FOCUSED ULTRASOUND CORE

聚焦超声核心

• 批准号: 7960867
• 负责人: Nathan J. McDannold
• 金额: $ 98.3万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960867
• 关键词: Automobile Driving; Computer Retrieval of Information on Scientific Projects Database; Devices; Electronics; Focused Ultrasound Therapy; Funding; Grant; Image; Institution; Location; Mechanics; Phase; Positioning Attribute; Research; Research Personnel; Resources; Shapes; Signal Transduction; Sonication; Source; System; Thermal Ablation Therapy; Tissues; Transducers; Ultrasonic wave; Ultrasonography; United States National Institutes of Health; image guided therapy; two-dimensional

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of this proposal is to take an advantage of two dimensional ultrasound phased arrays for image guided thermal ablation. Two dimensional phased arrays offer several advantages over single focused transducers. First, in an array, the location of the focus is controlled by an electronic signal so it is not necessary to physically move the applicator with a mechanical positioning device to shift the focal location. This ability allows fast focusing, making it possible to track moving targets. It also minimizes the space requirements for the sonication system and allows one to rapidly move the focus and to generate multiple foci simultaneously. Second, the shape of the ultrasound field is controlled by the driving signals, thus allowing departure from a sharp, elongated focus. This feature makes it possible to enlarge the coagulated volume per sonication and to optimize the focal shape for each treatment and even for each sonication during a treatment. Finally, with a phased array applicator, distortions to the ultrasound wave induced by the overlying tissues can be compensated for using imaging information of the wave propagation path.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该提案的总体目的是利用图像引导的热消融的二维超声阵列。二维分阶段阵列比单个集中的传感器具有多个优点。首先，在数组中，焦点的位置由电子信号控制，因此无需用机械定位设备将涂药器物理移动以移动焦点位置。这种功能可以快速聚焦，从而可以跟踪移动目标。它还可以最大程度地减少超声处理系统的空间要求，并允许人们快速移动焦点并同时生成多个焦点。其次，超声场的形状由驾驶信号控制，从而使远距离伸长的焦点偏离。此功能使得可以扩大每次超声处理的凝结体积，并在治疗过程中优化每种处理的焦点形状，甚至可以优化每种超声处理。最后，使用一个分阶段的阵列涂抹器，可以通过使用波传播路径的成像信息来补偿对上覆组织引起的超声波的扭曲。