Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)

匹兹堡艾滋病毒共病调查和治疗指导培训 (HIV MeTrICC)

• 批准号: 9764161
• 负责人: John W Mellors
• 金额: $ 41.25万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9764161
• 关键词: Acquired Immunodeficiency Syndrome; Africa; Applications Grants; Area; Basic Science; Blood; Blood Vessels; Chronic; Clinical; Clinical Research; Cohort Studies; Comorbidity; Development Plans; District of Columbia; Doctor of Philosophy; Drug Kinetics; Ensure; Faculty; Fostering; Funding; Generations; Goals; Grant; HIV; HIV Infections; Heart; Individual; Inflammation; International; Investigation; Lung; Manuscripts; Maryland; Measures; Mentors; Morbidity - disease rate; Postdoctoral Fellow; Preparation; Research; Research Methodology; Research Personnel; Research Project Grants; Research Proposals; Research Training; Secure; Site; Sleep; Technology; The Multicenter AIDS Cohort Study; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vocational Guidance; Women’s Interagency HIV Study; Writing; antiretroviral therapy; base; career; career development; cohort; experience; inner city; mortality; multidisciplinary; programs; recruit; skills; success; training opportunity

ABSTRACT: Chronic sequelae of long-term HIV infection and treatment including heart, lung, blood, and sleep (HLBS) co-morbidities are increasingly important causes of morbidity and mortality. Latent HIV and maladaptive inflammation also persist despite successful ART. Therefore, we propose a new training program in HIV-related research, the Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC), led by Drs. Alison Morris, Dr. John Mellors, and Solomon Ofori-Acquah. They have an outstanding training record for PhDs and MDs, and their research experience spans the spectrum from basic to translational to clinical with expertise in lung, blood, and vascular co-morbidities and HIV cure. HIV MeTrICC will be an interdisciplinary, intensive mentored research training and career development experience focused around two interrelated training tracks – HLBS Co-morbidities and HIV Cure with the following objectives: 1) To provide intensive mentoring in HIV-associated HLBS Co-morbidities and HIV Cure. Our team of established Mentors will offer unique multidisciplinary mentoring and career guidance to Scholars in the conduct of HIV research projects. Scholars will choose Mentors from the MeTrICC Co-morbidities and HIV Cure tracks. Tracks will be highly interactive. 2) To provide didactic training to foster progression to an independent career in HIV-related research. Formal training will encompass a broad spectrum of research methodologies, technologies, and analytical approaches to basic, clinical, and translational HIV research. Scholars with varying levels of prior research experience will be supported by Individual Development Plans geared to their needs. 3) To provide opportunities for training in Inner-city HIV and International HIV settings. Scholars will be able to choose from two different focus areas if relevant to their career plan. For the Inner-city HIV focus, we partner with the University of Maryland and the NIH to provide experience with the District of Columbia Partnership for AIDS Progress, the nation’s largest urban HIV cohort study. For our International HIV focus, we utilize several sites in Africa with ongoing basic, clinical, and translational research. 4) To provide access to large, multi-center HIV studies: Scholars will have access to large cohort studies including the Multicenter AIDS Cohort Study, the Women’s Interagency HIV Study, the Strategic Timing of Antiretroviral Therapy pulmonary substudy, the Pittsburgh HIV Lung Research Cohort, and the Pharmacokinetic and Clinical Observations in People over 50 sleep Substudy. 5) To support scholars in preparation of an independent research proposal: The program will ensure that Scholars rapidly develop grant-writing skills and submit competitive grant applications to help them secure HIV research funding. We will support five post-doctoral Scholars (MDs and PhDs) for a period of 2 to 3 years based on initial level of experience (i.e. post-docs vs junior faculty). The success of the MeTrICC program will be measured by concrete milestones such first author manuscripts, grant funding, and transition to faculty with the ultimate goal to recruit a new generation of researchers to HIV and HLBS complications.

摘要：长期HIV感染和治疗的慢性后遗症，包括心脏，肺，血液和睡眠 （HLB）合并症是发病率和死亡率的越来越重要的原因。潜伏的艾滋病毒和不良适应性 炎症也持续了成功的艺术。因此，我们提出了与HIV相关的新培训计划 研究，匹兹堡艾滋病毒指导了调查合并症和治疗的培训（HIV METRICC） 由Drs。艾莉森·莫里斯（Alison Morris），约翰·梅洛斯（John Mellors）博士和所罗门·阿卡（Solomon ofoi-Acquah）。他们有出色的训练记录 对于博士和MD，他们的研究经验跨越了从基本到翻译到临床的频谱 肺，血液和血管合并症和HIV治疗方面的专业知识。 HIV Metricc将是一个跨学科， 密集的指导研究培训和职业发展经验集中在两个相互关联的地方 培训轨道 - HLBS合并症和HIV与以下目标治愈：1）提供密集 与HIV相关的HLB合并症和HIV治疗中的指导。我们成熟的导师团队将提供 在艾滋病毒研究项目中，对学者的独特多学科指导和职业指导。 学者将从METRICC的合并症和HIV治疗轨道中选择导师。轨道将是高度的 交互的。 2）提供教学培训以促进与HIV相关的独立职业的发展 研究。正规培训将包括广泛的研究方法，技术和 基本，临床和翻译HIV研究的分析方法。先验水平不同的学者 研究经验将得到适合他们需求的个人发展计划的支持。 3）提供 在城市艾滋病毒和国际艾滋病毒环境中培训的机会。学者将能够选择 如果与他们的职业计划相关，则从两个不同的重点领域。对于内城艾滋病毒的重点，我们与 马里兰州大学和NIH分校提供哥伦比亚特区艾滋病合作伙伴关系的经验 进步，美国最大的城市艾滋病毒队列研究。对于我们的国际艾滋病毒重点，我们利用了几个网站 非洲具有持续的基本，临床和翻译研究。 4）提供获得大型多中心艾滋病毒的机会 研究：学者将可以访问大型队列研究，包括多中心艾滋病队列研究， 妇女的机构间艾滋病毒研究，抗逆转录病毒疗法的战略时机 匹兹堡艾滋病毒肺研究队列以及50岁以上的人的药代动力学和临床观察结果 睡眠典型。 5）支持学者准备独立研究建议：该计划 将确保学者迅速发展赠款技巧并提交竞争性赠款申请以帮助 他们获得艾滋病毒研究资金。我们将支持五个博士后学者（MDS和PHD） 根据初始经验水平（即，毕业后与初级教师）进行2至3年。 Metricc的成功 程序将通过具体里程碑来衡量，例如第一作者手稿，赠款资金以及过渡到 教师的最终目标是将新一代研究人员招募到HIV和HLBS并发症中。