此处提出的研究。具体目标是针对所面临的问题实施工程解决方案项目和其他核心。工程核心将 (a) 设计和构建快速成像的设备游泳的斑马鱼幼体； (b) 建立设备来记录斑马鱼幼虫大脑和心脏的神经活动钙成像； (c) 进一步实现连接组学成像流程的自动化。