EXERCISE IN TYPE III GLYCOGEN STORAGE DISEASE

III 型糖原储存疾病的锻炼

• 批准号: 7950732
• 负责人: David Daniel Weinstein
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950732
• 关键词: Aldehyde-Lyases; Child; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Creatine Kinase; Enzymes; Exercise; Funding; Glycogen Storage Disease; Glycogen Storage Disease Type III; Goals; Grant; Injury; Institution; Life; Methods; Morbidity - disease rate; Muscle; Myopathy; Patients; Research; Research Personnel; Resources; Serum; Source; Testing; United States National Institutes of Health; disability; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Progressive and frequently debilitating myopathy is the major cause of morbidity in patients with type IIIa glycogen storage disease GSDIIIa. While severe disability usually does not occur until the 3rd to 4th decades of life, elevations in serum creatine kinase and aldolase concentrations often occur in young children consistent with progressive muscle damage. The elevation in muscle enzymes worsens during exercise, and restriction of exercise may decrease the progression of muscle damage. The goal of this study is to better understand the cause of exercise-related muscle injury and to test a method to prevent it.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 进行性且频繁的衰弱性肌病是 IIIa 型糖原贮积病 GSDIIIa 患者发病的主要原因。 虽然严重残疾通常要到三四十岁才会发生，但幼儿中血清肌酸激酶和醛缩酶浓度通常会升高，这与进行性肌肉损伤一致。运动期间肌酶的升高会加剧，限制运动可能会减缓肌肉损伤的进展。这项研究的目的是更好地了解运动相关肌肉损伤的原因并测试预防方法。