A self-capacitance driven wearable electromyometrial imaging system for maternal and fetal monitoring during pregnancy and labor

一种自电容驱动的可穿戴式肌电成像系统，用于妊娠和分娩期间的母婴监测

• 批准号: 10445605
• 负责人: Chuan Wang
• 金额: $ 33.86万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445605
• 关键词: 3-Dimensional; Abdomen; Address; Adoption; Area; Benchmarking; Birth; Body Surface; Body of uterus; Brain; Cerebral Palsy; Child; Clinical; Clinical Research; Clinical Treatment; Data; Delivery Rooms; Electric Capacitance; Electrodes; Engineering; Fetal Monitoring; Fetal Mortality Statistics; Geometry; Gold; Health; Heart; Heart failure; Home; Human; Image; Imaging technology; Impaired cognition; Joints; Knowledge; Longitudinal cohort; Magnetic Resonance Imaging; Maps; Measurement; Measures; Medical center; Mental Retardation; Methods; Monitor; Morphologic artifacts; Motion; Organ; Outcome; Outpatients; Pathologic; Patients; Pattern; Performance; Perinatology; Persons; Pregnancy; Pregnant Women; Premature Birth; Premature Labor; Printing; Research; Research Activity; Resolution; Risk; Schedule; Signal Transduction; Site; Stretching; Surface; System; Technology; Telemetry; Transducers; Translating; United States; Universities; Uterine Contraction; Uterine Monitoring; Uterus; Validation; Visual impairment; Washington; base; clinical application; clinical translation; cost; density; design; effectiveness evaluation; electrical property; hearing impairment; human subject; imaging platform; imaging study; imaging system; improved; instrument; instrumentation; mechanical properties; member; new technology; novel; patient mobility; portability; prevent; sensor; temporal measurement; tool; treatment strategy; wireless

PROJECT SUMMARY Approximately 10% of pregnant women give birth preterm In the United States and worldwide, which not only results in a high rate of fetal mortality but also puts the children at a lifelong risk of negative health consequences such as cerebral palsy, mental retardation, and visual and hearing impairments. Despite years of research, the mechanisms of initiation and propagation of uterine contractions resulting in preterm labor and birth remain unknown. In large part, this is because of our limited ability to monitor the human uterine contractions with sufficient spatial and temporal resolutions. This leads to a lack of critical knowledge of the pathologic factors that alter the normal uterine maturation, initiate preterm labor, and result in preterm birth. In order to address this unmet clinical and research need, our team has recently developed a novel high-resolution and noninvasive electromyometrial imaging (EMMI) system, which uses up to 256 unipolar electrodes to measure uterine electrograms from the patient's abdomen surface and then combines the patient-specific body-uterus geometry obtained by magnetic resonance imaging (MRI) to generate accurate and robust three-dimensional maps of uterine electrical activity during contractions. Because such a powerful experimental tool could permit closer and more precise study of birth-related risks and improve maternal and child outcomes, we believe there could be a significant clinical impact for us to develop a low-cost, wireless, and wearable version in order to make this imaging technology more accessible for outpatient or in-home monitoring settings. We propose to develop and validate the functionality of a unique wearable EMMI system with printed disposable electrodes, wireless power delivery, and telemetry for continuously monitoring of the uterine contraction activities in ambulatory patients. The proposed research activity will involve developing of ultrathin soft sensor patches with printed stretchable electrodes for recording high quality electrograms from the patient’s abdomen and generating accurate and robust 3D maps of the uterine surface; investigating and designing a novel self-capacitance based wireless power transfer instrumentation for wirelessly powering all the sensing and telemetry circuits at each recording site in a fully distributed high-density imaging system; validating the wireless and wearable EMMI system in human subjects and benchmarking its performance against “gold standard” wired EMMI system. Upon successful completion of this study, the entirely new wearable, wireless, and batteryless imaging system developed in the project will facilitate EMMI's clinical translations, allow it to be used outside the delivery room for outpatient setting or in-home monitoring applications, and ultimately enable us to leverage the electrical mapping data for evaluating uterine electrical maturation and contraction patterns during pregnancy and labor and use the results to better understand and treat preterm birth.

项目概要 在美国和世界范围内，大约 10% 的孕妇早产，这不仅 导致胎儿死亡率很高，但也使儿童终生面临负面健康后果的风险 尽管经过多年的研究，仍发现脑瘫、智力低下、视力和听力障碍等。 导致早产和分娩的子宫收缩启动和传播的机制仍然存在 很大程度上，这是因为我们监测人类子宫收缩的能力有限。 足够的空间和时间分辨率导致缺乏对病理因素的批判性认识。 改变正常的子宫成熟度，引发早产，并导致早产。 未满足的临床和研究需求，我们的团队最近开发了一种新型的高分辨率和非侵入性 肌电成像 (EMMI) 系统，使用多达 256 个单极电极来测量子宫 来自患者腹部表面的电图，然后结合患者特定的身体子宫几何形状 通过磁共振成像 (MRI) 获得，以生成准确且稳健的三维图 因为这样一个强大的实验工具可以让我们更接近和更接近宫缩期间的子宫电活动。 更精确地研究出生相关风险并改善孕产妇和儿童结局，我们相信可能会出现 对我们开发低成本、无线和可穿戴版本的重大临床影响，以便使这一 成像技术更适合门诊或家庭监测环境。 我们建议开发并验证独特的可穿戴 EMMI 系统的功能，该系统带有印刷 一次性电极、无线供电和遥测技术，用于连续监测子宫 拟议的研究活动将涉及超薄患者的收缩活动。 带有印刷可拉伸电极的软传感器贴片，用于记录患者的高质量电图 腹部并生成准确且可靠的子宫表面 3D 地图； 新颖的基于自电容的无线功率传输仪器，用于为所有传感和 完全分布式高密度成像系统中每个记录站点的遥测电路验证无线； 和可穿戴 EMMI 系统在人类受试者中的应用，并根据“黄金标准”有线对其性能进行基准测试 EMMI 系统成功完成这项研究后，推出了全新的可穿戴、无线、无电池系统。 该项目开发的成像系统将促进 EMMI 的临床转化，使其能够在体外使用 用于门诊环境或家庭监控应用的产房，最终使我们能够利用 用于评估怀孕期间子宫电成熟和收缩模式的电测绘数据 和分娩并利用结果更好地了解和治疗早产。