Testing Effective Methods to Recruit Sexual and Gender Minority Cancer Patients for Cancer Studies

测试招募性少数癌症患者进行癌症研究的有效方法

基本信息

批准号：
10515913
负责人：
B R Simon Rosser
金额：
$ 67.99万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-12 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10515913
关键词：
Accounting Address Advertising Affect Alcohol abuse Area Attitude Belief Bisexual Cancer Burden Cancer Patient Cancer Survivor Caring Clinic Clinic Visits Comparative Study Computerized Medical Record Conceptions Cybersex Data Data Sources Development Discrimination Ethnic Origin Exclusion Face Female Gays Gender Gender Identity HIV Heterosexuals Intervention Trial Interview Lesbian Gay Bisexual Transgender Literature Malignant Neoplasms Malignant neoplasm of prostate Measures Mental Health Methodology Methods Minority Health Research Patient Recruitments Patients Performance Persons Population Primary Prevention Professional Organizations Protocols documentation Race Rehabilitation therapy Reporting Research Research Personnel Sampling Second Primary Cancers Sex Orientation Sexual and Gender Minorities Shapes Site Smoking Social support Structure Subgroup Surveys Survivors Telephone Testing Time Treatment outcome Underserved Population United States National Institutes of Health Woman Work Workload advanced disease anticancer research base cancer care cancer health disparity cancer risk cancer therapy cancer type care delivery cis-female cis-male cisgender comparison group cost design effectiveness testing evidence base experience gender minority gender minority group health disparity informant intersectionality male men minority stress neglect novel patient population patient stratification perceived discrimination prevent recruit research study satisfaction sex sexual minority sexual minority men sexual minority women social social stigma sociodemographics success theories transgender willingness

项目摘要

Abstract Recently, NCI called for research to effectively study small or rare populations relevant to cancer research. Sexual and gender minorities (SGM) are small populations at disproportionate risk for cancer but who have been under-researched in cancer studies. The principal challenge common across lesbian, gay, bisexual, and transgender populations is to develop effective methods to identify and recruit patients and survivors who are SGM into NCI cancer studies. Two technical advances have transformative potential to advance research on health disparities in SGM cancer patients. First, online recruitment has yielded large SGM samples in other areas of research (e.g., HIV primary prevention), but using online methods to recruit SGM cancer patients has not been rigorously studied. Second, cancer clinics have begun to include sexual orientation and gender identity (SOGI) data in the electronic medical record, but we need to test protocols on how to recruit SGM cancer patients using this data source. This application is based upon our recent success in overcoming challenges to recruit over 400 gay and bisexual prostate cancer patients into an R01 intervention trial of tailored rehabilitation for this population. We will replicate and expand upon these clinic-based and online methods to study how to recruit three small SGM populations – (1) sexual minority cisgender men, (2) sexual minority cisgender women, and (3) transgender and gender non-binary cancer patients - into cancer research studies. We have three specific aims. In Aim 1, we will document, in depth, SGM’s attitudes towards participating in NIH cancer research, identifying the facilitators and barriers that each group reports influences their willingness to participate. We will also investigate any impact poor cancer care and discrimination has on research participation. We will investigate these in cisgender SM men, cisgender SM women and gender minority cancer patients (n=15 per group) and compare experiences within these small populations and between SGM and a cisgender, heterosexual patient comparison group. In Aim 2, we will test the effectiveness, efficiency, cost, and workload in using two clinic SOGI-based strategies and three online strategies to recruit SGM small populations (150 each) compared to recruiting a sample of cisgender, heterosexual cancer patients. We predict size of the small population will negatively correlate with work, cost, and time involved, but positively correlate with yield. In Aim 3, we will conduct an online quantitative survey of willingness to participate in cancer research with 450 SGM cancer patients (150 per group) versus a cisgender heterosexual group (150 men and 150 women). Key measures assess facilitators and barriers to participation in NIH cancer research. To advance measures, we will assess performance of each group on five validated cancer scales to compare cancer care experience, discrimination in treatment, and outcomes. Finally, we will integrate and triangulate findings and assess intersectionality with race/ethnicity. This study will establish what recruitment strategies are effective across SGM populations, and which may be specific to each subgroup.

抽象的最近，NCI 呼吁开展有效研究与癌症研究相关的小规模或稀有人群的研究。性少数群体 (SGM) 是指患癌症风险不成比例但患有癌症的少数群体癌症研究中普遍存在的主要挑战是女同性恋、男同性恋、双性恋和异性恋。跨性别人群的目标是制定有效的方法来识别和招募患有以下疾病的患者和幸存者： SGM 融入 NCI 癌症研究中的两项技术进步具有推动癌症研究的变革潜力。首先，在线招募在其他癌症患者中产生了大量的 SGM 样本。研究领域（例如艾滋病毒初级预防），但使用在线方法招募 SGM 癌症患者其次，癌症诊所已经开始考虑性取向和性别。电子病历中的身份（SOGI）数据，但我们需要测试如何招募 SGM 的协议使用此数据源的癌症患者该应用程序是基于我们最近成功克服的。招募 400 多名同性恋和双性恋前列腺癌患者参加 R01 干预试验的挑战我们将复制并扩展这些基于诊所和在线的康复服务。研究如何招募三个小型 SGM 人群的方法 – (1) 性少数顺性别男性，(2) 性少数少数顺性别女性，以及 (3) 跨性别者和非二元性别癌症患者 - 参与癌症研究我们的研究有三个具体目标，在目标一中，我们将深入记录SGM的态度。参与 NIH 癌症研究，确定每个小组报告影响的促进因素和障碍我们还将调查他们是否愿意参与癌症护理和歧视的任何影响。我们将对顺性别 SM 男性、顺性别 SM 女性和性别进行调查。少数癌症患者（每组 n=15）并比较这些小群体的经验在目标 2 中，我们将测试 SGM 与顺性别、异性恋患者对照组之间的差异。使用两种基于 SOGI 的诊所策略和三种在线策略的有效性、效率、成本和工作量与招募顺性别样本相比，招募 SGM 小群体（每个 150 人）的策略，我们预测异性恋癌症患者的规模将与工作、成本、和所涉及的时间，但与产量呈正相关。在目标 3 中，我们将进行在线定量调查。愿意参与 450 名 SGM 癌症患者（每组 150 名）与顺性别患者的癌症研究异性恋群体（150 名男性和 150 名女性）主要措施评估参与的促进因素和障碍。在 NIH 癌症研究中，为了推进措施，我们将评估每个小组在五个经过验证的方面的表现。癌症量表来比较癌症护理经验、治疗中的歧视和结果。整合和三角测量研究结果并评估与种族/民族的交叉性本研究将确定什么。招募策略在 SGM 人群中有效，并且可能针对每个亚组。