FAMILY AND SOCIAL ECOLOGY MODULE

家庭和社会生态学模块

• 批准号: 7618709
• 负责人: TIMOTHY C BLACKSON
• 金额: $ 6.61万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7618709
• 关键词: Affect; Age; Alcohol or Other Drugs use; Behavior; Child; Childhood; Clinical; Complex; Conflict (Psychology); Data; Development; Disease; Disinhibition; Ecology; Environment; Etiology; Exposure to; Family; Family Relationship; Family history of; Female; Genotype; Goals; Individual; Laboratories; Mediating; Methodology; Neighborhoods; Numbers; Outcome; Persons; Phenotype; Prevention program; Probability; Progress Reports; Psychopathology; Research; Review Literature; Risk; Risk Factors; Role; Sampling; Score; Severities; Substance Use Disorder; Testing; Variant; anti social; deviant; family influence; heuristics; indexing; interest; male; neurobehavior; parental influence; peer; psychologic; social; statistics; stressor; trait

The overarching aim of the Family and Social Ecology Module (FSEM) is to prospectively elucidate the influences of family, peer and neighborhood environment, in relation to individual psychological phenotype and genotype, on the risk for substance use disorder (SLID) in early adulthood (age 19). This research module thus provides the data inputs pertaining to environment factors necessary for the Scientific Core to accomplish the three centerwide goals. The hypotheses to be tested in the FSEM in the next five years focus on the specific and conjoint impact of three environment domains (family, peers, neighborhood) on variation in individual liability (e.g., neurobehavior disinhibition) on substance use behavior and clinical SUD. Aim 1 is directed at elucidating the reciprocal influence of parenting practices and dyadic family relationships on the previously established association between parental SUD, deviant peer affiliations and child's substance use severity from ages 10-12, 12-14, 16 and 19. Aim 2 will identify the family, peer and neighborhood factors, including exposure to stressors, that moderate the relationship between neurobehavior disinhibition (ND) and level of substance use involvement across four timepoints of assessment (ages 10-12, 12-14, 16, 19). Aim 3 will delineate the factors in the environment (family, peers, neighborhood), in conjunction with ND phenotype, genotype and stressors that directly affect, mediate, or moderate the association between substance use and SUD across ages 10-12, 12-14, 16 and 19. Aim 4 is concerned with determining the role of quality of the family, peer, and neighborhood environments in the cross-generational transmissibility of substance use involvement. Thus, findings obtained from the FSEM will guide the development of contextually specific and developmentally appropriate prevention programs that effectively reduce the risk for developing SUDs.

家庭和社会生态模块 (FSEM) 的总体目标是前瞻性地阐明家庭、同伴和邻里环境与个人心理表型和基因型相关的对成年早期物质使用障碍 (SLID) 风险的影响。 19 岁）。因此，该研究模块提供了与科学核心实现三个中心目标所需的环境因素相关的数据输入。 未来五年将在 FSEM 中测试的假设侧重于三个环境领域（家庭、同侪、邻居）对个人责任变化（例如神经行为去抑制）、物质使用行为和临床 SUD 的具体和联合影响。目标 1 旨在阐明养育方式和二元家庭关系对先前建立的父母 SUD、异常同伴关系和 10-12、12-14、16 和 19 岁儿童物质使用严重程度之间关系的相互影响。目标 2 将 确定家庭、同伴和邻里因素，包括暴露于压力源，这些因素在四个评估时间点（10-12、12-14、16、19 岁）调节神经行为去抑制 (ND) 和物质使用参与程度之间的关系。目标 3 将描述环境中的因素（家庭、同龄人、邻居），以及直接影响、介导或调节 10-12 岁、12-14 岁年龄段物质使用与 SUD 之间关联的 ND 表型、基因型和压力源、16 和 19。目标 4 涉及 确定家庭、同伴和邻里环境的质量在物质使用跨代传播中的作用。因此，从 FSEM 获得的结果将指导制定具体情况和适合发育的预防计划，从而有效降低发生 SUD 的风险。