Commercialization of Novel Silicon Microslit Filters for Microplastic Contamination Testing

用于微塑料污染测试的新型硅微缝过滤器的商业化

基本信息

批准号：
10325256
负责人：
James Andrew Roussie
金额：
$ 66.76万
依托单位：
SIMPORE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10325256
关键词：
Achievement Address Award Beverages Birefringence California Canada Cities Computer software Country Custom Data Detection Development Devices Environment Environmental Pollution Excision Filtration Fishes Food Fresh Water Glues Government Health Hemlock Human Injections International Intestines Label Lead Legal patent Letters Literature Mammals Maps Marketing Membrane Metals Methods Microscope Molds Oceans Particulate Pattern Peripheral Permeability Phase Pollution Polymers Positioning Attribute Price Process Production Protocols documentation Publications Publishing Research Personnel Research Project Grants Robotics Route Sampling Seawater Services Silicon Slide Small Business Innovation Research Grant Source Standardization Surveys System Technology Testing Universities Vacuum Validation Vendor Voice Water analytical tool authority base coastal water commercialization consumer product cost drinking water human tissue improved instrument nanomembrane novel pollutant pressure sensor product development scale up screening testing services time use tool validation studies water sampling water testing

项目摘要

Abstract Environmental pollution by microplastics (MPs) in fresh water and oceans is a growing problem that is now well-recognized in both the popular media and scientific literature. Concerning levels of MPs have been found in food and local waters, as well as in human tissues. Several government regulatory bodies have (or are in the process of) implementing mandatory MP drinking water testing, including the State of California, Canada, and a number of EU countries. This Phase II SBIR project addresses the need for improved tools and related services for capturing and analyzing MPs. Our precedent Phase I SBIR award established the utility of our (SiMPore's) silicon nanomembranes with micron-scale rectangular pores (“microslit filters”) for the capture and analysis of MPs. We demonstrated utility in detecting MPs in consumer beverages and throughout a spatial map of the City of Rochester (NY) water system. We created a new venture (ParVerio) commercializing MP testing services based on SiMPore's membranes. We established products' features according to voice-of-customer data, are participating in an international MP detection lab validation study, and are engaging a large instrument vendor as co-development partner for product marketing. This Phase II project will advance the manufacturing of microslit filters, automate their packaging into 13 mm discs for compatibility with existing vacuum filtration devices, and develop peripherals for rapid MP screening and filter analysis. We will scale our nanomembrane production to multi-wafer batches to reach cost-of-good targets in lined with identified pricing levels. We will develop a process for combining injection-molded 13 mm disc blanks and nanomembrane chips using pick-and-place robotics, precision glueing, and thermal curing. We will also develop two peripheral products: 1) a machined 25x75 mm footprint microscope slide to hold three 13 mm discs; and 2) a proprietary filtration apparatus with software, readouts, and transmembrane pressure sensors for rapid water sample screening. This second device will automate the identification of samples with debris and the production of optimal samples for analysis. Through subcontracts, we will support novel end-use applications at spin-out ParVerio and the University of Rochester (UR). ParVerio will develop a MP challenge test (NSF/ANSI 42 Particulate Class I Reduction standard) as a service for assessing MP removal efficiency of filtration products. At UR, the McGrath and Knox labs will develop thermal birefringence using microslit filters as a low-cost, label free approach for MP identification. The successful development of thermal birefringence would become a Parverio service and product and dramatically expand the number of end-users doing MP analysis because of low instrument costs. This Phase II project will support the commercialization of SiMPore's microslit filters to meet the expanding needs for MP capture and analysis products and related services. Our products will benefit a growing number of concerned water authorities, regulatory bodies, and researchers working to understand the scope of MP pollution and to mitigate its impacts on health and the environment.

抽象的淡水和海洋中微塑料 (MP) 造成的环境污染是一个日益严重的问题现在在大众媒体和科学文献中都得到了广泛的认可。在食品和当地水域以及多个政府监管机构中都发现了这种物质。已经（或正在）实施强制性 MP 饮用水测试，包括以下州：加利福尼亚州、加拿大和一些欧盟国家的第二阶段 SBIR 项目满足了对 SBIR 的需求。改进了用于捕获和分析 MP 的工具和相关服务。我们的先例 I 期 SBIR 奖项确立了我们（SiMPore）硅纳米膜的实用性：我们展示了用于捕获和分析 MP 的微米级矩形孔（“微缝过滤器”）。用于检测消费饮料中以及整个罗切斯特市空间地图中的 MP 的实用性（纽约）水系统。我们创建了一家新企业 (ParVerio)，将 MP 测试服务商业化。 SiMPore的膜我们根据客户的声音数据确定了产品的特点，参与国际 MP 检测实验室验证研究，并正在使用大型仪器供应商作为产品营销的共同开发合作伙伴，该第二阶段项目将推进制造微缝过滤器，将其自动包装成 13 毫米圆盘，以兼容现有的真空过滤设备，并开发用于快速 MP 筛选和过滤分析的外围设备。我们将把纳米膜生产规模扩大到多晶圆批次，以达到在线生产的良好成本目标我们将开发一种结合注塑 13 毫米圆盘的工艺。使用拾放机器人、精密粘合和热固化来制造毛坯和纳米膜芯片。还将开发两种外围产品：1) 机加工的 25x75 毫米足迹显微镜载玻片，用于固定三个 13 毫米圆盘；2) 带有软件、读数和跨膜的专有过滤装置用于快速水样筛选的压力传感器第二个设备将自动识别水样。带碎片的样品以及生产用于分析的最佳样品。通过分包合同，我们将支持衍生公司 ParVerio 和大学的新型最终用途应用程序罗切斯特 (UR) 的 ParVerio 将开发 MP 挑战测试（NSF/ANSI 42 I 类颗粒物）。降低标准）作为评估过滤产品 MP 去除效率的服务。麦格拉思和诺克斯实验室将使用微缝滤光片开发热双折射作为一种低成本、无标签的技术热双折射的成功开发将成为 MP 识别的方法。 Parverio 服务和产品，并大幅增加进行 MP 分析的最终用户数量因为仪器成本低。该二期项目将支持 SiMPore 微缝滤波器的商业化，以满足 MP 捕获和分析的需求扩大了我们的产品和相关服务。越来越多的水务主管部门、监管机构和研究人员致力于了解 MP 污染的范围并减轻其对健康和环境的影响。