Training the next generation of clinical neuroscientists

培训下一代临床神经科学家

• 批准号: 10649573
• 负责人: Rene S. Kahn
• 金额: $ 42.22万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10649573
• 关键词: Clinical; Training; next generation

The last decade has witnessed a surge in new research findings in neuroscience. So far, however, that impressive progress has not translated into more effective treatments, or better outcomes, for patients with serious mental illness. Although this may just be a matter of time, another contributing factor is the lack of physician scientists in the field of clinical neuroscience. Physician scientists are uniquely capable of linking basic science findings to the clinical phenomenology of psychiatric illness. Indeed, scientists like these - with both clinical and research training - are uniquely poised to bridge the gap between basic neurobiology and clinical disease. This combination is critical for advancing our understanding of the neurobiology of psychiatric disorders - and for developing the highly needed disease-modifying treatments for psychiatric illnesses. One of the explanations for the lack of clinician-scientists is the difficulty in obtaining grant funding right after residency. This proposal aims to fill that gap. In a two-three year fellowship we will provide intense research training for a select group of psychiatrists (or PhD psychologists). Upon completion, trainees should be able to apply successfully for individual grants and develop into independent clinical neuroscientists. We aim to create clinician-researchers who can combine clinical knowledge with superior research skills. The long-term goal is to help shape the new generation of leaders in clinical neuroscience. Drs. Kahn, Malaspina and New are each renowned physician scientists who combine clinical expertise with deep research and training experience. This program will fill an important gap in the otherwise impressive translational research program at the Icahn School of Medicine at Mount Sinai (ISMMS), recognized as a top ten innovative research engine worldwide by Nature. Indeed, the Departments of Neuroscience and Psychiatry are ranked #1 and #6 respectively in NIH funding. We already have extensive experience, and a successful track record, in supporting other research career pathways, including a Physician-Scientist residency research track for MD, PhD trainees, and the first Combined Psychiatry Residency and PhD Training program in the US, funded by an NIMH R25 grant, of which Dr. New is PI. We also have 6 K awardees and 2 K99/R00 investigators in our rich training programs. The proposed T32 fellowship program is designed to train psychiatrists and clinical PhDs to formulate original research questions on etiology, pathogenesis, course, treatment and prevention of serious mental illness. Its focus is on patients with schizophrenia and major mood disorders. Each trainee, paired with a mentor, will formulate a career development plan with targeted goals for acquisition of skills, presentations, publications, gathering pilot data, and preparation of proposals for external funding - usually a career development award. Regular meetings, internally and with an external advisory board, will monitor trainee development in relevant milestones. We aim to help fill the dearth in clinical neuroscientists so that the recent advances in neuroscience can be translated into better care for the millions of patients with serious mental illness.

过去十年见证了神经科学新研究成果的激增。然而到目前为止， 对于患有此病的患者来说，令人印象深刻的进展并没有转化为更有效的治疗或更好的结果 严重的精神疾病。尽管这可能只是时间问题，但另一个影响因素是缺乏 临床神经科学领域的医师科学家。医师科学家具有独特的能力将 精神疾病临床现象学的基础科学发现。事实上，科学家们喜欢这些—— 临床和研究培训 - 具有独特的优势，可以弥合基础神经生物学和神经生物学之间的差距 临床疾病。这种组合对于增进​​我们对精神病学神经生物学的理解至关重要 疾病 - 以及开发急需的精神疾病缓解疗法。 缺乏临床医生科学家的原因之一是难以立即获得资助 居住权。该提案旨在填补这一空白。在为期两年的研究金中，我们将提供深入的研究 为选定的一组精神病学家（或心理学家博士）提供培训。完成后，学员应该能够 成功申请个人资助并发展成为独立的临床神经科学家。我们旨在创造 能够将临床知识与卓越研究技能相结合的临床医生兼研究人员。长期目标是 帮助塑造临床神经科学的新一代领导者。博士。卡恩、马拉斯皮纳和纽分别是 著名的医师科学家将临床专业知识与深厚的研究和培训经验相结合。 该项目将填补伊坎研究所令人印象深刻的转化研究项目的一个重要空白 西奈山医学院 (ISMMS) 被评为全球十大创新研究引擎 自然。事实上，神经科学系和精神病学系在 NIH 中分别排名第一和第六 资金。我们在支持其他研究方面已经拥有丰富的经验和成功的记录 职业道路，包括医学博士、博士生的医师-科学家住院医师研究轨道，以及第一个 美国精神病学住院医师培训和博士培训联合项目，由 NIMH R25 拨款资助，其中 New 博士是 PI。我们丰富的培训项目中还拥有 6 K 获奖者和 2 名 K99/R00 研究者。 拟议的 T32 奖学金计划旨在培训精神病学家和临床博士制定原创的 研究严重精神疾病的病因、发病机制、病程、治疗和预防问题。它是 重点是精神分裂症和严重情绪障碍患者。每位学员都会与一位导师配对 制定职业发展计划，以获取技能、演讲、出版物、 收集试点数据，并准备外部资金提案——通常是职业发展奖。 内部和外部咨询委员会的定期会议将监测学员在相关领域的发展情况 里程碑。我们的目标是帮助填补临床神经科学家的短缺，以便最新的进展 神经科学可以转化为对数百万患有严重精神疾病的患者提供更好的护理。

