Pathways to Lower Urinary Tract Symptoms Prevention in Adolescent and Adult Women.

预防青少年和成年女性降低尿路症状的途径。

• 批准号: 10455099
• 负责人: Alayne Denise Markland
• 金额: $ 25万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10455099
• 关键词: Activities of Daily Living; Address; Adolescent; Adolescent Medicine; Adult; Affect; Age; Alabama; Area; Behavior; Behavioral Medicine; Biological; Biological Markers; Biometry; Bladder; Clinical Research; Collection; Communities; Data Coordinating Center; Detection; Development; Education; Environment; Epidemiology; Evaluation; Exercise; Foundations; Future; Gait speed; Geographic Information Systems; Geriatrics; Goals; Health; Health Sciences; Health Services Research; Health education; Home environment; Human Resources; Increased frequency of micturition; Individual; Intervention; Intervention Studies; Knowledge; Life Cycle Stages; Literature; Longitudinal Studies; Longitudinal cohort study; Measures; Medical Sociology; Methodology; Modeling; Nocturia; Occupational; Pain; Participant; Pathway interactions; Personal Satisfaction; Persons; Policies; Population Heterogeneity; Prevention; Psyche structure; Public Health; Qualitative Methods; Research; Research Methodology; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Sampling; Schools; Science; Severities; Social Well-Being; Specimen; Symptoms; Testing; Time; Travel; Universities; Urethra; Urinary Incontinence; Urinary tract infection; Urination; Woman; bladder pain; clinical examination; cohort; community based participatory research; community engagement; deprivation; design; environmental stressor; epidemiology study; health disparity; improved; indexing; inflammatory marker; lower urinary tract symptoms; mHealth; mHealth self-management; member; micturition urgency; mobile application; model development; neighborhood association; neighborhood disadvantage; novel; physical state; prevent; preventive intervention; programs; protective factors; recruit; response; social; teacher; young woman

PROJECT SUMMARY/ABSTRACT Lower urinary tract symptoms (LUTS) encompass a wide range of symptoms, including urinary incontinence, urinary frequency, urgency, nocturia, bladder pain, urinary tract infections, and voiding symptoms. There is an extensive literature describing the many approaches to treatment of LUTS, but less is known about prevention. The “Prevention of Lower Urinary Tract Symptoms (PLUS) Consortium is a transdisciplinary scientific network established to expand research beyond the treatment of LUTS to promotion of bladder health and prevention of LUTS in adolescents and women across the life course. Despite many epidemiologic studies on risk factors for LUTS, little research has examined factors that promote bladder health. One key gap is in understanding of what defines healthy voiding and toileting behaviors and how these behaviors affect bladder health over time. Our overarching hypothesis is that maladaptive voiding and toileting behaviors contribute to poorer bladder health among adolescent and adult women. The primary aim of this proposal is to continue our participation as a clinical research center in PLUS and collaborate with other centers to design and conduct a longitudinal cohort study that lays the foundation for developing future prevention interventions to promote bladder health and prevent LUTS. The University of Alabama at Birmingham (UAB) team is an interdisciplinary group of investigators with collective expertise in LUTS clinical research, behavioral medicine, geriatric medicine, adolescent medicine, prevention science, public health, epidemiology, biostatistics, health disparities, and medical sociology. Our team is poised to contribute expertise on 1) design and conduct of longitudinal studies, 2) evaluation and treatment of LUTS (including clinical examination and bio-specimen collection), 3) qualitative methods, 4) recruitment and retention of diverse samples of participants with/without LUTS, and 5) community engagement. The second aim is to build on the longitudinal cohort study to examine two additional potential risk/protective factors for bladder health and LUTS that are plausible targets for future intervention studies. In addition to testing a number of other factors in the national cohort, we propose to examine 1) the role of neighborhood disadvantage in relation to voiding and toileting behaviors, using the Area Deprivation Index, and 2) the association of functional ability with voiding and toileting behaviors using gait speed and bio-markers of inflammation. Understanding the role of these factors will support the development of models for identifying at- risk individuals and groups, as well as inform education initiatives. The third aim is to develop and conduct pilot foundational studies related to promoting healthy voiding and toileting behaviors. The first study aims to understand voiding and toileting behaviors across environments among adolescents using a mobile application with geographic information system mapping. The second aims to develop a mobile health self-management educational program for promoting healthy bladder behaviors. These projects will lay the foundation for the development of future research on interventions to promote bladder health across the life course.

项目概要/摘要 下尿路症状 (LUTS) 涵盖多种症状，包括尿失禁、 尿频、尿急、夜尿、膀胱疼痛、尿路感染和排尿症状。 大量文献描述了 LUTS 的多种治疗方法，但对于预防却知之甚少。 “预防下尿路症状 (PLUS) 联盟是一个跨学科科学网络 成立的目的是将研究范围从治疗 LUTS 扩展到促进膀胱健康和预防 尽管有许多关于危险因素的流行病学研究，但青少年和女性在整个生命过程中的 LUTS 仍然存在。 对于 LUTS，很少有研究探讨促进膀胱健康的因素，其中一个关键差距在于对 LUTS 的理解。 什么定义了健康的排尿和如厕行为以及这些行为如何随着时间的推移影响膀胱健康。 我们的首要假设是，适应不良的排尿和如厕行为会导致膀胱功能较差 该提案的主要目的是继续我们的参与。 作为 PLUS 的临床研究中心，并与其他中心合作设计和进行纵向研究 队列研究为制定未来预防干预措施以促进膀胱健康奠定了基础 阿拉巴马大学伯明翰分校 (UAB) 团队是一个跨学科小组。 在 LUTS 临床研究、行为医学、老年医学、 青少年医学、预防科学、公共卫生、流行病学、生物统计学、健康差异等 我们的团队准备在以下方面贡献专业知识：1）纵向研究的设计和实施， 2）LUTS的评估和治疗（包括临床检查和生物标本采集），3）定性 方法，4) 招募和保留有/没有 LUTS 的不同参与者样本，以及 5) 社区 第二个目标是在纵向队列研究的基础上检查另外两个潜力。 膀胱健康和 LUTS 的风险/保护因素是未来干预研究的合理目标。 除了测试全国队列中的许多其他因素外，我们建议检查 1） 使用面积剥夺指数，了解邻里在排尿和如厕行为方面的劣势，以及 2) 使用步态速度和生物标记将功能能力与排尿和如厕行为关联起来 了解这些因素的作用将支持开发用于识别炎症的模型。 第三个目标是制定和实施教育举措。 与促进健康排尿和如厕行为相关的试点基础研究第一项研究旨在 使用移动应用程序的青少年在不同环境中的排尿和如厕行为 第二个目标是开发移动健康自我管理系统。 这些项目将为促进健康膀胱行为奠定基础。 发展未来干预措施的研究，以促进整个生命过程中的膀胱健康。