Remote Intravascular Pressure Sensing using Ultrasound

使用超声波进行远程血管内压力传感

基本信息

批准号：
10648240
负责人：
Kenneth Hoyt
金额：
$ 18.66万
依托单位：
UNIVERSITY OF TEXAS DALLAS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10648240
关键词：
Animal Model Ascites Blood Pressure Blood Vessels Blood flow Calibration Catheters Cirrhosis Clinical Complication Computer software Contrast Media Creativeness Custom Data Detection Development Diagnosis Ensure Esophageal Varix Exhibits Feedback Frequencies Gases Generations Goals Hepatic Hepatic Encephalopathy Hepatorenal Syndrome Human body Hydrostatic Pressure Imaging Techniques Liquid substance Liver Liver Cirrhosis Liver diseases Maps Measurement Measures Methods Microbubbles Monitor Morbidity - disease rate Patient Care Patients Phase Transition Physical condensation Physiologic pulse Portal Hypertension Positioning Attribute Procedures Process Production Protocols documentation Research Research Project Grants Risk Reduction Signal Transduction Software Engineering System Techniques Technology Time Tissues Transducers Ultrasonic Therapy Ultrasonography Vascularization Venous Pressure level Visualization attenuation clinical translation clinically significant contrast enhanced cost design experience hepatic vein image reconstruction imaging modality imaging system improved in vitro testing in vivo in vivo evaluation innovation innovative technologies mortality nanoDroplet next generation novel phase change pressure sensor technology success transmission process ultrasound

项目摘要

PROJECT SUMMARY Many of the clinically significant complications of liver cirrhosis arise as a consequence of increased portal hypertension. Direct measurement of portal venous pressures is invasive and requires significant procedural experience. Therefore, an accurate and noninvasive method for measurement of portal venous pressure has the potential to reduce risk and enable clinicians to improve the routine workup of patients with liver disease. To that end, our group has exciting data that suggests remote pressure sensing in tissue can be performed using a novel contrast agent and custom technology we have termed tissue intravascular pressure estimation using ultrasound (TIPE-US). A recent advance was in the development of a phase-change contrast agent (PCCA), which is a stabilized liquid nanodroplet under ambient conditions but can be selectively activated using pulsed ultrasound energy to undergo a phase transition into a highly echogenic microbubble detectable using ultrasound imaging. Several studies by our group have consistently shown that the ultrasound energy required for PCCA activation is highly linear and dependent on the hydrostatic pressure of the surrounding fluid. Therefore, we hypothesize that these PCCAs and real-time ultrasound imaging techniques can be used for remote intravascular pressure sensing and detection of portal hypertension. The overarching goal of the proposed research project is to develop a next-generation TIPE-US imaging system and method for remote pressure sensing in vascularized tissue. The first aim of this project is to implement new TIPE-US functionality and feedback control on a programmable ultrasound scanner. In the second aim, we will evaluate the use of custom and monodisperse PCCAs to maximize sensing signal generation and quantification during TIPE-US imaging. We will also conduct the first in vivo tests of TIPE-US using an established animal model portal hypertension.

项目概要肝硬化的许多临床上显着的并发症是由于门脉增加而引起的。高血压。门静脉压的直接测量是侵入性的，需要大量的程序经验。因此，一种准确、无创的门静脉压测量方法具有重要意义。降低风险并使临床医生能够改善肝病患者的常规检查的潜力。对此最后，我们的团队拥有令人兴奋的数据，表明可以使用新型造影剂和定制技术我们称之为组织血管内压力估计超声（TIPE-US）。最近的进展是相变造影剂（PCCA）的开发，它是环境条件下稳定的液体纳米液滴，但可以使用脉冲选择性激活超声波能量发生相变，形成可使用超声波检测到的高回声微泡成像。我们小组的几项研究一致表明，PCCA 所需的超声能量激活是高度线性的，并且取决于周围流体的静水压力。因此，我们假设这些 PCCA 和实时超声成像技术可用于远程血管内检查门脉高压的压力传感和检测。拟议研究项目的总体目标是开发下一代 TIPE-US 成像系统和方法，用于血管化中的远程压力传感组织。该项目的首要目标是实现新的 TIPE-US 功能和反馈控制可编程超声波扫描仪。在第二个目标中，我们将评估定制和单分散的使用 PCCA 可在 TIPE-US 成像期间最大限度地提高传感信号的生成和量化。我们还将进行使用已建立的门静脉高压动物模型进行 TIPE-US 的首次体内测试。