Structural and Functional Characterization of a Novel Model for Glaucoma Research

青光眼研究新模型的结构和功能表征

• 批准号: 7685380
• 负责人: Gillian Jane McLellan
• 金额: $ 16.85万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685380
• 关键词: Address; Affect; Animal Model; Blindness; Breeding; Cat Diseases; Cells; Clinical; Complex; Development; Disease Progression; Doctor of Philosophy; Early Diagnosis; Electrophysiology (science); Ethics; Evaluation; Family Felidae; Felis catus; Five-Year Plans; Fluorophotometry; Foundations; Functional disorder; Glaucoma; Goals; Human; Image; Inherited; Laboratory Research; Mentorship; Modeling; Natural History; Ophthalmology; Optic Nerve; Optical Coherence Tomography; Outcome; Pathology; Pathway interactions; Patients; Physiologic Intraocular Pressure; Physiological; Population; Research; Research Personnel; Research Priority; Research Project Grants; Resolution; Resources; Retina; Retinal; Structure; Structure-Activity Relationship; Testing; Theoretical model; Therapeutic Intervention; Training; Training Programs; Translations; Ultrasonography; Veterinarians; Visual; aqueous; autosomal recessive trait; base; career; cohort; comparative; disabling disease; effective therapy; genetic pedigree; in vivo; longitudinal course; novel; optic nerve disorder; primary congenital glaucoma; programs; research study; skills; tonometry; treatment strategy

DESCRIPTION (provided by applicant): The fundamental goal of this project is to establish a hovel, spontaneous, inherited feline model for human glaucoma research. A viable breeding colony has been established and we have determined that this form of feline glaucoma is inherited as an autosomal recessive trait. This proposal outlines a five-year plan to conduct rigorous clinical, functional and morphological characterization of primary glaucoma within this pedigree of cats. Over the first 3 years of the project, a cohort of cats will be evaluated longitudinally by both non-invasive means (including tonometry, high resolution ultrasonography, fluorophotometry, optical coherence tomography and electrophysiology) and by histomorphological evaluation of retinal and optic nerve pathology, in order to characterize the natural history of disease progression and establish structure function correlations. In the final years of the project we will begin to examine the outcomes of intraocular pressure-lowering as a neuroprotective treatment strategy on disease progression in a further cohort of cats. Results of the proposed studies will provide clues as to the complex patho-physiological basis of glaucoma and will address a number of key research priorities of the NEI's research program in glaucoma and optic neuropathies. The candidate of this proposal is a veterinarian with prior clinical and PhD training in the field of comparative ophthalmology. This research project will provide a framework for a training program, under the mentorship of leading researchers in their respective fields, which will afford the candidate the opportunity to gain new laboratory research skills as well as further training in the ethical, responsible and efficient conduct of research. The proposed training program will provide the candidate with a strong background in glaucoma research and serve as the foundation for a career as an academic veterinary clinician and independent researcher. Glaucoma is an important cause of vision loss in the human population. The development of effective treatment strategies for glaucoma patients is currently hampered by a lack of accessible, well-characterized, large animal models. Once characterized, this model will represent a valuable resource for other investigators and will facilitate the translation of laboratory research findings into new clinical strategies for the early detection and more effective treatment of this disabling disease in human patients.

描述（由申请人提供）：该项目的基本目标是为人类青光眼研究建立一个简陋的、自发的、遗传性的猫科动物模型。一个可行的繁殖群体已经建立，我们已经确定这种形式的猫青光眼是作为常染色体隐性遗传的。该提案概述了一个五年计划，对该猫谱系中的原发性青光眼进行严格的临床、功能和形态学表征。在该项目的前三年，将通过非侵入性手段（包括眼压测量、高分辨率超声检查、荧光光度测量、光学相干断层扫描和电生理学）以及视网膜和视神经病理学的组织形态学评估对一组猫进行纵向评估，为了表征疾病进展的自然史并建立结构功能相关性。在该项目的最后几年，我们将开始检查降低眼压作为神经保护治疗策略对更多猫疾病进展的结果。拟议研究的结果将为了解青光眼复杂的病理生理基础提供线索 并将解决 NEI 在青光眼和视神经病变研究项目中的一些关键研究重点。该提案的候选人是一位在比较眼科领域接受过临床和博士学位培训的兽医。该研究项目将在各自领域的领先研究人员的指导下提供一个培训计划框架，这将为候选人提供获得新的实验室研究技能的机会，并在道德、负责任和高效的行为方面接受进一步的培训。研究。拟议的培训计划将为候选人提供青光眼研究方面的强大背景，并为学术兽医临床医生和独立研究员的职业生涯奠定基础。青光眼是人类视力丧失的重要原因。目前，由于缺乏易于使用、特征良好的大型动物模型，青光眼患者有效治疗策略的制定受到阻碍。一旦确定特征，该模型将为其他研究人员提供宝贵的资源，并将有助于将实验室研究结果转化为新的临床策略，以便早期检测和更有效地治疗人类患者的这种致残疾病。