CLINICAL RESEARCH SKILLS DEVELOPMENT

临床研究技能发展

基本信息

批准号：
7750504
负责人：
Augustine M Choi
金额：
$ 12.71万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7750504
关键词：
Address Basic Science Bioinformatics Chronic Obstructive Airway Disease Clinical Clinical Investigator Clinical Medicine Clinical Research Clinical Skills Communication Critical Care Databases Development Diagnosis Diagnostic Diagnostic tests Disease Disease Progression Drug toxicity Education Educational Curriculum Educational process of instructing Enrollment Ensure Environment Evolution Faculty Fostering Funding Future Genes Genetic Genetic Polymorphism Genomics Growth Guidelines Hand Health Health Services Research Healthcare Heterogeneity Human Human Genome Hypersensitivity Internal Medicine Intervention K-Series Research Career Programs Laboratories Lung Lung diseases Measurement Medicine Mentors Modality Molecular Nature Outcome Outcome Measure Pathogenesis Patient Care Pharmaceutical Preparations Physicians Physiological Postdoctoral Fellow Reporting Research Research Methodology Research Personnel Research Training Resources Scientist Stream Structure System Technology Testing Therapeutic Toxic effect Training Training Programs Translating Translational Research United States National Institutes of Health Universities Vocabulary Work base career combinatorial cost design disease classification experience functional genomics human disease interdisciplinary approach knowledge base meetings novel diagnostics programs response skills tool

项目摘要

The successful sequencing of the human genome, and the evolution of human health services research, has produced an era of unprecedented growth in the knowledge base of the molecular and physiological basis of human diseases. The abundance of high throughput genetic and genomic technologies and the rapid spread of information dictated by exponential increase in computing power and communication technology are transforming the practice of clinical medicine and clinical research. The recently developed NIH Roadmap makes clear the importance of clinical research and addresses the ways in which clinical research needs to be transformed to keep pace with laboratory, genetic, and especially genomic research and to ensure that findings are tested and effectively translated into improvements in health and health care. The main objective of this Clinical Research Skills Development Core (CRSDC) is to provide a structured, intensive research experience for physicians, physician-scientists, or scientists trainees to foster the development of skills needed to pursue a successful career in investigative clinical research in the study of chronic obstructive lung disease (COPD). We will utilize a multidisciplinary approach, focusing on the functional genomics of human COPD. CRSDC described here addresses this challenge by providing an integrated training program for junior investigators. In keeping within the guidelines of this Core, we will include trainees at postdoctoral fellow or junior faculty up to their K award training period. The CRSDC has the following specific aims: Specific Aim 1: To offer a core curriculum that integrates clinical research skills with hands-on genomics and bioinformatics training using existing programs at the University of Pittsburgh. Specific Aim 2: To develop a cross-disciplinary mentoring system that will allow junior investigators to develop their research skills and to become independent and productive clinical investigators.

人类基因组的成功测序以及人类卫生服务研究的发展已有在分子和生理基础的知识库中产生了一个前所未有的增长时代人类疾病。高吞吐量遗传和基因组技术以及快速通过计算能力和通信技术指数级增加的信息传播正在改变临床医学和临床研究的实践。最近开发的NIH 路线图清楚地表明了临床研究的重要性，并解决了临床研究的方式需要转换以与实验室，遗传学，尤其是基因组研究以及确保对发现进行测试并有效地转化为健康和卫生保健的改进。这这种临床研究技能发展核心（CRSDC）的主要目标是提供结构化的，医师，医师科学家或科学家学员的密集研究经验，以促进在研究研究中，需要开发成功从事调查临床研究的事业所需的技能慢性阻塞性肺疾病（COPD）。我们将利用一种多学科的方法，重点人COPD的功能基因组学。此处描述的CRSDC通过提供初级调查人员的综合培训计划。为了遵循该核心的指南，我们将在博士后研究员或初级教师之前，还包括在K奖培训期之前。 CRSDC具有以下具体目标：特定目的1：提供将临床研究技能与动手纳入临床研究技能相结合的核心课程基因组学和生物信息学培训使用匹兹堡大学现有计划的培训。特定目标2：开发跨学科指导系统，该系统将允许初级调查人员发展他们的研究技能并成为独立和生产性临床研究人员。