Murine cardiac vector-flow imaging with high-frequency 2D row-column CMUT arrays
使用高频 2D 行列 CMUT 阵列进行小鼠心脏矢量流成像
基本信息
- 批准号:10444079
- 负责人:
- 金额:$ 76.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAnimal ModelAnimalsBlood flowCardiacCardiomyopathiesCardiovascular DiseasesCardiovascular PhysiologyCause of DeathCessation of lifeCharacteristicsComplexDataDeveloped CountriesDevelopmentDiagnosisDilatation - actionDiscriminationDiseaseDisease modelEarly DiagnosisElementsFailureFrequenciesGoalsHandHeartHeart failureHumanHypertrophyImageImaging DeviceImaging TechniquesItalyLeft ventricular structureLife ExpectancyMeasuresMechanicsMethodsModalityModelingMorbidity - disease rateMouse StrainsMusMyocardialMyocardial dysfunctionPathogenesisPathologicPatientsPatternPerformancePhenotypePhysiologyScanningSignal TransductionSpeedStressSystemTechniquesTestingTextThree-Dimensional ImagingTimeTractionTranslatingUltrasonographyaggressive therapyanimal imagingbaseburden of illnessconstrictiondesigndiagnostic toolheart imaginghemodynamicshigh riskimaging approachin vivoinstrumentationmanmillisecondmouse modelnoveloperationpre-clinicalpreclinical imagingpressureresponseserial imagingtargeted treatmenttemporal measurementtoolultrasoundvectorventricular hypertrophy
项目摘要
Project Summary/Abstract
Cardiovascular disease (CVD) accounts for one of every three deaths each year in the U.S. A substantial pro-
portion of patients with cardiovascular disease develop myocardial dysfunction. Imaging tools that permit early
detection of abnormal hemodynamics and/or mechanics provide an opportunity to initiate targeted therapeutics
and diminish the burden of disease. Mice are the most common model organism for translational CVD studies
of the mammalian heart. Ultrasound (US) is now extensively used in small animals to obtain cardiac functional
parameters. However, advanced US intracardiac vector-flow imaging techniques that are gaining traction for hu-
man CVD, such as cardiomyopathies, have yet to translate to preclinical use, thus, limiting the functional cardiac
parameters that can be obtained from mice. The ability to employ US vector-flow methods to simultaneously re-
solve complex, intracardiac blood flow patterns and cardiac mechanics at sub-millisec temporal resolution, prior
to overt structural and functional abnormalities, would add a new preclinical tool to study the interplay between
blood flow, cardiac mechanics and adaptation in CVD mouse models.
The goal of this project is to develop a novel, 30-MHz, 2D CMUT, row-column (RC) high-frequency-ultrasound
array and a plane-wave vector-flow imaging approach capable of sub-ms, full-frame image capture for intracardiac
imaging in mice. Unlike a standard linear array, the 2D CMUT array will allow dynamic, hands-free selection
of the optimal scan plane and the ability to acquire data in orthogonal image planes. In addition, the CMUT
array will allow us to collect data in adjacent planes to provide a 3D view of flow dynamics within the murine
heart. To validate our system and demonstrate the utility for small-animal imaging, we will study intracardiac left
ventricle (LV) blood flow patterns in two highly related mouse strains that nonetheless display divergent responses
(progressive hypertrophy vs. dilatation and failure) to abnormal pressure overload induced by the well-established
model of transverse aortic constriction (TAC). We hypothesize that our vector-flow system will be able to quantify
abnormal left ventricle flow patterns relative to sham control mice and that we will be able to detect flow disruption
prior to changes in traditional functional echo or strain measures. Importantly, we also hypothesize that distinct
flow pattern signatures can be identified early in the course of disease that will permit discrimination between
hearts that are destined to develop progressive hypertrophy vs. dilation. The ability to detect subtle phenotypic
changes in common mouse models of CVD that are a result of early-stage diseases or therapies may translate
to earlier and more aggressive treatment of patients at highest risk of pressure-overload induced heart failure.
项目概要/摘要
在美国,每年有三分之一的死亡病例是由心血管疾病 (CVD) 造成的。
部分心血管疾病患者会出现早期心肌功能障碍。
血流动力学和/或力学异常的检测为启动靶向治疗提供了机会
小鼠是转化性心血管疾病研究最常见的模型生物。
哺乳动物心脏的超声检查(美国)现在普遍用于小动物以获得心脏功能。
然而,美国先进的心内矢量流成像技术正在获得越来越多的关注。
人类心血管疾病(如心肌病)尚未转化为临床前使用,因此限制了功能性心脏功能
可以从小鼠获得的参数能够采用美国矢量流方法同时重新获得。
以亚毫秒时间分辨率解决复杂的心内血流模式和心脏力学问题
为了明显的结构和功能异常,将添加一种新的临床前工具来研究之间的相互作用
CVD 小鼠模型的血流、心脏力学和适应。
该项目的目标是开发一种新颖的 30 MHz、2D CMUT、行列 (RC) 高频超声
阵列和平面波矢量流成像方法,能够进行亚毫秒级、心内全帧图像捕获
与标准线性阵列不同,2D CMUT 阵列将允许动态、免提选择。
最佳扫描平面以及在正交图像平面中采集数据的能力。此外,CMUT。
阵列将允许我们收集相邻平面的数据,以提供小鼠体内流动动力学的 3D 视图
为了验证我们的系统并展示小动物成像的实用性,我们将研究左心内。
两种高度相关的小鼠品系的心室(LV)血流模式,但表现出不同的反应
(进行性肥大与扩张和衰竭)到由公认的压力引起的异常压力超负荷
我们发现我们的矢量流系统将能够量化横向主动脉缩窄(TAC)模型。
与假手术对照小鼠的异常左心室血流相对模式,我们将能够检测血流中断
重要的是,在传统功能回声或应变测量发生变化之前,我们也采取了这种独特的做法。
可以在疾病过程的早期识别流动模式特征,这将允许区分
注定会发展为进行性肥大与扩张的心脏 检测微妙表型的能力。
早期疾病或治疗导致的常见 CVD 小鼠模型的变化可能会转化
对压力过载诱发心力衰竭风险最高的患者进行早期和更积极的治疗。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Glenn I Fishman其他文献
Glenn I Fishman的其他文献
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{{ truncateString('Glenn I Fishman', 18)}}的其他基金
Transcriptional regulation in the ventricular conduction system
心室传导系统的转录调节
- 批准号:
10323660 - 财政年份:2019
- 资助金额:
$ 76.65万 - 项目类别:
Transcriptional regulation in the ventricular conduction system
心室传导系统的转录调节
- 批准号:
10063955 - 财政年份:2019
- 资助金额:
$ 76.65万 - 项目类别:
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