MyPEEPS Mobile LITE: Limited Interaction Efficacy Trial of MyPEEPS Mobile to Reduce HIV Incidence and Better Understand the Epidemiology of HIV among YMSM

MyPEEPS Mobile LITE：MyPEEPS Mobile 的有限交互功效试验可降低 YMSM 中的 HIV 发病率并更好地了解 HIV 流行病学

• 批准号: 10462265
• 负责人: Dustin T Duncan
• 金额: $ 180万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462265
• 关键词: 18 year old; AIDS prevention; Accounting; Address; Advertisements; Advertising; Affect; Age; Age-Years; Alcohol consumption; Anxiety; Behavior; Behavioral Model; Bisexual; Black race; Clinical Trials; Code; Cohort Studies; Communities; Crime; Data; Discrimination; Enrollment; Epidemic; Epidemiology; Ethnic Origin; Evidence based intervention; Facebook; Frequencies; Funding; Future; Gays; Geographic Locations; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV diagnosis; HIV risk; Hot Spot; Incidence; Individual; Individual Differences; Institution; Intervention; Intervention Studies; Knowledge; Latino; Literature; Measures; Mediator of activation protein; Mental Depression; Methods; Modeling; Motivation; Neighborhoods; Outcome; Participant; Persons; Phase; Policies; Population; Positioning Attribute; Poverty; Prevalence; Prevention Research; Principal Investigator; Public Policy; Race; Randomized; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Risk; Risk Reduction; Rural; Same-sex; Sample Size; Sampling; Science; Self Efficacy; Techniques; Testing; Time; Treatment Efficacy; Twitter; United States; United States National Institutes of Health; Unsafe Sex; arm; base; behavior change; cisgender; cohort; condomless anal sex; digital; efficacy testing; efficacy trial; epidemiology study; ethnic diversity; evidence base; experience; health care service; health seeking behavior; high risk; human old age (65+); innovation; innovative technologies; intervention effect; intimate partner violence; longitudinal analysis; mHealth; male; men who have sex with men; minority children; peer; pre-exposure prophylaxis; preventive intervention; racial and ethnic; racial diversity; recruit; research study; response; retention rate; seroconversion; sexual minority; sexual risk behavior; social; social media; social stigma; standard of care; substance use; success; theories; therapy development; transmission process; tribal lands; uptake; virtual; young men who have sex with men

PROJECT SUMMARY There is a critical need to better understand the epidemiology of HIV acquisition in the United States (US), particularly among cisgender gay, bisexual and other men who have sex with men (MSM), one of the key populations essential to target for End the HIV Epidemic (EHE) initiatives. In direct response to RFA-AI-21-018, this study will use innovative technology to recruit and retain a large cohort of high-risk, HIV-negative young men who have sex with men (YMSM) focusing on racial/ethnic minority YMSM and high HIV prevalence geographic areas (known as “hot spots”). Furthermore, we will leverage this cohort to conduct a large-scale clinical trial while maintaining the standard of care control arm as a longitudinal observational cohort for epidemiologic analyses. Our study team is uniquely positioned and has all the relevant expertise to conduct this study having successfully recruited and retained more than 12,000 YMSM in a full range of research studies across the HIV continuum (e.g., epidemiology, intervention development, mHealth, PrEP, clinical trials, innovative geospatial methods). We have had specific success conducting prevention research with YMSM (17-25 years), including racially and ethnically diverse YMSM, our target demographic group. Further, we have previously leveraged advanced social media advertising techniques and used innovative geospatial analytics to target/study “communities within communities”, reaching hard-to-reach YMSM from diverse geographic areas (e.g., rural zip codes, U.S. tribal lands, etc.) and young ages (e.g., YMSM 13-18 years of age). We will harness innovative technology to recruit, during 36-months of enrollment, and then retain a large cohort (N = 5,000) of 17-25 year old YMSM, the majority being Black and Latino, who are at high-risk of HIV transmission (e.g., history of condomless anal sex) and follow them every 6 months thereafter. We will conduct an entirely virtual, digital clinical trial (Specific Aim #1) testing whether MyPEEPS Mobile (an evidence-based mHealth HIV prevention intervention) reduces HIV incidence among HIV-negative YMSM (17-25 years old) looking at the influence of theory-driven social, ecological, and geospatial factors on intervention uptake and efficacy inclusive of measures that align with traditional models of behavior change such as the Information Motivation Behavior Model. A social-ecological theoretical framework will also guide the analysis of the longitudinal observational cohort study (Specific Aim #2) of the 2,500 control arm participants to assess individual, network, geospatial, and public policy correlates of HIV risk and health seeking behaviors (e.g., PrEP uptake) comparing individuals who become HIV-positive to those who do not. Intervention Implications. The findings from this research will have important real-world implications for research and practice. For example, understanding how individual, network, geospatial, and public policy factors correlate with HIV incidence and moderate intervention effects will help inform how and where interventions should be delivered.

项目概要 迫切需要更好地了解美国艾滋病毒感染的流行病学， 特别是在顺性别同性恋、双性恋和其他男男性行为者 (MSM) 中，这是关键因素之一 结束艾滋病毒流行 (EHE) 举措所必需的人群 直接响应 RFA-AI-21-018， 这项研究将使用创新技术来招募和保留一大批高风险、艾滋病毒阴性的年轻人 男男性行为者 (YMSM) 重点关注种族/族裔少数群体 YMSM 和艾滋病毒高流行率 此外，我们将利用这个群体进行大规模的地理区域（称为“热点”）。 临床试验，同时维持护理标准对照组作为纵向观察队列 我们的研究团队具有独特的地位并拥有进行流行病学分析的所有相关专业知识。 这项研究已成功招募并保留了超过 12,000 名 YMSM 进行全方位的研究 整个 HIV 连续体的研究（例如流行病学、干预措施开发、移动医疗、PrEP、临床试验、 创新的地理空间方法）我们在 YMSM 的预防研究中取得了具体的成功。 （17-25 岁），包括种族和民族多元化的 YMSM，我们的目标人群。 以前利用先进的社交媒体广告技术并使用创新的地理空间分析 以“社区中的社区”为目标/研究，接触来自不同地理区域的难以接触到的 YMSM 地区（例如，农村邮政编码、美国部落土地等）和青少年（例如，YMSM 13-18 岁）。 利用创新技术在 36 个月的入组期间进行招募，然后留住一大批人（N = 5,000) 17-25 岁的 YMSM，其中大多数是黑人和拉丁裔，他们是艾滋病毒传播的高风险人群 （例如无安全套肛交的历史），此后每 6 个月我们将进行一次完整的调查。 虚拟、数字临床试验（具体目标 #1）测试 MyPEEPS Mobile（一种基于证据的 mHealth HIV 预防干预）可降低 HIV 阴性 YMSM（17-25 岁）的 HIV 发病率 理论驱动的社会、生态和地理空间因素对干预措施的采用和效果的影响 包括与传统行为改变模型相一致的措施，例如信息动机 社会生态理论框架也将指导纵向分析。 对 2,500 名对照组参与者进行观察性队列研究（具体目标 #2），以评估个人、网络、 地理空间和公共政策与艾滋病毒风险和寻求健康行为（例如，PrEP 的采用）的相关性比较 艾滋病毒呈阳性的人对非艾滋病毒呈阳性的人的干预影响。 研究将对研究和实践产生重要的现实影响，例如了解如何进行。 个人、网络、地理空间和公共政策因素与艾滋病毒发病率和中等程度相关 干预效果将有助于了解干预措施的实施方式和地点。