Rapid Free-Breathing 3D High-Resolution MRI for Volumetric Liver Iron Quantification

用于体积肝铁定量的快速自由呼吸 3D 高分辨率 MRI

基本信息

批准号：
10742197
负责人：
Youngwook Kee
金额：
$ 17.7万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10742197
关键词：
3-Dimensional Abdomen Address Adult Adverse effects Affect Algorithms Anemia Biliary Biological Markers Blood Transfusion Body Image Breathing Cancer Patient Cardiomyopathies Cardiotoxicity Caucasians Chelating Agents Chelation Therapy Child Childhood Clinical Clinical Management Clinical Research Cone Contrast Media Data Development Diagnosis Dimensions Directories Endocrine Ethnic Origin Failure Ferritin Functional disorder Genetic Goals Growth Head Hematologic Neoplasms Hematological Disease Hemochromatosis Hemosiderosis Hepatic Hepatology Hereditary hemochromatosis Image Image Analysis Image Compression Impairment Individual Inferior Ionizing radiation Iron Iron Overload Left Liver Liver Fibrosis Macrophage Magnetic Resonance Imaging Malignant Neoplasms Measurement Methodology Methods Microscopic Modeling Monitor Morbidity - disease rate Motion Motivation Movement Not Hispanic or Latino Organ Outcome Pancreas Patients Performance Physicians Population Primary carcinoma of the liver cells Process Race Reader Relaxation Research Resolution Risk Sampling Scanning Scheme Signal Transduction Slice Sorting Speed Structure Techniques Testing Thick Time Tissues Transfusion United States Venous blood sampling Wait Time Work accurate diagnosis body system chelation chronic liver disease cluster computing data acquisition data space design efficacy evaluation experience high dimensionality image reconstruction imaging biomarker improved innovation intravenous administration iron oxide nanoparticle liver biopsy liver imaging magnetic field multidisciplinary negative affect novel pediatric patients pharmacologic quantitative imaging radiologist reconstruction research clinical testing respiratory side effect spatiotemporal standard of care superparamagnetism tissue oxygenation

项目摘要

Project Summary Motivation: In the United States, approximately 1 in 300 non-Hispanic Caucasians have hereditary hemochromatosis with varying rates in other ethnicities and races. Transfusion hemosiderosis often develops in cancer patients who have received repeated blood transfusions for cancer-related anemia treatment. Iron overload, if left untreated, can cause fatal organ damage. Treatment of iron overload aims at reducing body iron stores with phlebotomy or chelation therapy to maintain sufficiently low body iron levels while minimizing adverse effects. Liver iron concentration is widely accepted for the best indicator of total body iron stores; therefore, accurate liver iron quantification improves clinical management of iron overload and minimizes side effects of chelator administration. MRI-based R2* relaxometry (R2*-MRI) is a noninvasive clinical standard for liver iron quantification with no ionizing radiation due to its sensitivity to the presence of tissue iron. R2*-MRI acquires images at multiple time points to estimate R2* (= 1/T2*) relaxation rates at each voxel. However, clinically available R2*-MRI is prone to patient movement such as respiratory motion that breath-holding is commonly practiced during scan. Breath-holding is challenging for children and some adults, and unsatisfactory breath- holding leads to poor R2* values. The other challenge with the current R2*-MRI is caused by signal loss due to rapid T2* decay in the presence of a high concentration of iron. Severe iron loading is commonly seen in patients with transfusion-induced iron overload, and the current R2*-MRI does not reliably capture such a rapid signal decay, resulting in inaccuracy in R2* measurements. This project addresses these challenges to provide novel R2*-MRI methods for accurate and consistent liver iron quantification. Approach: The project has two development aims that are validated on clinical studies. Aim 1 will enable rapid free-breathing ultrashort TE MRI, which acquires images at multiple time points for R2* measurements. Such acquisition is achieved by incorporating a 3D center-out k-space trajectory with multiple data readouts with self- navigator without scan time overhead, facilitating parallel imaging compressed sensing. Aim 2 will enable retrospectively motion-corrected image reconstruction that makes use of a low-rank tensor structure of the acquired 3D spatiotemporal volumetric data. We will develop strategies for data parallelism and distributed computing for computationally demanding tensor-based multidimensional reconstruction. Aim 3 will determine the performance of the innovations in a clinical setting. Significance: This work will lead to rapid, robust, free-breathing abdominal MRI for more accurate assessment of liver iron overload in children and adults. The techniques will facilitate widespread application in quantitative body imaging.

项目概要动机：在美国，大约每 300 名非西班牙裔白人中就有 1 人患有遗传性疾病血色素沉着症在其他民族和种族中的发病率不同。输血含铁血黄素沉着症常发生于因癌症相关贫血治疗而反复接受输血的癌症患者。铁如果不及时治疗，超负荷可能会导致致命的器官损伤。铁过载的治疗旨在减少体内铁通过放血或螯合疗法储存，以维持足够低的体内铁水平，同时最大限度地减少不良反应影响。肝脏铁浓度被广泛认为是体内总铁储存的最佳指标；所以，准确的肝铁定量可改善铁过载的临床管理并最大限度地减少副作用螯合剂管理。基于 MRI 的 R2* 松弛测量 (R2*-MRI) 是肝铁的无创临床标准由于其对组织铁的存在敏感，因此无需电离辐射即可进行定量。 R2*-MRI 采集多个时间点的图像来估计每个体素的 R2* (= 1/T2*) 弛豫率。然而，临床上可用的 R2*-MRI 容易出现患者运动，例如屏气常见的呼吸运动扫描时练习。屏气对于儿童和一些成人来说是一项挑战，并且呼吸不满意- 持有会导致较差的 R2* 值。当前 R2*-MRI 的另一个挑战是由于以下原因造成的信号丢失：高浓度铁存在时 T2* 快速衰减。严重铁负荷常见于患者输血引起的铁过载，目前的 R2*-MRI 无法可靠地捕获如此快速的信号衰减，导致 R2* 测量不准确。该项目解决了这些挑战，提供了新颖的 R2*-MRI 方法可实现准确一致的肝脏铁定量。方法：该项目有两个经过临床研究验证的开发目标。目标 1 将实现快速自由呼吸超短 TE MRI，可在多个时间点获取图像以进行 R2* 测量。这样的采集是通过将 3D 中心向外 k 空间轨迹与多个数据读出相结合来实现的导航器没有扫描时间开销，有利于并行成像压缩感知。目标 2 将启用回顾性运动校正图像重建，利用低秩张量结构获取 3D 时空体积数据。我们将制定数据并行和分布式策略计算要求高的基于张量的多维重建。目标 3 将决定创新在临床环境中的表现。意义：这项工作将带来快速、稳健、自由呼吸的腹部 MRI，以实现更准确的评估儿童和成人肝脏铁超载。这些技术将促进定量分析的广泛应用身体成像。