MENTORED PATIENT-ORIENTED RESEARCH TOWARDS OPTIMIZING CARDIOVASCULAR OUTCOMES IN CHRONIC KIDNEY DISEASE

指导以患者为导向的研究，以优化慢性肾脏病的心血管结果

基本信息

批准号：
10525521
负责人：
Sankar Dass Navaneethan
金额：
$ 11.82万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-15 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10525521
关键词：
Adoption Affect Agonist Albumins Albuminuria Angiotensin Receptor Angiotensin-Converting Enzyme Inhibitors Area Biological Markers Cardiac Cardiovascular Diseases Cardiovascular system Chronic Kidney Failure Clinical Clinical Practice Guideline Clinical Research Clinical Trials Creatinine Data Diabetes Mellitus Diagnostic Disease Progression Documentation EFRAC Educational workshop End stage renal failure Enrollment Event Faculty Functional disorder Future GLP-I receptor Glucose Goals Guidelines Health system Heart Atrium Heart failure High Prevalence Hospitalization Hypertension Hypoglycemic Agents Inflammation Institution International Intervention Studies Kidney Kidney Diseases Kidney Failure Leadership Learning Left Lung Medical Students Medicine Mentors Metabolic Diseases Midcareer Investigator Award in Patient-Oriented Research Morbidity - disease rate Nephrology Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Oxidative Stress Patients Pattern Pharmaceutical Preparations Placebos Population Pulmonary Hypertension Renal dialysis Renal function Reporting Research Research Activity Research Infrastructure Research Personnel Research Project Grants Risk Risk Factors Role Sodium Testing Therapeutic Therapeutic Agents Time Toxin Tubular formation Vascular calcification Ventricular Veterans Health Administration advanced disease aged burden of illness cardiovascular risk factor clinical practice college diabetic endothelial dysfunction epidemiology study experience follow-up improved improved outcome inhibitor interest lung pressure mortality mortality risk non-diabetic novel therapeutics patient oriented research pressure professor pulmonary arterial pressure research study skills symporter systematic review uptake urinary

项目摘要

PROJECT SUMMARY This application is for a K24 Midcareer Investigator Award in Patient-Oriented Research for Dr. Sankar Navaneethan. He is a Professor of Medicine and Director of Clinical Research in the Section of Nephrology, at Baylor College of Medicine. Dr. Navaneethan’s research projects have focused on improving cardiovascular and kidney outcomes for those with and at risk of chronic kidney disease (CKD). He has extensive experience in epidemiological investigations, clinical trials, and systematic reviews. Over the past decade, he has mentored trainees at different levels including medical students, residents, fellows, and junior faculty on various patient-oriented research studies. Current proposal would help him achieve following goals: a) dedicate additional time to mentor young investigators in various patient-oriented research projects related to cardiovascular disease in kidney disease, b) learn new skills in mentoring skills through both formal courses and workshops and interactions from mentors within and outside his institution, c) enhance ongoing patient- oriented research activities in obesity and impact of other metabolic diseases on cardiovascular disease in CKD population, d) to identify new scientific areas of patient-oriented research that are critical to improvement in cardiovascular outcomes of CKD population, and e) to develop leadership skills. Proposed research projects by the applicant over the 5-years would help understand the uptake of and barriers in the adoption of cardio- kidney protective medications among those with kidney disease and investigate the potential role of sodium- glucose cotransporter-2 inhibitors (SGLT2i) in improving outcomes of those with pulmonary hypertension. These projects would utilize and expand PI’s current research infrastructure and provide data for future interventional studies. Aim of the first project is to study the pattern of initiation and uptake of SGLT2i and glucagon-like peptide-1 receptor agonists (GLP-1RA) among those with kidney disease using data collected from the Veterans Affairs health system. Objectives of the second project is to conduct a pilot non-randomized study to examine the effects of SGLT2i on pulmonary artery pressure in those with CKD.

项目概要此申请适用于 Sankar 博士的以患者为导向的研究领域的 K24 职业生涯中期研究员奖 Navaneethan 是该大学肾脏科的医学教授兼临床研究主任。贝勒医学院 Navaneethan 博士的研究项目重点是改善心血管。他拥有丰富的经验。在过去的十年里，他在流行病学调查、临床试验和系统评价方面取得了巨大的成就。指导不同级别的学员，包括医学生、住院医生、研究员和初级教师目前的提案将帮助他实现以下目标：a) 致力于额外的时间指导年轻研究人员参与各种以患者为中心的研究项目心血管疾病和肾脏疾病，b) 通过两个正式课程学习指导技能的新技能以及机构内外导师的研讨会和互动，c) 加强持续的患者- 肥胖和其他代谢疾病对心血管疾病影响的定向研究活动 CKD 人群，d) 确定对改善至关重要的以患者为中心的研究的新科学领域 e) 发展拟议的研究项目。申请人在过去 5 年的研究将有助于了解有氧运动的采用和采用的障碍肾病患者的肾脏保护药物，并研究钠的潜在作用葡萄糖协同转运蛋白 2 抑制剂 (SGLT2i) 可改善肺动脉高压患者的预后。这些项目将利用和扩展 PI 当前的研究基础设施，并为未来提供数据第一个项目的目的是研究 SGLT2i 的启动和摄取模式。使用收集的数据在肾病患者中使用胰高血糖素样肽 1 受体激动剂 (GLP-1RA) 第二个项目的目标是进行非随机试点。研究检查 SGLT2i 对 CKD 患者肺动脉压的影响。