ADCC Genomic Medicine Approach to MCI and Dementia

ADCC 基因组医学方法治疗 MCI 和痴呆症

• 批准号: 7647086
• 负责人: KATHLEEN Anne WELSH-BOHMER
• 金额: $ 180.35万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7647086
• 关键词: ADCC; Genomic; Medicine; Approach; MCI

DESCRIPTION (provided by applicant): This is a new ADCC submission for the Joseph and Kathleen Bryan Alzheimer's Disease Research Center (Bryan ADRC) at Duke University Medical Center. The Bryan ADRC is a multidisciplinary research center established in 1985 which supports and conducts basic science and clinical research in Alzheimer's disease (AD) and related disorders with an emphasis on genetic predisposition, early diagnosis, autopsy confirmation, and educational outreach. Efforts include special focus on the inclusion of minority populations, specifically African-Americans and an emphasis on methodological synergy between our clinic-based and population-based studies. Overall specific aims are to: (1) provide expertise for the diagnosis, prevention, and treatment of mild cognitive disorders and their transition to dementia; (2) provide the structure and context for the ascertainment, evaluation, longitudinal follow-up and research participation of large MCI and AD patient samples and multiplex genetic families; (3) disseminate tissue and provide needed resources for research; (4) facilitate clinical and basic science research of AD and related disorders, leading to advances in the biology of AD with a particular emphasis on genomic approaches (genetics, translational studies, proteomics, metabolomics, etc). The Center's structure consists of four Cores along with a privately supported Genomics Core facilitated by new collaborations with the Institute of Genomic Sciences and Policy at Duke (IGSP) and Glaxo Smith Kline. The Cores include: Clinical; Data Management & Statistics; Neuropathology; and Education; along with two pilot projects per year (determined yearly). The Center integrates, coordinates, and fosters interdisciplinary collaborations at Duke and beyond. The Bryan ADRC provides important resources, e.g., well-characterized patients and control subjects, family information, tissue and biological specimens for the new genomic medicine initiatives. The public health significance brought to bear by the Bryan ADRC with its tremendous new links to technological resources in industry is an efficient, productive, and fully collaborative structure leading to the discovery of the cause(s) of AD and related illnesses with an ultimate goal of developing scientifically well-informed, rational, and effective approaches to the prevention, care, and treatment of memory disorders and overall improvement of health care delivery.

描述（由申请人提供）：这是杜克大学医学中心约瑟夫和凯瑟琳·布莱恩阿尔茨海默病研究中心 (Bryan ADRC) 向 ADCC 提交的新文件。布莱恩 ADRC 是一个多学科研究中心，成立于 1985 年，支持并开展阿尔茨海默病 (AD) 及相关疾病的基础科学和临床研究，重点是遗传易感性、早期诊断、尸检确认和教育推广。我们所做的努力包括特别关注少数民族人口，特别是非裔美国人的纳入，以及强调我们基于临床的研究和基于人群的研究之间的方法学协同作用。总体具体目标是：（1）为轻度认知障碍及其向痴呆的转变提供诊断、预防和治疗的专业知识； (2) 为大型 MCI 和 AD 患者样本和多重遗传家族的确定、评估、纵向随访和研究参与提供结构和背景； (3) 传播组织并提供研究所需的资源； (4) 促进 AD 及相关疾病的临床和基础科学研究，推动 AD 生物学的进步，特别强调基因组方法（遗传学、转化研究、蛋白质组学、代谢组学等）。该中心的结构由四个核心以及一个私人支持的基因组核心组成，该核心由与杜克大学基因组科学与政策研究所 (IGSP) 和葛兰素史克公司的新合作推动。核心包括：临床； 数据管理与统计； 神经病理学；和教育；每年还有两个试点项目（每年确定）。该中心整合、协调和促进杜克大学及其他地区的跨学科合作。布莱恩 ADRC 为新的基因组医学计划提供重要资源，例如特征明确的患者和对照受试者、家庭信息、组织和生物标本。布莱恩 ADRC 与工业技术资源建立了巨大的新联系，对公共卫生具有重要意义，它是一个高效、富有成效和充分协作的结构，旨在发现 AD 和相关疾病的原因，并最终实现目标制定科学、合理、有效的方法来预防、护理和治疗记忆障碍，并全面改善医疗保健服务。