MRI OF BRAIN STRUCTURE AND PERFUSION

脑结构和灌注 MRI

• 批准号: 7471171
• 负责人: MICHAEL W WEINER
• 金额: $ 24.29万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-15 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7471171
• 关键词: Accounting; Alzheimer' s Disease; Amyloid; Anisotropy; Arteriosclerosis; Arts; Atrophic; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrovascular Trauma; Cognition; Collaborations; Data; Diffusion Magnetic Resonance Imaging; Epidemiologic Studies; Future; Goals; Hippocampus (Brain); Image; Image Analysis; Imaging Techniques; Impaired cognition; Impairment; Incidence; Infarction; Lesion; Light; Magnetic Resonance Imaging; Measurement; Measures; Memory; Memory impairment; Modeling; Multimodal Imaging; Outcome; Pathology; Perfusion; Population; Prevention; Process; Rate; Resolution; Retinal; Risk Factors; Scanning; Site; Spin Labels; Stroke; Structure; Testing; Thick; Weight; Work; base; cerebral atrophy; cerebrovascular; cognitive function; design; executive function; frontal lobe; gray matter; hippocampal atrophy; interest; intima media; neuron loss; uptake; white matter

The overall goals of this project are 1) to determine the extent to which arteriosclerosis (measured by C-IMT, R-AV ratio) is associated with changes of brain perfusion, and the volume and integrity of gray matter (GM) and white matter (WM) and 2) the extent to which this association relates to the changes in brain and cognition caused by Alzheimer's disease pathology. This project will use state of the art MRI at high field to measure changes occurring in the brains of 470 subjects with two or more scans in 260 subjects. Data will include structural MRI to measure gray matter and white matter lesions (WMLs), hippocampal subfields, arterial spin labeled perfusion (ASL) MRI to quantify cerebral blood flow, and diffusion tensor imaging (DTI) to quantify measures of integrity of white matter tracts. Image analysis will use: registration and spatial normalization, segmentation, tractography, voxel based analyses and region of interest selection, to test statistically the following hypotheses cross sectionally and longitudinally (prediction of change in the outcome variable): 1.) Arteriosclerosis correlates with reduced brain perfusion, WMLs and lacunar infarcts, GM atrophy, and reduced fractional anisotropy of WM tracts, especially the superior longitudinal fasciculus and the occipital frontal tracts. 2.) White matter lesions (WMLs, especially periventricular WMLs in the frontal lobe) and lacunar infarcts correlate with reduced perfusion of frontal lobe and reduced FA of white matter tracts, especially the superior longitudinal fasciculus and occipital frontal tract. 3.) Atrophy of hippocampal subfields (a marker of AD pathology) correlates with reduced perfusion of the posterior cingulate GM and reduced FA of the cingulum tract WM. 4.) Regions of: frontal lobe perfusion, FA of frontal lobe white matter, and volume frontal lobe GM correlate with executive function while hippocampal volumes, posterior cingulate perfusion, and FA of cingulum tract correlate with memory function. Finally, we will explore the relationship of PIB uptake (amyloid load), and FDG uptake, to the structural, perfusion, and DTI changes detected by MRI.

该项目的总体目标是1）确定动脉硬化的程度（由C-IMT测量， R-AV比）与大脑灌注的变化以及灰质的体积和完整性有关（GM） 和白质（WM）和2）该关联与大脑和大脑变化的程度 阿尔茨海默氏病病理学引起的认知。该项目将在高场上使用Art MRI的状态 测量470名受试者的大脑中发生的变化，并在260名受试者中进行了两次或更多扫描。数据将 包括测量灰质和白质病变（WML），海马子场的结构MRI， 动脉自旋标记的灌注（ASL）MRI，以量化脑血流和扩散张量成像（DTI） 量化白质区域完整性的度量。图像分析将使用：注册和空间 归一化，分割，拖拉机，基于体素的分析和感兴趣的选择区域，以测试 从统计学上讲，以下假设横截面和纵向（预测变化的变化 结果变量）： 1.）动脉硬化与大脑灌注，WML和lacunar梗死，GM萎缩和 WM区域的分数各向异性降低，尤其是上纵向筋膜和枕骨 额叶。 2.）白质病变（WML，尤其是额叶周围的WML）和lacunar梗塞 与额叶灌注减少和白质区域的FA减少相关，尤其是上司 纵向筋膜和枕骨额叶。 3.）海马子场的萎缩（AD病理学的标记）与灌注的减少相关 后扣带回GM和扣带WM的FA减少。 4.）区域：额叶灌注，额叶白色物质的FA和额叶额叶GM相关 具有执行功能，同时海马体积，后扣带回灌注和cingulum Tract的Fa 与内存功能相关。 最后，我们将探索PIB摄取（淀粉样蛋白负载）和FDG摄取的关系， 灌注和MRI检测到的DTI变化。