Influence of moderate hearing loss on auditory perception & cortical processing

中度听力损失对听觉感知的影响

• 批准号: 8301723
• 负责人: Dan Harvey Sanes
• 金额: $ 30.78万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8301723
• 关键词: ARHGEF5 gene; Acoustics; Address; Adolescence; Adolescent; Adult; Affect; Animals; Auditory; Auditory Perception; Auditory area; Behavior; Behavioral; Brain; Child; Code; Communication; Conductive hearing loss; Control Animal; Cues; Data; Data Analyses; Detection; Development; Frequencies; Gerbils; Goals; Hearing; Human; Individual; Laboratories; Language Development; Lead; Measurable; Measures; Metric; Nervous System Physiology; Neuraxis; Neurons; Operant Conditioning; Pattern; Perception; Performance; Process; Property; Proteinase 3; ST5 gene; Sensorineural Hearing Loss; Sensory; Shapes; Signal Transduction; Stimulus; Structure; Synaptic Membranes; Testing; Time; Training; Work; awake; base; ear infection; early experience; experience; hearing impairment; improved; juvenile animal; middle ear; neurodevelopment; relating to nervous system; response; skills; sound; theories

PROJECT SUMMARY Many auditory perceptual skills mature over a long time course (in humans), well into the teenage years. If hearing is disrupted during development, there may be long-lasting deficits in auditory perception and language acquisition. Surprisingly, maturation of the auditory coding properties that support late-emerging perceptual skills are largely unknown; what little we do know is based solely on recordings from anesthetized animals. This is also why our understanding of the effect of mild to moderate hearing loss on central auditory maturation is unsettled. To address these issues, I will examine functional development in awake animals for the first time, and explore how auditory coding properties are influenced by sensory experience. The central hypothesis is that moderate hearing loss during development disrupts coding properties in the auditory cortex (ACx), leading to measurable deficits in auditory perceptual performance. There are three related aims: AIM 1 will determine whether developmental conductive hearing loss disrupts the perceptual abilities of adult gerbils. Animals will be tested on two tasks that, in humans, are known to have different rates of maturation and to be affected by hearing loss. These include detection of sinusoidal amplitude (sAM) and frequency modulated (sFM) signals. AIM 2 will determine whether training on an auditory task during juvenile development can rescue normal perceptual behavior in animals reared with conductive hearing loss. AIM 3 will characterize the normal rate of development of neural coding properties underlying the percepts examined in Aim 1, and will assess whether these coding properties are perturbed in a manner that correlates with perceptual deficits examined in AIM 1. Single unit recordings will be obtained from the ACx of awake animals during the period of development that follows cochlear maturation. The broad goals are to determine whether coding properties mature at different rates, as suggested by behavioral studies, and to determine whether sAM or sFM coding is vulnerable to early hearing loss. Together, these data will provide the first analysis of auditory coding in awake developing animals, and reveal whether moderate hearing loss disrupts both perceptual skills and the coding properties that support them.

项目摘要 在十几岁的时候，许多听觉感知技能（在人类中）都成熟。如果 听力在开发过程中受到干扰，听觉感知可能存在持久的赤字和 语言获取。出乎意料的是，支持后期出现的听觉编码属性的成熟 知觉技能在很大程度上是未知的。我们所知道的仅基于麻醉的录音 动物。这也是为什么我们对轻度至中度听力损失对中央听觉的影响的理解 成熟是不安的。为了解决这些问题，我将研究清醒动物的功能发展 第一次，并探讨听觉编码属性如何受感官体验的影响。中央 假设是，开发过程中的中等听力损失破坏了听觉皮层中的编码特性 （ACX），导致听觉感知性能的可测量缺陷。有三个相关目标：目标1 将确定发育导电性听力损失是否破坏了成年gerbils的感知能力。 在人类中，将对动物进行测试，这些任务已知成熟率不同，并且要为 受听力损失的影响。这些包括检测正弦幅度（SAM）和频率调制 （SFM）信号。 AIM 2将确定在少年开发过程中对听觉任务的培训是否可以 挽救因导电性听力损失而饲养的动物中的正常感知行为。 AIM 3将表征 AIM 1中检查的感知的基础神经编码属性的正常发展速率，并将 评估这些编码属性是否以与知觉缺陷相关的方式扰动 在AIM 1中检查。将从醒着动物的ACX获得单位记录。 遵循人工耳蜗成熟的发展。广泛的目标是确定是否编码属性 如行为研究所建议的，以不同的速度成熟，并确定SAM或SFM编码是 容易受到早期听力损失的影响。这些数据将共同提供对醒着的听觉编码的首次分析 发展动物，并揭示中等听力损失是否会破坏感知技能和编码 支持它们的属性。