项目成果

Advanced paternal age and risk of schizophrenia in offspring - Review of epidemiological findings and potential mechanisms.

高龄父亲和后代患精神分裂症的风险 - 流行病学发现和潜在机制的回顾。

• 发表时间: 2021-07
• 影响因子: 4.5
• 作者: Khachadourian, Vahe;Zaks, Nina;Lin, Emma;Reichenberg, Abraham;Janecka, Magdalena
• 通讯作者: Janecka, Magdalena

A pull to be close: The differentiating effects of oxytocin and grief stimulus type on approach behavior in complicated grief.

接近的拉力：催产素和悲伤刺激类型对复杂悲伤中接近行为的差异化作用。

• 发表时间: 2023-09
• 作者: Arizmendi, Brian J;Seeley, Saren H;Allen, John J B;Killgore, William D S;Andrews;Weihs, Karen;O'Connor, Mary
• 通讯作者: O'Connor, Mary

Predictors of internalized mental health stigma in a help-seeking sample of youth: The roles of psychosis-spectrum symptoms and family functioning.

寻求帮助的青少年样本中内化心理健康耻辱的预测因素：精神病谱系症状和家庭功能的作用。

• 发表时间: 2021-08
• 影响因子: 4.6
• 作者: DeLuca, Joseph S;Akouri;Jay, Samantha Y;Redman, Samantha L;Petti, Emily;Lucksted, Alicia;Rouhakhtar, Pamela Rakhshan;Klaunig, Mallory J;Edwards, Sarah M;Reeves, Gloria M;Schiffman, Jason
• 通讯作者: Schiffman, Jason

An integrative study of the microbiome gut-brain-axis and hippocampal inflammation in psychosis: Persistent effects from mode of birth.

精神病中微生物组肠脑轴和海马炎症的综合研究：出生方式的持续影响。

• 发表时间: 2022-09
• 影响因子: 4.5
• 作者: Joe, Peter;Clemente, Jose C;Piras, Enrica;Wallach, David S;Robinson;Boka, Emeka;Remsen, Brooke;Bonner, Mharisi;Kimhy, David;Goetz, Deborah;Hoffman, Kevin;Lee, Jakleen;Ruby, Eugene;Fendrich, Sarah;Gonen, Oded;Malaspina, Dolores
• 通讯作者: Malaspina, Dolores

Accelerated Global and Local Brain Aging Differentiate Cognitively Impaired From Cognitively Spared Patients With Schizophrenia.

加速的整体和局部大脑老化将认知障碍患者与认知功能正常的精神分裂症患者区分开来。

• 发表时间: 2022
• 作者: Haas, Shalaila S;Ge, Ruiyang;Sanford, Nicole;Modabbernia, Amirhossein;Reichenberg, Abraham;Whalley, Heather C;Kahn, René S;Frangou, Sophia
• 通讯作者: Frangou, Sophia