CB: Tissue Core

CB：组织核心

• 批准号: 7507435
• 负责人: Lisa Rimsza
• 金额: $ 25.46万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7507435
• 关键词: Aliquot; Applications Grants; Arizona; Blood; Bone Marrow Cells; Cancer Center; Cataloging; Catalogs; Cell Line; Cells; Clinical; Clinical Trials; Collection; Consent; Correlative Study; DNA; Data Collection; Development; Diagnostic; Ensure; Equipment and supply inventories; Evaluation; Feasibility Studies; Freezing; Funding; Goals; Guidelines; Health Insurance Portability and Accountability Act; Hematopathology; Immunophenotyping; Informed Consent; Institution; Laboratories; Lymphoid Cell; Lymphoid Tissue; Lymphoma; Lymphoproliferative Disorders; Malignant - descriptor; Molecular; Paraffin; Pathologic; Patients; Procedures; Process; Protocols documentation; RNA; Reproduction spores; Research Ethics Committees; Research Personnel; Research Project Grants; Resources; Sampling; Serum; Specimen; Suspension substance; Suspensions; Testing; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Universities; Work; abstracting; career; interest; programs; repository; software development; tissue resource

COREB: SPECIMEN The combined Tissue Resource Core at the Universities of Arizona and Rochester will have the responsibility of collecting, storing and cataloging pathological specimens from patients with lymphoproliferative disorders that are seen at the Arizona and James P Wilmot Cancer Centers at the Universities of Arizona and Rochester respectively. In addition, the Core will also collect and store normal lymphoid tissue and blood and bone marrow cells to be used as controls for biologic studies that use the corresponding malignant tissue. Specimens are stored as snap frozen blocks, paraffin blocks, viable cell suspensions, and frozen serum aliquots. Tissue procurement and data collection is done under the auspices of IRB approved protocols at each institution. All patients are required to sign an informed consent before abstracting clinical or epidemiologic information using procedures that maintain strict patient anonymity and that adhere to the guidelines established by the Health Insurance Portability and Accountability Act (HIPAA). In addition, at U of A, excess diagnostic tissue from non-consented patients is stored as a matter of routine practice. No clinical information is abstracted on these patients without direct IRB approval and waiver of informed consent. However, these tissues are more frequent and make valuable samples for test development and feasibility studies. A bank of hematolymphoid cell lines is also maintained with active collection of new cell lines of interest. These facilities are already integrated with each other regarding sample distribution and software development. The overall goal of the Tissue Resource Core is to provide necessary patient samples and cell lines to support the Lymphoma SPORE translational research projects. The specific aims are: 1. To consent, collect, store, and annotate high quality samples in accordance with regulatory guidelines in order to maximize their potential usefulness; 2. To characterize samples through pathologic evaluation, immunophenotyping, molecular studies, and clinical features; 3. To conserve tissues through careful inventory control, creation of tissue microarrays, up-front extraction of DMA and RNA; 4. To distribute samples in a timely and efficient manner to maximize their translational research potential. These combined resources at the University of Arizona and Rochester will be intimately involved with each of the projects proposed in this SPORE grant application and will facilitate the development of collaborative projects within and beyond the SPORE.

核心：标本 亚利桑那大学和罗切斯特大学的联合组织资源核心将拥有 收集，存储和分类病理标本的责任 在亚利桑那州和詹姆斯·P·威尔莫特癌症中心看到的淋巴增生性疾病 亚利桑那大学和罗切斯特大学。此外，核心还将收集和存储正常 淋巴组织，血液和骨髓细胞用作使用使用该的生物学研究的对照 相应的恶性组织。样品被存储为快照冷冻块，石蜡块，可行的细胞 悬浮液和冷冻血清等分试样。组织采购和数据收集是在主持下完成的 IRB批准的每个机构的协议。所有患者都必须在之前签署知情同意书 使用维持严格患者匿名性和的程序来抽象临床或流行病学信息 遵守《健康保险可移植性和问责制法》（HIPAA）制定的准则。 此外，在A的U中，非持续患者的过量诊断组织被定期存储 实践。未经直接IRB批准并放弃了这些患者的临床信息。 知情同意。但是，这些组织更频繁，并制作有价值的样品进行测试 发展和可行性研究。还可以维持一系列血小结构性细胞系 收集新的感兴趣细胞线。这些设施已经相互整合 样本分布和软件开发。组织资源核心的总体目标是提供 必要的患者样品和细胞系以支持淋巴瘤孢子转化研究项目。 具体目的是： 1。根据监管指南，同意，收集，存储和注释高质量样本 为了最大程度地提高其潜在有用性； 2。通过病理评估，免疫表型，分子研究和 临床特征； 3。通过仔细的库存控制来保护组织，创建组织微阵列，前期提取 DMA和RNA； 4。及时有效地分发样品以最大程度地发挥其翻译研究潜力。 亚利桑那大学和罗切斯特大学的这些合并资源将与每个人密切参与 在本孢子赠款应用程序中提出的项目中，将促进协作的发展 孢子内外的项目。