Somatosensory stimulation therapies for movement disorders

体感刺激疗法治疗运动障碍

• 批准号: 10311109
• 负责人: Dawn Marie Taylor
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311109
• 关键词: Area; Back; Brain; Chemical Exposure; Chronic; Clinical; Cutaneous; Deep Brain Stimulation; Disease; Dopamine; Effectiveness; Electrodes; Exhibits; Feedback; Frequencies; Future; General Population; Goals; Grant; Hindlimb; Human; Implant; Incidence; Limb structure; Modeling; Monitor; Motor; Motor Activity; Movement Disorders; Muscle; Neurodegenerative Disorders; Neurons; Neurotoxins; Operative Surgical Procedures; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Pathologic; Pathology; Pathway interactions; Patients; Pattern; Performance; Peripheral; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Phase; Physiologic pulse; Production; Randomized; Rattus; Records; Risk; Sensory; Signal Transduction; Skin; Somatosensory Receptor; Symptoms; Synapses; Technology; Testing; Therapeutic; Time; Tremor; Veterans; Work; brain surgery; combat; design; excitotoxicity; experience; improved; military veteran; minimally invasive; motor symptom; neural circuit; neural implant; novel; phase change; receptor; relating to nervous system; response; sensory input; side effect; somatosensory; subcutaneous; symptom management; symptomatic improvement

The goal of this project is to develop better ways to treat motor symptoms of Parkinson’s disease. People with Parkinson’s disease typically have higher amounts of synchronization across sensorimotor brain areas especially in the beta bands. This abnormal synchrony is thought to impede the production of normal motor patterns. Breaking up that excess synchrony can potentially improve motor symptoms and may help to renormalize brain network functioning. To that end, somatosensory stimulation will be used in a rat model of Parkinson’s disease to try to disrupt the excess brain network synchrony seen in Parkinson’s disease. Motor improvements and brain network changes will be directly compared when stimulation is used to activate two types of somatosensory receptors: 1) proprioceptive receptors (via electrically induced twitches in limb muscles), and 2) cutaneous receptors (via subcutaneous stimulation to activate the cutaneous receptors directly). Additionally, two types of stimulation patterns will also be compared: 1) a consistent desynchronizing pattern, and 2) a randomly varying pattern. Motor activity will be quantified before, during and after each combination of stimulation options. The stimulation option that improves motor performance the most will then be further assessed to determine whether it’s best to continuously apply that type of stimulation (open loop) or to only turn it on when the brain is exhibiting excess synchrony (closed loop). The results of this study will guide future human testing and could provide a less risky, non- or minimally invasive treatment option with fewer side effects than current stimulation options like deep brain stimulation.

该项目的目标是开发更好的方法来治疗帕金森氏症的运动症状 患有帕金森病的人通常具有更高的同步程度。 整个感觉运动大脑区域，尤其是β带，这种异常的同步性是存在的。 被认为会阻碍正常运动模式的产生。 可以潜在地改善运动症状，并可能有助于重新正常化大脑网络功能。 为此，将在帕金森病大鼠模型中使用体感刺激来尝试 破坏帕金森病运动中出现的过度大脑网络同步。 当使用刺激时，将直接比较改善和大脑网络变化 激活两种类型的体感受体：1）本体感觉受体（通过电 诱发肢体肌肉抽搐），以及 2）皮肤受体（通过皮下刺激 直接激活皮肤受体）此外，还将有两种类型的刺激模式。 可以比较：1) 一致的去同步模式，以及 2) 随机变化的模式。 在每种刺激选项组合之前、期间和之后的活动都将被量化。 然后将进一步评估最能提高运动表现的刺激选项 确定是否最好连续施加该类型的刺激（开环）或仅施加该类型的刺激 当大脑表现出过度同步（闭环）时打开它。 将指导未来的人体测试，并可以提供风险较小、无创或微创的方法 与目前的深部脑刺激方案相比，副作用更少的治疗方案 刺激。