ALZHEIMER'S DISEASE RESEARCH CENTER

阿尔茨海默病研究中心

• 批准号: 6755123
• 负责人: KATHLEEN Anne WELSH-BOHMER
• 金额: $ 209.46万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6755123
• 关键词: Alzheimer' s disease; apolipoproteins; protein isoforms

This is the third renewal of the Joseph and Kathleen Bryan Alzheimer's Disease Research Center (Bryan ADRC) at Duke University Medical Center. The Bryan ADRC is a multi-disciplinary research center that supports and conducts basic science and clinical research in Alzheimer's disease (AD) and related disorders with an emphasis on genetic predisposition, early diagnosis, autopsy confirmation, and educational outreach. Efforts include specific aims of the Bryan ADRC are to: (1) provide expertise for the diagnosis, prevention, and treatment of dementing illnesses; (2) provide the structure and context for the ascertainment, evaluation, longitudinal follow-up and research participation of large AD families; (3) disseminate tissue and provide needed resources for research; (4) facilitate clinical research studies in AD and related disorders, and (5) perform research leading to advances in the biology of AD. The Center's structure consist of Cores: Administrative; -Clinical Research Development; Neuropathology; Education and Information Research Training; and research projects; - ApoE Maintains Blood Brain Barrier Integrity, -Cholesterol Effects on Human ApoE and APP Interactions, Oxidative Stress in AD; and two pilot projects per year (determined yearly). The Center integrates coordinates, and foster interdisciplinary collaborations of established and developing investigators. It provides important resources, e.g., well- characterized patients and control subjects, family information, tissue and biological specimens. These resources strengthen independent and collaborative research efforts, increase illnesses. The ultimate goals to be obtained are the development of prevention, care, and treatment strategies for disease victims and their families and the overall improvement of health care delivery.

这是杜克大学医学中心的约瑟夫和凯瑟琳·布莱恩·阿尔茨海默氏病研究中心（Bryan ADRC）的第三个续约。 Bryan ADRC是一个多学科研究中心，在阿尔茨海默氏病（AD）和相关疾病中支持并进行基础科学和临床研究，重点是遗传倾向，早期诊断，尸检确认和教育外展。努力包括Bryan ADRC的特定目标是：（1）为诊断，预防和治疗痴呆疾病提供专业知识； （2）提供了大型AD家族的确定，评估，纵向随访和研究参与的结构和背景； （3）传播组织并提供所需的研究资源； （4）促进AD和相关疾病的临床研究，（5）进行研究，从而在AD生物学方面取得进步。中心的结构包括核心：行政； - 临床研究开发；神经病理学；教育和信息研究培训；和研究项目； - APOE保持血脑屏障的完整性， - 胆固醇对人APOE和APP相互作用的影响，AD中的氧化应激；以及每年两个试点项目（每年确定）。该中心整合了坐标，并促进了已建立和正在发展的研究人员的跨学科合作。它提供重要的资源，例如，特征良好的患者和对照对象，家庭信息，组织和生物标本。这些资源加强了独立和协作的研究工作，增加了疾病。要获得的最终目标是针对疾病受害者及其家人的预防，护理和治疗策略的制定以及医疗保健提供的整体改善。

项目成果

Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study.

• DOI: 10.1038/s41386-021-01097-0
• 发表时间: 2021-11
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Biernacka JM;Coombes BJ;Batzler A;Ho AM;Geske JR;Frank J;Hodgkinson C;Skime M;Colby C;Zillich L;Pozsonyiova S;Ho MF;Kiefer F;Rietschel M;Weinshilboum R;O'Malley SS;Mann K;Anton R;Goldman D;Karpyak VM
• 通讯作者: Karpyak VM