Animal Biohazard Core

动物生物危害核心

• 批准号: 7812074
• 负责人: John R. Chan
• 金额: $ 21.77万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7812074
• 关键词: Acquired Immunodeficiency Syndrome; Animal Experimentation; Animal Experiments; Animal Model; Animals; Arts; Biohazardous Substance; Biology; Collaborations; Communicable Diseases; Containment of Biohazards; Data; Development; Disease; Environment; Epidemic; Equipment; Evaluation; Fostering; Funding; Goals; HIV; HIV Infections; Host Defense; Human Resources; Individual; Infection; Infectious Agent; Laboratories; Medical center; Medicine; Morbidity - disease rate; Mouse Strains; Mus; Opportunistic Infections; Organism; Pathogenesis; Performance; Persons; Play; Public Health; Research; Research Personnel; Resources; Role; Structure; Training Support; Wages; animal facility; antimicrobial; base; career development; college; cost; design; in vivo; in vivo Model; interest; investigator training; mortality; mouse model; pathogen; programs; research study; vaccine candidate

The HIV epidemic continues to pose a major threat to public health. The immunodeficient state caused by HIV infection renders the host highly susceptible to opportunistic pathogens, the latter a major cause of morbidity and mortality in individuals with AIDS. The Albert Einstein College of Medicine (AECOM) provides a rich environment for investigators to conduct HIV and AEDS-related opportunistic pathogens. In vivo animal modeling is essential to research on the pathogenesis, host defense, and treatment of pathogens. Thus, the Biohazard Animal Core, a state-ofthe- art, well-staffed facility that strives to provide a safe, efficient, and cost-effective environment for animal experimentation involving HIV and AIDS-related pathogens, is a critical component of the overall CFAR program. The major goal of the Animal Biohazard Core is to provide CFAR investigators with the technical support and training necessary for successful conduction of bio-hazardous infectious diseases mouse models. As a central program, the Biohazard Animal Core should function to foster sharing of institutional facilities and resources, stimulate scientific exchanges and collaboration, and support career development of young investigators interested in HIV-related research. Based on the progress made in the last funding period, and with AECOM institutional support, as evident by addition of new biohazard containment laboratory space, equipment, as well as salary support for Core personnel, we believe the Biohazard Animal Facility has been successful in executing such functions. We anticipate the CFAR Animal Core to continue to play an important role in facilitating HIV and opportunistic pathogen research at Einstein.

艾滋病毒的流行继续对公共卫生构成重大威胁。由HIV引起的免疫缺陷态 感染使宿主高度容易受到机会性病原体的影响，后者是发病率和 艾滋病个人的死亡率。阿尔伯特·爱因斯坦医学院（AECOM）提供了丰富的环境 为了使研究人员进行HIV和与AEDS相关的机会病原体。体内动物建模对于 关于病原体的发病机理，宿主防御和治疗的研究。因此，生物危害动物核心，一种最先进的 艺术，人工良好的设施，致力于为动物提供安全，高效且具有成本效益的环境 涉及HIV和与艾滋病相关病原体的实验是整体CFAR计划的关键组成部分。这 动物生物危害核心的主要目标是为CFAR调查人员提供技术支持和培训 成功传导生物危害性传染病小鼠模型所必需的。作为中央计划， 生物危害动物核心应起作用以促进机构设施和资源的共享，刺激科学 交流和协作，并支持对与HIV相关研究感兴趣的年轻调查人员的职业发展。 根据最后一个资金期间的进展，并在AECOM机构支持下，可以通过添加 新的Biohazard遏制实验室空间，设备以及对核心人员的薪水支持，我们相信 生物危害动物设施已成功执行此类功能。我们预计CFAR动物核心 继续在爱因斯坦促进艾滋病毒和机会性病原体研究中发挥重要作用。