Multiparametric ultrasound imaging for early detection of nonalcoholic fatty liver disease

多参数超声成像用于早期检测非酒精性脂肪肝

基本信息

批准号：
10320337
负责人：
Kenneth Hoyt
金额：
$ 40.17万
依托单位：
UNIVERSITY OF TEXAS DALLAS
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-21 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10320337
关键词：
Address Affect Basic Science Benign Biological Markers Blood flow Caring Cicatrix Cirrhosis Clinical Coupling Data Development Diagnosis Discrimination Disease Disease Progression Drug Industry Early Diagnosis Fatty acid glycerol esters Fibrosis Goals Hepatocyte Histologic Human Image Imaging technology Inflammation Lead Life Life Style Modification Link Lipids Liver Liver Fibrosis Liver diseases Lobular Measurement Measures Medical Methods Modeling Monitor Obesity Epidemic Pathology Patients Pattern Performance Perfusion Pharmaceutical Preparations Pharmacology Pharmacotherapy Prevalence Primary carcinoma of the liver cells Rattus Research Research Project Grants Research Proposals Risk Sampling Errors Savings Severities Staging Surrogate Markers Symptoms System Technology Testing Tissues Ultrasonography United States Validation Viscosity base biophysical model chronic liver disease clinical implementation clinically translatable comorbidity contrast enhanced cost cost effective data modeling diet and exercise disease diagnosis drug candidate elastography imaging biomarker imaging system in vivo innovation liver biopsy liver imaging liver inflammation liver transplantation non-alcoholic fatty liver disease nonalcoholic steatohepatitis rapid growth simple steatosis ultrasound virtual

项目摘要

PROJECT SUMMARY Liver disease is increasing in numbers and relevance across the globe. This disease causes no noticeable symptoms in many cases. After diagnosis, the costs associated with medical care are very high. Patients can be characterized on the nonalcoholic fatty liver disease (NAFLD) spectrum based on the progressive presence of steatosis (i.e. abnormal accumulation of fat within the liver), inflammation, ballooning, and then hepatic fibrosis. Despite the rapid growth and prevalence, the only therapy to treat NAFLD are lifestyle modifications, such as diet and exercise. While the pharmaceutical industry is actively pursuing the discovery and development of candidate drug therapies to address this unmet medical need, there is an urgent clinical need for the ability to noninvasively detect, accurately stage, and reliably monitor NAFLD. To that end, the goal of this research project is to develop a system and method for multiparametric ultrasound (mpUS) imaging of nonalcoholic fatty liver disease (NAFLD) including early pathology progression. Our preliminary findings strongly suggest that a single mpUS test that combines steatosis, ballooning, and inflammation information has the potential to provide a comprehensive estimation of the main components of early stage NAFLD. The main innovation of the proposed research project lies in the implicit link between biophysical models of NAFLD with these coordinated mpUS measurements. The first objective of this project is to develop an integrated ultrasound system and method for performing mpUS imaging. Then we will optimize this new imaging system in healthy rat liver. Lastly, we will evaluate mpUS imaging with a rat model of NAFLD that mirrors disease progression in humans. Here we will also optimize a biophysical model and longitudinal performance in the decision of NAFLD progression. If successful, this research will introduce and validate a safe, cost-effective mpUS imaging technology that can noninvasively detect, accurately stage, and reliably monitor NAFLD.

项目概要全球范围内，肝病的数量和相关性都在增加。这种疾病没有引起明显的许多情况下都会出现症状。确诊后，医疗费用非常高。患者可以非酒精性脂肪肝 (NAFLD) 谱的特征是基于进行性存在脂肪变性（即肝脏内脂肪异常堆积）、炎症、膨胀，然后是肝纤维化。尽管 NAFLD 增长迅速且流行，但治疗 NAFLD 的唯一疗法是改变生活方式，例如饮食和运动。虽然制药行业正在积极探索和开发为了解决这一未满足的医疗需求的候选药物疗法，临床迫切需要能够非侵入性检测、准确分期和可靠监测 NAFLD。为此，本研究项目的目标开发一种用于非酒精性脂肪肝多参数超声（mpUS）成像的系统和方法疾病（NAFLD），包括早期病理进展。我们的初步研究结果强烈表明，单一 mpUS 测试结合了脂肪变性、气球样变和炎症信息，有可能提供综合评估早期NAFLD的主要成分。提出的主要创新点研究项目在于 NAFLD 的生物物理模型与这些协调的 mpUS 之间的隐含联系测量。该项目的第一个目标是开发一种集成超声系统和方法进行 mpUS 成像。然后我们将在健康大鼠肝脏中优化这种新的成像系统。最后，我们将使用反映人类疾病进展的 NAFLD 大鼠模型评估 mpUS 成像。在这里我们将还优化了 NAFLD 进展决策中的生物物理模型和纵向性能。如果如果成功，这项研究将引入并验证一种安全、经济高效的 mpUS 成像技术，该技术可以非侵入性检测、准确分期和可靠监测 NAFLD。