Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)

匹兹堡艾滋病毒共病调查和治疗指导培训 (HIV MeTrICC)

• 批准号: 9764161
• 负责人: John W Mellors
• 金额: $ 41.25万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9764161
• 关键词: Acquired Immunodeficiency Syndrome; Africa; Applications Grants; Area; Basic Science; Blood; Blood Vessels; Chronic; Clinical; Clinical Research; Cohort Studies; Comorbidity; Development Plans; District of Columbia; Doctor of Philosophy; Drug Kinetics; Ensure; Faculty; Fostering; Funding; Generations; Goals; Grant; HIV; HIV Infections; Heart; Individual; Inflammation; International; Investigation; Lung; Manuscripts; Maryland; Measures; Mentors; Morbidity - disease rate; Postdoctoral Fellow; Preparation; Research; Research Methodology; Research Personnel; Research Project Grants; Research Proposals; Research Training; Secure; Site; Sleep; Technology; The Multicenter AIDS Cohort Study; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vocational Guidance; Women’s Interagency HIV Study; Writing; antiretroviral therapy; base; career; career development; cohort; experience; inner city; mortality; multidisciplinary; programs; recruit; skills; success; training opportunity

ABSTRACT: Chronic sequelae of long-term HIV infection and treatment including heart, lung, blood, and sleep (HLBS) co-morbidities are increasingly important causes of morbidity and mortality. Latent HIV and maladaptive inflammation also persist despite successful ART. Therefore, we propose a new training program in HIV-related research, the Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC), led by Drs. Alison Morris, Dr. John Mellors, and Solomon Ofori-Acquah. They have an outstanding training record for PhDs and MDs, and their research experience spans the spectrum from basic to translational to clinical with expertise in lung, blood, and vascular co-morbidities and HIV cure. HIV MeTrICC will be an interdisciplinary, intensive mentored research training and career development experience focused around two interrelated training tracks – HLBS Co-morbidities and HIV Cure with the following objectives: 1) To provide intensive mentoring in HIV-associated HLBS Co-morbidities and HIV Cure. Our team of established Mentors will offer unique multidisciplinary mentoring and career guidance to Scholars in the conduct of HIV research projects. Scholars will choose Mentors from the MeTrICC Co-morbidities and HIV Cure tracks. Tracks will be highly interactive. 2) To provide didactic training to foster progression to an independent career in HIV-related research. Formal training will encompass a broad spectrum of research methodologies, technologies, and analytical approaches to basic, clinical, and translational HIV research. Scholars with varying levels of prior research experience will be supported by Individual Development Plans geared to their needs. 3) To provide opportunities for training in Inner-city HIV and International HIV settings. Scholars will be able to choose from two different focus areas if relevant to their career plan. For the Inner-city HIV focus, we partner with the University of Maryland and the NIH to provide experience with the District of Columbia Partnership for AIDS Progress, the nation’s largest urban HIV cohort study. For our International HIV focus, we utilize several sites in Africa with ongoing basic, clinical, and translational research. 4) To provide access to large, multi-center HIV studies: Scholars will have access to large cohort studies including the Multicenter AIDS Cohort Study, the Women’s Interagency HIV Study, the Strategic Timing of Antiretroviral Therapy pulmonary substudy, the Pittsburgh HIV Lung Research Cohort, and the Pharmacokinetic and Clinical Observations in People over 50 sleep Substudy. 5) To support scholars in preparation of an independent research proposal: The program will ensure that Scholars rapidly develop grant-writing skills and submit competitive grant applications to help them secure HIV research funding. We will support five post-doctoral Scholars (MDs and PhDs) for a period of 2 to 3 years based on initial level of experience (i.e. post-docs vs junior faculty). The success of the MeTrICC program will be measured by concrete milestones such first author manuscripts, grant funding, and transition to faculty with the ultimate goal to recruit a new generation of researchers to HIV and HLBS complications.

摘要：长期感染艾滋病毒的慢性后遗症及治疗，包括心、肺、血液和睡眠 (HLBS) 合并症日益成为发病和死亡的重要原因。 尽管抗逆转录病毒疗法取得了成功，但炎症仍然持续存在。因此，我们提出了一项新的艾滋病毒相关培训计划。 匹兹堡艾滋病毒共病调查和治疗指导培训 (HIV MeTrICC) 领导的研究 作者：Alison Morris 博士、John Mellors 博士和 Solomon Ofori-Acquah 他们拥有出色的培训记录。 博士和医学博士，他们的研究经验涵盖从基础到转化到临床的范围 MeTrICC 在肺、血液和血管并发症以及 HIV 治疗方面的专业知识将是一个跨学科的、 集中指导的研究培训和职业发展经验集中在两个相互关联的领域 培训课程 – HLBS 合并症和 HIV 治疗，目标如下： 1) 提供强化培训 我们的导师团队将提供 HIV 相关 HLBS 合并症和 HIV 治疗方面的指导。 为开展艾滋病毒研究项目的学者提供独特的多学科指导和职业指导。 学者们将从 MeTrICC 共病和艾滋病毒治疗轨道中选择导师。 2) 提供教学培训，以促进艾滋病毒相关领域的独立职业发展。 正式培训将涵盖广泛的研究方法、技术和知识。 具有不同水平先前水平的艾滋病毒基础、临床和转化研究的分析方法。 研究经验将得到适合其需求的个人发展计划的支持 3) 提供。 学者们可以选择在市中心艾滋病毒和国际艾滋病毒环境中接受培训的机会。 来自两个不同的重点领域（如果与他们的职业计划相关） 对于内城艾滋病毒重点，我们与 马里兰大学和美国国立卫生研究院将与哥伦比亚特区艾滋病合作伙伴关系提供经验 Progress，全国最大的城市艾滋病毒队列研究，为了我们的国际艾滋病毒重点研究，我们利用了以下几个地点。 非洲正在进行基础、临床和转化研究 4) 提供大规模、多中心艾滋病毒的获取。 研究：学者们将有机会参与大型队列研究，包括多中心艾滋病队列研究、 妇女机构间艾滋病毒研究、抗逆转录病毒治疗肺部亚研究的战略时机、 匹兹堡 HIV 肺研究队列，以及 50 岁以上人群的药代动力学和临床观察 睡眠子研究 5) 支持学者准备独立研究提案：该计划 将确保学者快速发展资助写作技能并提交有竞争力的资助申请以帮助 他们获得艾滋病毒研究经费。我们将在一段时间内支持五名博士后学者（医学博士和博士）。 根据初始经验水平（即博士后与初级教师），需要 2 至 3 年 MeTrICC 的成功。 计划将通过具体的里程碑来衡量，例如第一作者手稿、赠款资金以及向 教师的最终目标是招募新一代研究艾滋病毒和 HLBS 并发症的研究人员。