EARLY DETECTION OF IRON CARDIOMYOPATHY IN THALESSEMIA

地中海贫血铁性心肌病的早期检测

• 批准号: 7982153
• 负责人: JOHN C WOOD
• 金额: $ 4.87万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982153
• 关键词: Cardiac; Cardiology; Cardiomyopathies; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Data; Early Diagnosis; Electrocardiogram; Evaluation; Exercise; Ferritin; Funding; Grant; Holter Electrocardiography; Institution; Iron; Iron Overload; Lead; Liver; Longitudinal Studies; Magnetic Resonance Imaging; Myocardial; Patients; Performance; Prevalence; Research; Research Personnel; Resources; Rest; Source; Staging; Stress; Thalassemia; United States National Institutes of Health; heart rhythm; improved; pre-clinical

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine the relationship between cardiac function, exercise capacity, and cardiac rhythm to cardiac and liver iron loading. Eighty patients with various stages of iron overload will have a full, clinical cardiology evaluation (ECG, Echo, stress exercise and Holter monitoring) and a research MRI study (to quantify liver and myocardial iron and cardiac function). These studies may lead to 1) normative data for cardiac rhythm and performance for thalassemia patients, 2) determination of the prevalence of exercise and cardiac rhythm abnormalities in thalassemia patients with high cardiac iron and normal resting function, and 3) determination of the relationships between liver iron content, ferritin, cardiac T2* and cardiac function. These studies will provide the necessary groundwork for longitudinal studies of cardiac iron load on cardiac performance in thalassmia patients. The results of this study may lead to improved, early recognition of pre-clinical iron cardiomyopathy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是确定心脏功能，运动能力和心律与心脏和肝铁负荷之间的关系。具有各个阶段铁超负荷的80例患者将进行全面的临床心脏病学评估（ECG，ECHO，压力运动和手动监测）和研究MRI研究（量化肝脏和心肌铁和心脏功能）。这些研究可能导致1）心脏节奏和心理贫血患者的性能的规范数据，2）确定运动症患者的运动和心律异常，具有高心脏铁和正常静息功能，以及3）确定肝脏铁含量，铁蛋白，心脏T2*和Cardiac cardiac and Cardiac and rive river and静息功能。这些研究将为心脏铁负荷纵向研究丘脑患者的心脏性能提供必要的基础。这项研究的结果可能导致改善临床前心肌病的早期认识。