Enhancing Bone Quality Assessment Using Quantitative Ultrasound

使用定量超声增强骨质量评估

• 批准号: 7699222
• 负责人: JAMES Gegan MILLER
• 金额: $ 34.48万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7699222
• 关键词: Address; Age; Bone Density; Chairperson; Communities; Detection; Diagnostic; Disease; Doctor of Medicine; Doctor of Philosophy; Drug Design; Dual-Energy X-Ray Absorptiometry; Economic Burden; Environment; Fracture; Generations; Goals; Gold; Grant; Health Care Costs; Hip region structure; Intervention; Laboratories; Masks; Measurement; Measures; Medicine; Methods; Minerals; Molecular Biology; Monitor; Osteoporosis; Paris, France; Pharmacological Treatment; Pharmacology; Phase; Physics; Population; Principal Investigator; Property; Quality of life; Research; Research Personnel; Risk; Role; Signal Transduction; Site; Techniques; Tissues; Transducers; Ultrasonics; Ultrasonography; United States Food and Drug Administration; Universities; Vertebral column; Washington; Work; base; bone; bone quality; calcaneum; college; cost; design; diagnosis standard; high risk; improved; innovation; novel strategies; osteoporosis with pathological fracture; professor; public health relevance; quantitative ultrasound; residence; transmission process

DESCRIPTION (provided by applicant): Fracture risk associated with osteoporosis represents a concern that is likely to become ever more serious as the nation's population ages. The FDA has approved 7 drugs designed to slow or reverse osteoporosis. The gold standard for monitoring pharmacological treatment is Dual Energy X-ray Absorptiometry (DEXA), which provides a measure of bone mineral density (BMD). In principle, bone sonometry is capable of providing additional information regarding bone quality because it is sensitive not only to bone mineral density but also to microstructure and orientation which influence fracture risk. In spite of its promise, however, sonometry has not yet been shown to provide such additional bone quality information, in part because of the specific limitations to be addressed in the proposed research. Phase cancellation at the receiving transducer has a negative impact on bone sonography. Transmission of ultrasound through bone is results in the generation of multiple modes of propagation including fast and slow waves, mode convertion, and multiple scattering - effects that can mask the underlying material properties of bone that determine fracture risk. At present, sonometry is limited to sites permitting through transmission such as the cancaneus, whereas sites at highest risk of fracture such as the hip would be accessible only to backscattered ultrasound. We have therefore identified three specific aims: 1) Identify, segregate, and overcome limitations of current transmission-based calcaneus sonometry arising from phase cancellation at the receiving transducer, 2) implement Bayes inversion of the ultrasonic signals to estimate the underlying bone material properties from received transmission sonometry signals complicated by the presence of multiple modes, and 3) validate, expand, and refine methods for estimating fracture risk in high risk sites such as the hip based on backscattered ultrasound. The long-term goal of the proposed research is to enhance and expand bone sonometry to facilitate its role in monitoring bone quality and the potential regression of osteoporosis with the aid of pharmacological interventions. PUBLIC HEALTH RELEVANCE: Osteoporotic fractures reduce quality of life and carry enormous health care costs. Sonometry could improve bone quality assessment because, unlike DEXA, it is sensitive to bone microstructure and orientation. The proposed research addresses fundamental improvements to existing sonometry techniques, and explores new techniques applicable to the hip and spine that are at relatively high risk of fracture but currently cannot be monitored.

描述（由申请人提供）：与骨质疏松症相关的断裂风险代表了一个关注，随着国家人口年龄的增长，它可能会变得更加严重。 FDA批准了7种旨在减慢骨质疏松症的药物。监测药理学治疗的金标准是双能X射线吸收仪（DEXA），它提供了骨矿物质密度（BMD）的度量。原则上，骨骼运动能够提供有关骨质质量的其他信息，因为它不仅对骨矿物质密度敏感，而且对影响断裂风险的微观结构和方向敏感。但是，尽管有希望，但尚未证明声音学可以提供此类额外的骨质信息，部分原因是拟议的研究中需要解决的具体局限性。接收传感器的相位取消对骨骼超声检查产生负面影响。超声通过骨骼的传播是导致多种传播模式的产生，包括快速和慢速波，模式转化和多个散射 - 可以掩盖确定骨骼的基本材料的效果，从而确定骨折风险。目前，符合诸如Cancaneus之类的传输的站点仅限于允许骨折的最高风险（例如髋关节）的位置，仅用于反向散射超声。因此，我们已经确定了三个具体目的：1）确定，鉴定，隔离和克服对接收传感器时相位取消产生的基于传输的基于传输的跟骨的局限性，2）2）实施超声信号的贝叶斯倒置，以估算接收到的传输传输信号的估算，并通过多种模态估算了骨骼物质的估算，并通过多种模态估算了多种模态的估算，以及3）的估算，以及3）的范围，以及3）的范围，并估算了多种模态的范围，以及3），并估算了3）的范围，并估算了3）。高风险位点，例如基于反向散射超声波的髋关节。拟议的研究的长期目标是增强和扩展骨骼声学，以促进其在监测骨质质量和借助药理学干预措施的骨质疏松症的潜在回归中的作用。公共卫生相关性：骨质疏松性骨折降低了生活质量并承担巨大的医疗保健成本。孔径可以改善骨质量评估，因为与DEXA不同，它对骨微结构和方向敏感。拟议的研究涉及现有声学技术的基本改进，并探索适用于髋关节和脊柱的新技术，这些技术的裂缝风险相对较高，但目前无法监测。