Influence of moderate hearing loss on auditory perception & cortical processing

中度听力损失对听觉感知的影响

• 批准号: 7784304
• 负责人: Dan Harvey Sanes
• 金额: $ 32.2万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7784304
• 关键词: ARHGEF5 gene; Acoustics; Address; Adolescence; Adolescent; Adult; Affect; Animals; Auditory; Auditory Perception; Auditory area; Behavior; Behavioral; Brain; Child; Code; Communication; Conductive hearing loss; Control Animal; Cues; Data; Data Analyses; Detection; Development; Frequencies; Gerbils; Goals; Hearing; Human; Individual; Laboratories; Language Development; Lead; Measurable; Measures; Metric; Nervous System Physiology; Neuraxis; Neurons; Operant Conditioning; Pattern; Perception; Performance; Process; Property; Proteinase 3; Sensorineural Hearing Loss; Sensory; Shapes; Signal Transduction; Stimulus; Structure; Synaptic Membranes; Testing; Time; Training; Work; awake; base; ear infection; early experience; experience; hearing impairment; improved; juvenile animal; middle ear; neurodevelopment; public health relevance; relating to nervous system; response; skills; sound; theories

DESCRIPTION (provided by applicant): Many auditory perceptual skills mature over a long time course (in humans), well into the teenage years. If hearing is disrupted during development, there may be long-lasting deficits in auditory perception and language acquisition. Surprisingly, maturation of the auditory coding properties that support late-emerging perceptual skills are largely unknown; what little we do know is based solely on recordings from anesthetized animals. This is also why our understanding of the effect of mild to moderate hearing loss on central auditory maturation is unsettled. To address these issues, I will examine functional development in awake animals for the first time, and explore how auditory coding properties are influenced by sensory experience. The central hypothesis is that moderate hearing loss during development disrupts coding properties in the auditory cortex (ACx), leading to measurable deficits in auditory perceptual performance. There are three related aims: AIM 1 will determine whether developmental conductive hearing loss disrupts the perceptual abilities of adult gerbils. Animals will be tested on two tasks that, in humans, are known to have different rates of maturation and to be affected by hearing loss. These include detection of sinusoidal amplitude (sAM) and frequency modulated (sFM) signals. AIM 2 will determine whether training on an auditory task during juvenile development can rescue normal perceptual behavior in animals reared with conductive hearing loss. AIM 3 will characterize the normal rate of development of neural coding properties underlying the percepts examined in Aim 1, and will assess whether these coding properties are perturbed in a manner that correlates with perceptual deficits examined in AIM 1. Single unit recordings will be obtained from the ACx of awake animals during the period of development that follows cochlear maturation. The broad goals are to determine whether coding properties mature at different rates, as suggested by behavioral studies, and to determine whether sAM or sFM coding is vulnerable to early hearing loss. Together, these data will provide the first analysis of auditory coding in awake developing animals, and reveal whether moderate hearing loss disrupts both perceptual skills and the coding properties that support them. PUBLIC HEALTH RELEVANCE: Profound hearing loss in children can produce long-lasting deficits in auditory perception and language acquisition, and it has been suggested that mild to moderate hearing loss, including that commonly associated with middle ear infections, might also impact auditory performance. To address this question, we will induce conductive hearing loss in developing animals, and study their behavioral performance and central auditory nervous system function as adults. Thus, this study will examine whether moderate hearing loss disrupts both perceptual skills and the neural coding properties that support them.

描述（由申请人提供）：许多听觉感知技能在长期（在人类中）成熟，直到少年时代。如果听力在开发过程中受到干扰，则听觉感知和语言获取可能会有持久的赤字。令人惊讶的是，支持晚期感知技能的听觉编码属性的成熟是未知的。我们所知道的仅基于麻醉动物的录音。这也是为什么我们对轻度至中度听力损失对中央听觉成熟的影响的理解尚未解决。为了解决这些问题，我将首次研究清醒动物的功能发展，并探讨听觉编码属性如何受感官体验的影响。中心假设是，开发过程中的中等听力损失破坏了听觉皮层（ACX）中的编码特性，从而导致听觉感知性能的可测量缺陷。有三个相关的目的：AIM 1将决定发育导电性听力损失是否会破坏成年球鼠的感知能力。将对动物进行两项任务进行测试，在人类中，众所周知，成熟率不同，并受到听力损失的影响。这些包括检测正弦幅度（SAM）和频率调制（SFM）信号。 AIM 2将确定在少年发育过程中对听觉任务的培训是否可以挽救因导电性听力损失而饲养的动物的正常感知行为。 AIM 3将表征AIM 1中检查感知的神经编码特性的正常发育速率，并将评估这些编码特性是否以与AIM 1中检查的感知缺陷相关的方式扰动。在COCHEAL成熟的开发期间，将从ACX的ACX中获得单位记录。广泛的目标是确定行为研究所暗示的编码属性是否以不同的速度成熟，并确定SAM或SFM编码是否容易受到早期听力损失的影响。这些数据将共同提供对醒着的动物中听觉编码的首次分析，并揭示中等听力损失是否会破坏感知技能和支持它们的编码属性。 公共卫生相关性：儿童的巨大听力损失可能会导致听觉感知和语言获取的持久赤字，并且有人建议轻度至中度的听力损失（包括通常与中耳感染相关的听力损失）也可能影响听觉表现。为了解决这个问题，我们将引起发展动物的导电性听力损失，并研究其行为表现和中央听觉神经系统作为成年人的功能。因此，这项研究将检查中度听力损失是否会破坏感知技能和支持它们的神经编码属性。