Development

发展

• 批准号: 7746362
• 负责人: Peter M Howley
• 金额: $ 164.76万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7746362
• 关键词: Accounting; Address; Admission activity; Area; Award; Back; Body Burden; Budgets; Business Rules; Cancer Center; Cancer Center Support Grant; Categories; Charge; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Communication; Conduct Clinical Trials; Confidentiality of Patient Information; Consultations; Core Facility; Dana-Farber Cancer Institute; Data; Databases; Development; Development Plans; Diagnostic; Dimensions; Discipline; Disease; Evaluation; Faculty; Fostering; Freezing; Funding; Funding Category; Generic Drugs; Grant; Guidelines; Hospitals; Human; Image; Image Analysis; Indium; Information Networks; Intranet; Link; Liquid substance; MRI Scans; Malignant Neoplasms; Measurement; Methods; Metric; Minority; Mission; Nature; Nodal; Online Systems; Operative Surgical Procedures; Paraffin; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patients; Peer Review; Personal Computers; Pilot Projects; Play; Positron-Emission Tomography; Process; Protocols documentation; Recommendation; Recruitment Activity; Reporting; Research; Research Activity; Research Ethics Committees; Research Infrastructure; Research Personnel; Resources; Role; Route; Sampling; Scanning; Secure; Seeds; Services; Specimen; Staging; Technology; Time; Tissue Banking; Tissue Banks; Tissues; Translational Research; Tumor Bank; Tumor Volume; Underrepresented Minority; Work; anticancer research; base; clinical care; cost; data management; demographics; longitudinal database; meetings; member; new technology; patient privacy; programs; quality assurance; research facility; response; tumor; virtual; web site; working group

All Developmental Funds within DF/HCC are dispersed by the PI in consultation with the Executive Committee, based on recommendations from internal peer review as described below. We propose to use Developmental Funds in five categories: (1) Recruitment of new investigators who are either minority faculty candidates or whose research focus is "Disparities in Cancer"; (2) Pilot Projects that promote the formation of new nodal point collaborations; (3) Pilot Projects that promote the capturing of emerging scientific opportunities; (4) Timely Special Opportunity Awards; and (5) development of new Core Facilities. In year one, we request $850,000 in Developmental Funds. This is down slightly from the $1 M provided in year 5 of the current CCSG budget. The request increases to $1.3 M in the second year, for the reasons explained below, and remains at that level throughout. Minority/Disparities Investigator Recruitment. A high priority use of Developmental Funds within the Center is the recruitment of under-represented minority faculty candidates in cancer research or faculty candidates whose research focus is in the area of "Disparities in Cancer". We request $100,000 per year to supplement the start-up packages for these new recruits. Pilot Projects: New Nodal Awards. We request funds to continue a DF/HCC pilot project program aimed at promoting new translational research. These funds will be used to support new projects that foster nodal points, research involving collaborations between investigators from Disease-based and from Discipline-based Programs. Promoting translational science is the central element in the research mission of the Center, and we propose that Developmental Funds be used to support it, in part, by having open, peer-reviewed competitions among DF/HCC members engaged in emerging nodal point collaborations, as described below. Applications will be encouraged in the area of "Disparities in Cancer", and at least one of the New Nodal Awards funded each year will be restricted to this area. Each funded project would receive $75,000 per year for two years. We propose that four new projects would be funded each year. Since the funding period is two years, this would result in an increase in the second year budget of $300,000. Pilot Projects: New Opportunity Awards. We request funds to. continue a pilot project program within the Center to promote new, cancer-related seed projects that represent rich opportunities but have not yet reached nodal point status within the Center. These awards would be made on the basis of an open, peer-reviewed competition among DF/HCC members. Each project to be funded would receive $50,000 per year for two years, and three new projects would be funded each year. Since the funding period is two years, this would result in an increase in the second year budget of $150,000. Timely Special Opportunity Awards. Funds are requested to provide Program Leaders or Core Directors with small awards for urgent scientific needs of a time-sensitive nature. Applications for these awards can be submitted at any time and would be awarded as described below. Six awards (limited to a maximum of $10,000 each) would be made.each year. New Core Facilities. One of the most important benefits of Cancer Center membership is access to shared research facilities. We request Developmental Funds to support the development of new, ideally, cutting-edge technology-based Core Facilities. We request $120,000 per year for each of two new Cores in development. The $120,000 per year is requested to provide funds to manage the direct day to day activities of the developing facility. No new Core Facility would receive more than two years of designated Developmental Funds' support, but would transition after that time to support from charge-backs or from other categories of funds within the Center.

DF/HCC内的所有发展基金都由PI与执行官协商分散 委员会根据内部同行评审的建议，如下所述。我们建议 在五个类别中使用发展基金：（1）招募新调查人员 少数派候选人或研究重点是“癌症差异”； （2）试点项目 促进新的节点合作的形成； （3）促进捕获的试点项目 新兴的科学机会； （4）及时的特别机会奖； （5）开发新的 核心设施。在第一年，我们要求提供85万美元的发展基金。这略有下降 当前CCSG预算的5年级提供的$ 1 m。该请求增加到$ 1.3 m 第二年，出于下面解释的原因，并且整个水平都保持在该水平。 少数民族/差异研究者招聘。高度优先使用发展基金 中心是招募癌症研究或教职员工中代表性不足的少数群体候选人 研究重点是“癌症差异”领域的候选人。我们要求$ 100,000 一年来补充这些新兵的启动套餐。 试点项目：新节点奖。我们要求资金继续进行DF/HCC试点项目计划 旨在促进新的翻译研究。这些资金将用于支持新项目 寄养节点，研究涉及基于疾病和的研究人员之间的合作 来自基于学科的程序。促进转化科学是研究的核心要素 该中心的使命，我们建议使用发展资金来部分支持它 开放，经过同行评审的DF/HCC成员参与新兴节点的比赛 合作，如下所述。将鼓励申请在“差异 癌症”，每年资助的新的Nodal奖项中的至少一个将仅限于这一领域。 每个资助的项目将在两年内每年获得75,000美元。我们建议四个新项目 每年都会资助。由于资金期是两年，这将导致增加 第二年预算为300,000美元。 试点项目：新机会奖。我们要求资金。继续进行试点项目计划 促进新的，与癌症相关的种子项目的中心，这些项目代表丰富的机会，但没有 然而，在中心内达到了节点点状态。这些奖项将根据 DF/HCC成员之间的开放，同行评审的竞争。每个要资助的项目都将收到 每年两年的$ 50,000，每年将为三个新项目提供资金。自资助以来 周期为两年，这将导致第二年预算增加15万美元。 及时的特别机会奖。要求资金提供计划领导者或核心 具有小奖项的董事，以应对时间敏感的紧急科学需求。这些申请 奖项可以随时提交，并将如下所述授予。六个奖项（仅限于 每年最多可赚取10,000美元）。 新的核心设施。癌症中心成员资格的最重要好处之一是进入 共享研究设施。我们要求开发资金以支持新的发展， 理想情况下，最先进的基于技术的核心设施。我们每年要求$ 120,000 开发中的新核心。每年要求$ 120,000提供资金来管理直接 开发设施的日常活动。没有新的核心设施将超过两年 指定的发展基金的支持，但在此之后会过渡以支持 收费或来自中心内其他类别的资金。