Human Microbiome and its Role in the Development of Lumbar Spine Degeneration and Modic Changes

人体微生物组及其在腰椎退变和现代变化发展中的作用

• 批准号: 10453349
• 负责人: Dino Samartzis
• 金额: $ 17.37万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10453349
• 关键词: Address; Affect; Age; Alzheimer' s Disease; Applications Grants; Bacteria; Biological Markers; Blood; Blood Vessels; Bone Marrow; Chronic; Chronic low back pain; Collection; Degenerative Disorder; Development; Diabetes Mellitus; Diffusion; Disease; Etiology; Feces; Future; Genomics; Health Care Costs; Heterogeneity; Human Microbiome; Image; Immune; Individual; Infection; Infiltration; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Intervention; Intervertebral disc structure; Intestines; Kidney; Knowledge; Lead; Lesion; Low Back Pain; Magnetic Resonance Imaging; Metabolic; Methods; Microbe; Microbiology; Nature; Nutrient; Operative Surgical Procedures; Outcome; Oxygen; Pain; Pathologic; Patients; Phenotype; Population; Process; Psychological Stress; Research; Risk Factors; Role; Route; Sampling; Severities; Site; Skin; Spinal; Spine surgery; Sterility; Stress; Structure; Study Subject; Techniques; Time; Tissues; United States; Vertebral column; Wages; Work; age related; base; biomarker discovery; case control; cost effective measures; gut microbiome; gut microbiota; human disease; human subject; inflammatory marker; intervertebral disk degeneration; metabolomics; microbial community; microbiome; microbiome research; microbiota profiles; microorganism; novel; pain patient; skin microbiota; spine bone structure; subchondral bone; systemic inflammatory response; targeted treatment

Summary Chronic low back pain (LBP) is the world’s most disabling condition, whose management outcomes are often unsatisfactory and health-care costs worldwide are astronomical. Modic changes Type 1 (MC1: subchondral bone marrow lesions adjacent to the endplate that are associated with inflammation) on magnetic resonance imaging (MRI) are highly associated with the development and severity of chronic LBP. The etiology of MC1 remains speculative. Systemic inflammatory and metabolomic biomarkers have been associated with MCI; however, still under scrutiny. Intervertebral disc degeneration (DD) in general has been associated with bacterial invasion, but not replicated and questionable. The human microbiome has been associated with a string of human diseases. The following proposal aims to identify if lumbar MC1 are associated with the pro-inflammatory nature of the intestinal microbiome compared to non-MC1 intervertebral discs. Integrative approaches taking into account the microbiome, metabolomics and systemic inflammatory markers will also be addressed in relation to MCI of the lumbar spine.

概括 慢性腰痛 (LBP) 是世界上最严重的致残性疾病，其治疗方法 莫迪奇的治疗结果往往不尽如人意，全世界的医疗保健费用也是天文数字。 1 型改变（MC1：邻近终板的软骨下骨髓病变， 磁共振成像 (MRI) 上的炎症与炎症密切相关 慢性 LBP 的发展和严重程度 MC1 的病因仍然是推测性的。 然而，全身炎症和代谢组生物标志物与 MCI 相关； 椎间盘退变（DD）总体上仍与相关。 细菌入侵，但人类微生物组尚未复制且值得怀疑。 以下建议旨在确定腰椎是否与一系列人类疾病相关。 与肠道微生物组相比，MC1 与肠道微生物组的促炎性质相关 非 MC1 椎间盘。考虑到微生物组的综合方法， 代谢组学和全身炎症标志物也将与 MCI 相关 腰椎。